Department of Medicinal Chemistry, Faculty of Pharmacy

Assiut University, Egypt

Professor

Email: fadl@aun.edu.eg

Qualifications

1994 Ph.D., Assiut University-Egypt and Josai University, Pharmaceutical Sciences

1989 M.Sc., Assiut University, Pharmaceutical Sciences

1984 B.Sc., Assiut University, Pharmaceutical Sciences

Publications (selected)

1. A highly sensitive automated flow immunosensor based on kinetic exclusion analysis for determination of the cancer marker 8-hydroxy-2`-deoxyguanosine in urine. Ibrahim Ali Darwish, Tanveer A Wani, Nasr Khalil, Tarek Aboul-Fadl, Adnan Kadi and Abdul-Rahman Al-Majed. Anal. Methods (2013), (In Press) DOI: 10.1039/C3AY26292H
2. Design, Synthesis and Pharmacophoric Model Building of Novel Substituted Nicotinic Acid Hydrazones with Potential Antiproliferative Activity. Hatem A. Abdel-Aziz, Tarek Aboul-Fadl, Abdul-Rahman M. Al-Obaid, Mohamed Ghazzali, Abdullah Al-Dhfyan and Alessandro Contini. Archives of Pharmacal Research, 35, 1543-1552 (2012).
3. Schiff bases of indoline-2, 3-dione (isatin) with potential antiproliferative activity, Tarek Aboul-Fadl, Awwad A. Radwan, Mohamed Attia, Abdullah Al-Dhfyan, Hatem A. Abdel-Aziz. Chemistry Central Journal, 6, 49 (2012). doi:10.1186/1752-153X-6-49.
4. Novel Schiff bases of indoline-2,3-dione and nalidixic acid hydrazide: synthesis, in vitro antimycobacterial and in silico mycobacterium tuberculosis (mtb) DNA gyrase inhibitory activity. Tarek Aboul-Fadl, Awwad A. Radwan, Hatem A. Abdel-Aziz, Mohd. Baseeruddin, Mohamad I. Attia and Adnan Kadi. Digest Journal of Nanomaterials and Biostructures, 7, 329-338 (2012).
5. 3,5-Disubstituted Thiadiazine-2-thiones: A New Cell-Cycle Inhibitors. Awwad A. Radwan, Abdullah Al-Dhfyan, Mohammed K. Abdel-Hamid, Abdullah A. Al-Badr and Tarek Aboul-Fadl. Archives of Pharmacal Research, 35, 35-49 (2012).
6. Amantadine Amides Prodrugs as Hepatic Delivery Systems to Enhance its Activity against HCV. Tarek Aboul-Fadl, Mahmoud M. Sheha, Adel S. El-Azab, Hatem A. Abdel-Aziz. Digest Journal of Nanomaterials and Biostructures, 6, 1675-1683 (2011).
7. Schiff Bases of Indoline-2,3-Dione: Potential Novel Inhibitors of Mycobacterium Tuberculosis (Mtb) DNA Gyrase. Tarek Aboul-Fadl, Hatem A. Abdel-Aziz, Mohammed K. Abdel-Hamid, Tilal Elsaman, Jane Thanassi and Michael J. Pucci. molecules, 16, 7864-7879 (2011).
8. (Z)-Ethyl2-cyano-2-(2-(5,6-dimethyl-4-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl)hydrazono)acetate.Hoong-Kun Fun, Madhukar Hemamalini, Hatem A. Abdel-Aziz and Tarek Aboul-Fadl. Acta Crystallographica Section E, 67, o2145–o2146 (2011).
9. Microwave-Assisted Solution-Phase Synthesis and DART-Mass Spectrometric Monitoring of Combinatorial Library of Indolin-2, 3-Dione Schiff Bases with Potential Antimycobacterial Activity. Tarek Aboul-Fadl, Hatem A. Abdel-Aziz, Adnan Kadi, Pervez Ahmad, Tilal Elsaman, Mohamed W. Attwa and Ibrahim A. Darwish. molecules, 16, 5194-5206 (2011).
10. Microwave-assisted, One-step Synthesis of Fenamic Acid Hydrazides from Their Acids. Tarek Aboul-Fadl, Hatem A. Abdel-aziz, Adnan Kadi, Ahmed Bari, Pervez Ahmad, Tilal Al-samani, Seik Weng Ng. molecules,16, 3544-3551 (2011).
11. Cell Screening Assay for Identifying Inhibitors of Eosinophil Proliferation. Jessica J. Kempe-Dustin, Tarek Aboul-Fadl, Clarissa Christensen, