Biography

Prof. Fang Yan

Department of Pediatrics, Division of Gastroenterology

Vanderbilt University Medical Center, USA


E-mail: fang.yan@vanderbilt.edu


Qualifications

1997 PhD, Cell Biology. Department of Anatomical Sciences and Neurobiology, University of Louisville, Louisville, KY

1991 M.D., Medicine, Tianjin Medical University, Eight-year Program, Tianjin, P. R. China


Publications (Selected)

  1. Day, N. L., Kaur, H., Townsend, S. D., Acra, S., & Yan, F. (2024). Sa1228 THE MECHANISM BY WHICH A HUMAN MILK OLIGOSACCHARIDE PROMOTES INTESTINAL FUNCTIONAL MATURATION. Gastroenterology, 166(5), S-390.
  2. Kaur, H., Washington, K., Peek, R. M., Acra, S., & Yan, F. (2024). Mo1891 EPIGENETIC REGULATION OF INTESTINAL STEM CELLS BY THE FUNCTIONAL PEPTIDE OF A PROBIOTIC-DERIVED PROTEIN FOR LONG-TERM PREVENTION OF COLITIS. Gastroenterology, 166(5), S-1162.
  3. Schalich, K. M., Buendia, M. A., Kaur, H., Choksi, Y. A., Washington, M. K., Codreanu, G. S., ... & Yan, F. (2024). A human milk oligosaccharide prevents intestinal inflammation in adulthood via modulating gut microbial metabolism. MBio, 15(4), e00298-24.
  4. Kaur, H., Ali, S. A., Short, S. P., Williams, C. S., Goettel, J. A., Washington, M. K., ... & Yan, F. (2023). Identification of a functional peptide of a probiotic bacterium-derived protein for the sustained effect on preventing colitis. Gut Microbes, 15(2), 2264456.
  5. Kasey, S., Buendia, M. A., Choksi, Y. A., Peek, R. M., Townsend, S. D., & Yan, F. (2023). 124 A HUMAN MILK OLIGOSACCHARIDE, 2'-FUCOSYLLACTOSE, PROTECTS INTESTINAL MUCOSAL INTEGRITY THROUGH REGULATION OF GUT MICROBIAL METABOLISM. Gastroenterology, 164(6), S-21.
  6. Schalich, K., Rajagopala, S., Das, S., O’Connell, R., & Yan, F. (2023). Intestinal epithelial cell-derived components regulate transcriptome of Lactobacillus rhamnosus GG. Frontiers in Microbiology, 13, 1051310.
  7. Zhao, G., Williams, J., Washington, M. K., Yang, Y., Long, J., Townsend, S. D., & Yan, F. (2022). 2’-Fucosyllactose ameliorates chemotherapy-induced intestinal mucositis by protecting intestinal epithelial cells against apoptosis. Cellular and Molecular Gastroenterology and Hepatology, 13(2), 441-457.
  8. Xun, Y., Yan, F., Zhu, H., Feng, L., Zhang, D., Xue, Y., ... & Wang, S. (2022). Oral administration of Lactobacillus paracasei N1115 on neonatal mice prevents the intestinal inflammation in adulthood. Letters in Applied Microbiology, 75(2), 330-337.
  9. Deng, Y., McDonald, O. G., Means, A. L., Peek Jr, R. M., Washington, M. K., Acra, S. A., ... & Yan, F. (2021). Exposure to p40 in early life prevents intestinal inflammation in adulthood through inducing a long-lasting epigenetic imprint on TGFβ. Cellular and molecular gastroenterology and hepatology, 11(5), 1327-1345.
  10. Yan, F. (2020). Mechanistic understanding of the symbiotic relationship between the gut microbiota and the host: An avenue toward therapeutic applications. Cellular and Molecular Gastroenterology and Hepatology, 10(4), 853-854.
  11. Yang, L., Higginbotham, J. N., Liu, L., Zhao, G., Acra, S. A., Peek Jr, R. M., ... & Yan, F. (2019). Production of a functional factor, p40, by Lactobacillus rhamnosus GG is promoted by intestinal epithelial cell-secreted extracellular vesicles. Infection and immunity, 87(7), 10-1128.
  12. Deng, Y., Liu, L. G., McDonald, O. G., Wilson, K. T., Peek, R. M., Li, H., ... & Yan, F. (2019). Tu1857–Neonatal Supplementation with a Lactobacillus Rhamnosus Gg (LGG)-Derived Protein, P40, Stimulates Persistent Induction of Regulatory T Cells in the Intestine Through Epigenetic Programming in Intestinal Epithelial Cells. Gastroenterology, 156(6), S-1149.
  13. Yang, L., Liu, L., Higginbotham, J. N., Zhao, G., Peek, R. M., Polk, D. B., ... & Yan, F. (2019). P129 intestinal epithelial cell-secreted extracellular vesicles promote the function of Lactobacillus rhamnosus GG against intestinal inflammation. Gastroenterology, 156(3), S88-S89.
  14. Shen, X., Liu, L., Peek, R. M., Acra, S. A., Moore, D. J., Wilson, K. T., ... & Yan, F. (2018). Supplementation of p40, a Lactobacillus rhamnosus GG-derived protein, in early life promotes epidermal growth factor receptor-dependent intestinal development and long-term health outcomes. Mucosal immunology, 11(5), 1316-1328.
  15. Yang, L. G., Liu, L. G., Higginbotham, J. N., Peek, R. M., Polk, D. B., Li, H., & Yan, F. (2018). Su1946-Intestinal Epithelial Cells Promote Growth and Function of Lactobacillus Rhamnosus GG (LGG) in Vitro and in Mice. Gastroenterology, 154(6), S-642.
  16. Cao, H., Liu, X., An, Y., Zhou, G., Liu, Y., Xu, M., ... & Wang, B. (2017). Dysbiosis contributes to chronic constipation development via regulation of serotonin transporter in the intestine. Scientific Reports, 7(1), 10322.
  17. Shen, X., Liu, L. G., Polk, D. B., Peek, R. M., Acra, S., He, F., & Yan, F. (2017). A Lactobacillus rhamnosus GG (LGG)-derived protein promotes intestinal development via activation of EGF receptor in intestinal epithelial cells. Gastroenterology, 152(5), S104.
  18. Cao, H., Xu, M., Dong, W., Deng, B., Wang, S., Zhang, Y., ... & Wang, B. (2017). Secondary bile acid‐induced dysbiosis promotes intestinal carcinogenesis. International journal of cancer, 140(11), 2545-2556.


Profile Details

https://wag.app.vanderbilt.edu/PublicPage/Faculty/Details/33885

https://www.researchgate.net/scientific-contributions/Fang-Yan-58802192

https://loop.frontiersin.org/people/969477/overview

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