Biography

Dr. Jing Zheng

Department of Otolaryngology-Head and Neck Surgery, Feinberg School of Medicine

Northwestern University, USA

Associate Professor


Email: jzh215@northwestern.edu


Qualifications

1992 Ph.D., Physiology, Michigan State University, USA

1985 M.Sc, Virology, Wuhan University, China

1982 B.Sc., Biology, Wuhan University, China


Publications (Selected)

  1. Zheng, J., P. Lamoureux, V. Santiago, T. Dennerll, R. E. Buxbaum and S.R. Heideman, "Tensile regulation of axonal elongation and initiation." J. Neurosci., 11, 1117-1125, 1991
  2. Zheng, J., Buxbaum, R. E., and Heidemann, S. R., "Measurements of growth cone adhesion to culture surface by micromanipulation." J. Cell Biology. 127, 2049-2060, 1994
  3. Zheng, J., Shen, W., He, D. Z. Z., Long, K. B., Madison, L. D., Dallos, P., "Prestin is the motor protein of cochlear outer hair cells." Nature. 405, 149-155, 2000. With News and Views by M.C. Holley, ibid pp. 130-133 and News Focus by A. Cho in Science, 288, 1954-1955, 2000
  4. Zheng, J., Long, K. B., Shen, W., Madison, L. D., Dallos, P., "Prestin topology: location of protein epitopes in relation to the plasma membrane." NeuroReport, July 12, 1929-1935, 2001
  5. Zheng, J., He, D. Z. Z., Long, K. B., Dallos, P., Madison, L. D., "Identification of Differentially Expressed cDNA Clones from Gerbil Cochlear Outer Hair Cells." Audiol Neuro-Otol., 7, 227-288, 2002
  6. Zheng, J., Long, K. B., Matsuda, K., Madison L. D., Ryan, A., Dallos P., “Genomic characterization and expression of mouse prestin, the motor protein of outer hair cells.” Mammalian Genome, 14, 87-96, 2003 (Front cover)
  7. Liu X. Z., Ouyang, X. M., Xia X. J., Zheng, J., Pandya, A., Li, F., Du, L. L., Welch, K. O., Petit, C., Smith, R. J. H., Webb, B. J., Yan, D., Arnos, K. S., Corey, D., Dallos, P., Nance, W. E., Chen, Y. Z., "Prestin, a cochlear motor protein, is defective in non-syndromic hearing loss." Human Molecular Genetics, 12: 1155-1162, 2003 (Front cover)
  8. Zheng, J., Richter, C. P., Cheatham, M. A., "Prestin expression in the cochlea of the reeler mouse." Neuroscience letters, 347, 13-16, 2003
  9. Zheng, J., Du, G. G., Matsuda, K., Orem, A., Aguinaga, S., Deak, L., Navarrete, E., Madison, L. D., Dallos, P., "The C-terminus of prestin influences nonlinear capacitance and plasma membrane targeting." J Cell Sci. Jul 1; 118(Pt 13): 2987-96, 2005 (Front cover)
  10. Zheng, J., Du, G. G., Anderson, C. T., Keller, J. P., Orem, A., Dallos, P., Cheatham, M., "Analysis of the oligomeric structure of the motor protein prestin." J Biol Chem., 281(29): 19916-24, 2006
  11. Anderson, C. T., Zheng, J., "Isolation of outer hair cells from the cochlear sensory epithelium in whole-mount preparation using laser capture microdissection." J Neurosci Methods, 162: 229-236, 2007
  12. Dallos, P., Wu, X., Cheatham, M. A., Gao, J., Zheng, J., Anderson, C. T., Jia, S.,Wang, X., Cheng, H. Y. W., Sengupta, S.,  He, D. Z. Z., Zuo, J., “Prestin-based outer hair cell motility is necessary for mammalian cochlear amplification”. Neuron, May 8; 58 (3): 333-9, 2008
  13. Zheng, J., Anderson, C. T., Miller, K. K., Cheatham, M. A., Dallos, P., "Identifying components of the hair-cell interactome involved in cochlear amplification." BMC Genomics 10:127, 2009
  14. Sengupta, S., George, M., Miller, K. K., Naik, K., Chou, J., Cheatham, M. A., Dallos, P., Naramura, M., Band, H., Zheng, J., "EHD4 is an interacting partner for inner ear hair cell tip-link protein CDH23." J Biol Chem. 284(30): 20121-9, 2009
  15. Homma, K, Miller, K. K, Anderson, C. T, Sengupta, S., Du, G. G., Aguiñaga, S., Cheatham, M., Dallos, P., Zheng, J. "Interaction between CFTR and prestin (SLC26A5)."  Biochim Biophys Acta-Biomembranes. 1798(6): 1029-40, 2010. PMC2862844
  16. Sengupta, S., Miller, K. K., Homma, K., Edge, R., Cheatham, M. A., Dallos, P., Zheng, J. "Interaction between the motor protein prestin and the transporter protein VAPA."  Biochim Biophys Acta-Molecular Cell Research.  1803(7): 796-804, 2010.  PMC2878928
  17. Zheng, J., Miller, K. K., Yang, T., Hildebrand, M. S., Shearer, A. E., DeLuca, A. P., Scheetz, T. E., Drummond, J., Scherer, S., Legan, P. K., Goodyear, R., Richardson, G., Cheatham, M. A., Smith, R. J. H., Dallos, P., "Carcinoembryonic antigen-related cell adhesion molecule 16 interacts with α-tectorin and is mutated in autosomal dominant hearing loss (DFNA4)." PNAS.  108(10): 4218-23, 2011.  PMCID: PMC3054008
