Dr. Sonali Kurup
College of Pharmacy

Ferris State University, USA
Professor

Emial: SonaliKurup@ferris.edu

Qualifications

2011 Postdoctoral Training, University of Michigan, USA

2009 Ph.D., Medicinal Chemistry, Duquesne University, USA

2002 B.Sc., College of Pharmacy, Mumbai University, India

Publications (selected)

1. Kurup, S., Carpenter, G., Satawa, S., Amissah, F., Lisabeth, E., Gilletto, M., Ellsworth, E. (2024). "Novel analogs of 4-substituted pyrrolo[2,3-d]pyrimidines as dual-targeted mEGFR/AURKA inhibitors for lung cancer." Cancer Res. 84 (6-Suppl). p. 4474. Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR. https://doi.org/10.1158/1538-7445.AM2024-4474
2. Kurup, S., Gesisnski, D., Assaad, K., Reynolds, A. (2024). "Design, synthesis, and evaluation of dual EGFR/AURKB inhibitors as anticancer agents for non-small cell lung cancer." Bioorg Med Chem Lett. 100 p. 129612.
3. Sakharkar, P., Kurup, S., Deb, S., Assaad, K., Gesinski, D., Gayle, E. J. (2024). "Investigating the Efficacy of EGFR-TKIs and Anti-VEGFR Combination in Advanced Non-Small Cell Lung Cancer: A Meta-Analysis," Cancers. 16 (6). p. 1188. MDPI AG. https://doi.org/10.3390/cancers16061188
4. Rogers, B., Rohde, N., Mikitaroff, J., Matson, J., Satawa, S., Amissah, F., Kurup, S. (2023). "4-Amino-N-phenylbenzamides as dual-targeted mEGFR and AURK inhibitors and anticancer agents." Cancer Research. 83 (7_Suppl). p. 5339. Philadelphia (PA): In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR.
5. Gesinski, D., Kurup, S. (2023). "Design, synthesis and evaluation of dual-targeted mEGFR and AURK inhibitors as anticancer agents." Cancer Res. 83 In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023; 83(7_Suppl):Abstract 5337.
6. Sakharkar, P., Kurup, S. (2023). "Comparing Efficacy of Erlotinib and Bevacizumab Combination with Erlotinib Monotherapy in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC): A Systematic Review and Meta-Analysis," Diseases. 11 (4). p. 146. MDPI AG. https://doi.org/10.3390/diseases11040146
7. Cochran, C., Martin, K., Rafferty, D., Choi, J., Leontyev, A., Shetty, A., Kurup, S., Puthanveetil, P. (2023). "Untargeted Metabolomics Based Prediction of Therapeutic Potential for Apigenin and Chrysin." International journal of molecular sciences. 24 (4).
8. Kurup, S., Ding, Q., Amissah, F., Assaad, K., Chandrasekhara, S. (2020). "A meta-analysis comparing therapeutic outcomes for anti-EGFR monotherapy to targeted therapy combinations for non-small cell lung cancer." Journal of Clinical Oncology. 38 (suppl; abstr e21570). J Clin Oncol 38: 2020 (suppl; abstr e21570)
9. Vanangamudi, M., Kurup, S., Namasivayam, V. (2020). "Non-nucleoside reverse transcriptase inhibitors (NNRTIs): a brief overview of clinically approved drugs and combination regimens," Current Opinion in Pharmacology. 54 pp. 179-187. Elsevier BV. https://doi.org/10.1016/j.coph.2020.10.009
10. Namasivayam, V., Vanangamudi, M., Kramer, V. G., Kurup, S., Zhan, P., Liu, X., Kongsted, J., Byrareddy, S. N. (2019). "The Journey of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) from Lab to Clinic," Journal of Medicinal Chemistry. 62 (10). pp. 4851-4883. American Chemical Society (ACS) https://doi.org/10.1021/acs.jmedchem.8b00843
