Dr. Soumadwip Ghosh

Department of systems analysis, Illumina Inc, San Diego, La Jolla, USA

Scientist

Email: sghosh3@illumina.com

Qualifications

2017 Ph.D., Indian Institute of Technology Bombay, India.

2011 MSc., Indian Institute of Technology Dhanbad, India.

Publications (Selected)

1. Co-evolution and Structure Stabilization Modulate Olfactory Receptor Expression. Ghosh, S.; de March, C.; Branciamore, S.; Kaleem, S.; Matsunami, H.; Vaidehi, N Biophysical J. 2022, 121, 5, 830 – 840.
2. A Universal Allosteric Mechanism for G Protein Activation. Knight, M. K.; Ghosh, S.; Campbell, S. L.; Lefevre, T. J.; Olsen, R.; Smrcka, A. V.; Valentin, N. H.; Yin. G.; Vaidehi, N.; Dohlman, H. G. Mol. Cell 2021, 81(7), 1384 – 1396.
3. How do Branched Chain Detergents Stabilize GPCRs in Micelle? Lee, S.; Ghosh, S.; Jana, S.; Robertson, S.; Tate, C. G.; Vaidehi, N. Biochemistry 2020 , 59, 2125 – 2134.
4. Divergence from conserved residues underlies intracellular retention of mammalian odorant receptors. Ikegami, K.; de March, C.; Nagai, M.; Ghosh, S.; Do, M.; Sharma, R.; Bruguera, E.; Lu, Y.; Futukani, Y.; Vaidehi, N.; Yohda, M.; Matsunami, H. Proc. Natl. Acad. Sci. 2020, 117, 2957.
5. Machine Learning for Prioritization of Thermostabilizing Mutations for G-protein Coupled Receptors. Muk, S.; Ghosh, S.; Achutan, S.; Chen, X.; Yao, X.; Sandhu, M.; Griffor, M. C.; Fennell, K. F.; Che, Y.; Shanmugasundaram, V.; Qiu, X.; Tate, C. G.; Vaidehi, N. Biophysical J. 2019, 117 (equal contribution first author).
6. Prediction of Conformation Specific Thermostabilizing Mutations for Class AG Protein-Coupled Receptors. Jana, S.; Ghosh, S.; Muk, S.; Levy, B.; Vaidehi, N. J. Chem. Inf. Model. 2019, 59, 3747 – 3754 (equal contribution first author).
7. Variable G protein determinants of GPCR coupling selectivity. Okashah, N.; Wan, Q.; Ghosh, S.; Sandhu, M.; Vaidehi, N.; Lambert, N. A. Proc. Natl. Acad. Sci. 2019, 116, 12049 – 12054.
8. Engineering Salt Bridge Networks between Transmembrane Helices Confers Thermostability in G-Protein-Coupled Receptors. Ghosh, S.; Bierig, T.; Lee, S.; Jana, S.; Lohle, A.; Schnapp, G.; Tautermann, C.; Vaidehi, N. J. Chem. Theor. Comput. 2018, 14, 6574 – 6585.
9. Azadirachtin inhibits amyloid formation, disaggregates pre-formed fibrils and protects pancreatic β-cells from human islet amyloid polypeptide/amylin-induced cytotoxicity. Dubey, R.; Patil, K.; Dantu, S. C.; Sardesai, D. M.; Bhatia, P.; Malik, N.; Acharya, J. D.; Sarkar, S.; Ghosh, S.; Chakrabarti, R.; Sharma, S.; Kumar, A. Biochemical J. 2019, 476, 889 – 907 .
10. Salt Induced Structural Collapse, Swelling, and Signature of Aggregation of Two ssDNA Strands: Insights from Molecular Dynamics Simulation. Sarkar, S.; Maity, A.; Phukon, A. S.; Ghosh, S.; Chakrabarti, R. J. Phys. Chem. B, 2018, 123, 47 – 56.
11. Ammonium based stabilizers effectively counteract urea-induced denaturation in a small protein: insights from molecular dynamics simulations. Sarkar, S.; Ghosh, S.; Chakrabarti, R. RSC Adv. 2018, 7, 52888 – 52906.
12. Can Ammonium Based Room Temperature Ionic Liquid Counteract the Urea- Induced Denaturation of a Small Peptide? Ghosh, S.; Dey, S.; Patel, M.; Chakrabarti, R. Phys. Chem. Chem. Phys. 2017, 19, 7772-7787.
13. Molecular Dynamics Simulations Elucidates the Preferential Binding Affinity of Sodium and Tetramethylammonium Ions for Tetrameric Nafion Unit under Aqueous Conditions- Ghosh, S and Chakrabarti, R. RSC Adv. 2016, 6, 97961-97968.
14. Unzipping of Double Stranded Ribonucleic Acids by Graphene and Single-Walled Carbon Nanotube: Helix Geometry versus Surface Curvature- Ghosh, S and Chakrabarti. R. J. Phys. Chem. C 2016, 120, 22681 – 22693.
15. Spontaneous Unzipping of Xylonucleic Acid Assisted by a Single-Walled Carbon Nanotube: A Computational Study- Ghosh, S and Chakrabarti. R.; J. Phys. Chem. B 2016, 120, 3642–3652.
16. Probing the Salt Concentration Dependent Nucleobase Distributions in a Single- Stranded DNA – Single Walled Carbon Nanotube Hybrid- Ghosh, S.; Patel, S.; Chakrabarti. R. J. Phys. Chem. B 2016, 120, 455 – 466.
17. Thermodynamics of Site Specific Small Molecular Ion Interaction with DNA Duplex: A Molecular Dynamics Study- Ghosh, S.; Dixit, M. K.; Chakrabarti. R. Molecular Simulation 2016, 42, 715 – 724.
18. Ion Assisted Structural Collapse of a Single Stranded DNA: A Molecular Dynamics Approach- Ghosh, S.; Dixit, H.; Chakrabarti. R. Chem. Phys. 2015, 459, 137 – 147.

Profile Details

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