  18. Zheng, J., Furness, D., Duan, C., Miller, K. K., Edge, R. M., Chen, J.,  Homma, K., Hackney, C. M., Dallos, P., and Cheatham, M. A.,  "Marshalin, a microtubule minus-end binding protein, regulates cytoskeletal structure in the organ of Corti." Biology Open. 2(11) 1192-1202. 2013.  PMCID: PMC3828766
  19. Cheatham, M. A., Goodyear, R. J., Homma, K., Legan, P. K., Korchagina, J., Naskar, S., Siegel J. H., Dallos, P., Zheng, J., Richardson, G. P., "Loss of the Tectorial Membrane Protein, Ceacam16, Enhances Spontaneous, Stimulus-frequency and Transiently-evoked Otoacoustic Emissions."  J. Neurosci.  34: 10361-10378. 2014. PMCID:PMC4115139
  20. Cheatham M. A., Edge R.M., Homma K., Leserman E.L., Dallos P., Zheng J., "Prestin-Dependence of Outer Hair Cell Survival and Partial Rescue of Outer Hair Cell Loss in PrestinV499G/Y501H Knockin Mice."  PloS one. 10(12):e0145428, 2015. PMCID: PMC4684303
  21. Takahashi S., Homma K., Zhou Y., Nishimura S., Duan C., Chen J., Ahmad A., Cheatham M. A., Zheng J., "Susceptibility of outer hair cells to cholesterol chelator 2-hydroxypropyl-β-cyclodextrine is prestin-dependent." Scientific Reports. 2016 Feb 23;6:21973. PMCID: PMC4763217.
  22. Takahashi S., Cheatham M. A., Zheng J, Homma K., "The R130S mutation significantly affects the function of prestin, the outer hair cell motor protein." J Mol Med (Berl). 2016 Sep;94(9):1053-62. PMCID:PMC4992584
  23. Takahashi S., Mui V.J., Rosenberg, S., K., Homma K., Cheatham M. A., Zheng J., "Cadherin 23-C Regulates Microtubule Networks by Modifying CAMSAP3’s Function." Scientific Reports. 2016 Jun 28;6:28706. PMCID:PMC4923861
  24. Richter, CP., Tan, X., Young, H., Stock, S., Robinson, A.,  Byskosh, O., Zheng, J., Soriano, C., Xiao, X., Whitlon, D., "A comparison of classical histology to anatomy revealed by hard x-rays." Proc. SPIE 9967, Developments in X-Ray Tomography X, 99671I (October 3, 2016); doi:10.1117/12.2239146.
  25. Takahashi S., Sun W., Zhou Y., Homma K., Kachar B., Cheatham M. A., Zheng J., "Prestin Contributes to Membrane Compartmentalization and Is Required for Normal Innervation of Outer Hair Cells." Front Cell Neurosci. 2018; 12: 211. PMCID: PMC6062617
  26. Zhou Y, Takahashi S, Homma K, Duan C, Zheng J, Cheatham MA, Zheng J. "The susceptibility of cochlear outer hair cells to cyclodextrin is not related to their electromotile activity." Acta Neuropathol Commun. 2018 Sep 24;6(1):98. doi: 10.1186/s40478-018-0599-9. PubMed PMID: 30249300; PubMed Central PMCID: PMC6151916
  27. Takahashi S, Yamashita T, Homma K, Zhou Y, Zuo J, Zheng J, Cheatham MA. "Deletion of exons 17 and 18 in prestin's STAS domain results in loss of function."  Sci Rep. 2019 May 3;9(1):6874. doi: 10.1038/s41598-019-43343-y. PubMed PMID: 31053797; PubMed Central PMCID: PMC6499820
  28. Goodyear RJ, Cheatham MA, Naskar S, Zhou Y, Osgood RT, Zheng J, Richardson GP. "Accelerated Age-Related Degradation of the Tectorial Membrane in the Ceacam16βgal/βgal Null Mutant Mouse, a Model for Late-Onset Human Hereditary Deafness DFNB113." Front Mol Neurosci. 2019 Jun 12;12:147. doi: 10.3389/fnmol.2019.00147. PubMed PMID:31249509; PMCID: PMC6582249
  29. Robinson AM, Takahashi S, Brotslaw EJ, Ahmad A, Ferrer E, Procissi D, Richter CP, Cheatham MA, Mitchell BJ, Zheng J. "CAMSAP3 facilitates basal body polarity and the formation of the central pair of microtubules in motile cilia." Proc Natl Acad Sci U S A. 2020 Jun 16;117(24):13571-13579. doi: 10.1073/pnas.1907335117. Epub 2020 Jun 1. PubMed PMID: 32482850; PubMed Central PMCID: PMC7306751
  30. Zheng, J., S. Takahashi, Y. Zhou, and M.A. Cheatham. 2021. "Prestin and electromotility may serve multiple roles in cochlear outer hair cells." Hearing research: 2022 Sep 15:423:108428. doi: 10.1016/j.heares.2021.108428. Epub 2021 Dec 26
  31. O’Donnell, J. & Zheng, J. “Vestibular Hair Cells Require CAMSAP3, a Microtubule Minus-End Regulator, for Formation of Normal Kinocilia.” Frontiers in cellular neuroscience 16, doi:10.3389/fncel.2022.876805 (2022)
  32. Zheng J, Zhou Y, Fuentes RJ, Tan X. “Verification of Outer Hair Cell Motor Protein, Prestin, as a Serological Biomarker for Mouse Cochlear Damage.” Int J Mol Sci. 2024 Jul; 25(13): PMID: 39000390


Personal profile

https://www.feinberg.northwestern.edu/faculty-profiles/az/profile.html?xid=18813
https://orcid.org/0000-0003-2790-1143

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