11. Kurup, Sonali & Sakharkar, Prashant. (2019). Three-Dimensional Visualization of Kinase Inhibitors as Therapeutically Relevant Examples To Reinforce Types of Enzyme Inhibitors. Journal of Chemical Education. 96. 10.1021/acs.jchemed.8b00403. 
12. Jungsuwadee, Paiboon & Sakharkar, Prashant & Kurup, Sonali. (2018). A Team‐based Assignment to Integrate Basic Science and Pharmacotherapeutic Principles for Anticancer Agents. The FASEB Journal. 31. 10.1096/fasebj.31.1_supplement.660.1. 
13. Samant, Amruta & Visal, Tanvi & Pancholi, Priya & Kansara, Dhvanir & Dichwalkar, Tanmay & Senones, Robert & Kurup, Sonali & Sehdev, Vikas. (2018). Design, synthesis, selection, and evaluation of a potent multi-kinase targeting N 4 -phenylsubstituted-7 H -pyrrolo[2,3- d ]pyrimidin-4-amine derivative with significant anticancer activity in P53 mutant and wild type models of upper gastrointestinal cancers. Cancer Research. 78. 2800-2800. 10.1158/1538-7445.AM2018-2800. 
14. Kurup, Sonali & Liskova, Pavlina & Jungsuwadee, Paiboon & Sakharkar, Prashant & Tambe, Soniya. (2018). A systematic review of randomized clinical trials for therapeutic outcomes of anti-EGFR agents used in combination with other targeted therapies. 78. 589-589. 10.1158/1538-7445.AM2018-589. 
15. Kurup, Sonali & McAllister, Bradley & Liskova, Pavlina & Mistry, Trusha & Fanizza, Anthony & Stanford, Dan & Slawska, Jolanta & Keller, Ulrich & Hoellein, Alexander. (2017). Design, synthesis and biological activity of N-phenylsubstituted-7H-pyrrolo[2,3-d]pyrimidin-4-amines as dual inhibitors of aurora kinase A and epidermal growth factor receptor kinase. Journal of Enzyme Inhibition and Medicinal Chemistry. 33. 74-84. 10.1080/14756366.2017.1376666. 
16. Visal, Tanvi & Patel, Shraddha & Pancholi, Priya & Bapat, Samhita & Samant, Amruta & Kansara, Dhvanir & Kurup, Sonali & Sehdev, Vikas. (2017). RS-41, a multi-targeted kinase inhibitor, induces cell cycle arrest and apoptosis in p53 mutant and wild type models of upper gastrointestinal cancers. Cancer Research. 77. 4180-4180. 10.1158/1538-7445.AM2017-4180. 
17. Kurup, Sonali & Jungsuwadee, Paiboon & Sakharkar, Prashant. (2017). A Team-based Assignment to Integrate Basic Science and Pharmacotherapeutic Principles for Anticancer Agents. American journal of pharmaceutical education. 81. 93. 10.5688/ajpe81593. 
18. Gangjee, Aleem & Kurup, Sonali & Smith, Charles. (2013). Synthesis of 5,7-disubstituted-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amines as microtubule inhibitors. Bioorganic & medicinal chemistry. 21. 10.1016/j.bmc.2012.12.029. 
19. Gangjee, Aleem & Kurup, Sonali & Ihnat, Michael & Thorpe, Jessica & Disch, Bryan. (2011). N-4-Aryl-6-substitutedphenylmethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diami nes as receptor tyrosine kinase inhibitors. Bioorganic & medicinal chemistry. 20. 910-4. 10.1016/j.bmc.2011.11.058. 
20. Gangjee, Aleem & Kurup, Sonali & Ihnat, Michael & Thorpe, Jessica & Shenoy, Satyendra. (2010). Synthesis and Biological Activity of N-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as Vascular Endothelial Growth Factor Receptor-2 Inhibitors and Antiangiogenic and Antitumor Agents. Bioorganic & medicinal chemistry. 18. 3575-87. 10.1016/j.bmc.2010.03.052. 

Profile Details

https://www.ferris.edu/pharmacy/profiles/pharmaceutical-science/sonali-kurup.html