Prof. Brumeanu Teodor-Doru

Uniformed Services University of Health Sciences, USA

Email: teodor-doru.brumeanu@usuhs.edu

Qualifications

1980-1981 Assistant Professor, Department of Microbiology, Faculty of General Medicine, Bucharest, Romania

1986-1990 Postdoctoral Fellow, Department of Immunology, University of Manitoba, Winnipeg, Canada

1991-1995 Postdoctoral Fellow, Department of Microbiology, Mount Sinai School of Medicine, New York, USA

1995-2004 Assistant Professor, Department of Microbiology, Mount Sinai School of Medicine, New York, USA

2004-2008 Associate Professor, Department of Molecular and Cellular Biology, Uniformed Services University of Health Sciences, Bethesda, USA

2008-Present  Professor, Department of Molecular and Cellular Biology, Uniformed Services University of Health Sciences, Bethesda, USA.

Publications (Selected)

1. Mendoza M, Gunasekera D, Pratt KP, Qiu Q, Casares S, and Brumeanu T-D. The humanized DRAGA mouse (HLA-A2. HLA-DR4. RAG1 KO. IL-2R g c KO. NOD) establishes inducible and transmissible models for influenza type A infections. Hum. Vaccin. Immunother. 2020, 1-16. doi: 10.1080/21645515.2020.1713605.
2. Majji S, Wijayalath W, Shashikumar S, Pow Sang L, Villasante E, Brumeanu T-D, Casares S. Differential effect of HLA class-I versus class-II transgenes on human T and B cell reconstitution and function in NRG mice. Sci. Rep. 2016, 6:28093. doi: 10.1038/srep2809.
3. Surls J, Nazarov-Stoica C, Kehl M, Casares S, Brumeanu T-D. Increased membrane cholesterol in lymphocytes diverts T-cells toward an inflammatory response. PlosONE 7: e38733 (2012).
4. Danner R, Chaudhari SN, Rosenberger J, Surls J, Richie TL, Brumeanu T-D, and Casares S. Expression of HLA class II molecules in humanized NOD. Rag1 KO. IL2Rg KO HLA-DR4 mice is critical for the development and function of human T and B cells. Plos ONE 6:e19826, 2011.
5. Duncan B , Nazarov–Stoica C, Surls J, Kehl M, Bona CA, Casares S, Brumeanu T-D. Double negative, splenic (CD3+4-8-) TCRaß cells from young NOD mice provide long-term protection against type 1 diabetes. PlosONE e11427 (2010).
6. Nazarov-Stoica C, Surls J, Bona CA, Casares S, Teodor-D. Brumeanu. CD28 Signaling in T Regulatory Precursors Requires p56lck and Rafts Integrity to Stabilize the Foxp3 Message. J Immunol 182: 102-110 (2009).
7. Lin M, Zhang N, Teijaro JR, Stoica C, Bona CA, McEvoy R, Farber D, Casares S, Brumeanu T-D. A Peptide-MHC II Chimera Favors Survival of Pancreatic b-islets Grafted in Type 1 Diabetic Mice. Transplantation 85:1717-1725 (2008).
8. Preda A, Stan A, Casares S, Bona CA, Brumeanu T-D. Efficacy of clonal deletion vs anergy of self-reactive CD4 T-cells for the prevention and reversal of type 1 diabetes. J Autoimmunity 25: 21-32 (2005).
9. Thomas S, Preda-Pais A., Kumar R. S., Casares S., and Brumeanu T-D. A model for antigen-specific T cell anergy: displacement of CD4-p56lck signalosome from the lipid rafts by a soluble, dimeric peptide-MHC II chimera. J Immunol 170: 5981-5992 (2003).
10. Casares S, Hurtad A, von Boehmer H, Sarukhan A, McEvoy R, and Brumeanu T-D. Downregulation of diabetogenic T-cells by a soluble MHC II-peptide chimera. Nature Immunology 3 (4): 383-391 (2002).
11. Casares S., Bona, C., and Brumeanu T-D. Antigen-specific down-regulation of T-cells by doxorubicin delivered by MHC II-peptide chimeras. Nature Biotechnology 19: 142-147 (2001).
12. Casares, S., C. S. Zong, D. L. Radu, A. Miller, C. A. Bona, and T-D. Brumeanu. Antigen-specific signaling by a soluble, dimeric peptide/MHC Class II/Fc chimera leading to Th2 differentiation. J.Exp.Med 190: 543-553 (1999).
13. Brumeanu T-D, Casares S, Harris PE, Dehazya P, Wolf I, Bona CA. Immunopotency of a viral peptide assembled on the carbohydrate moieties of immunoglobulins, Nature/Biotechnology 14:722-725 (1996).
14. Brumeanu T-D, Swiggard WJ, Steinman RM, Zaghouani H, Bona CA. Efficient loading of identical peptide onto class II molecules by antigenized immunoglobulin and influenza virus. J Exp Med 178: 1795-1799 (1993).

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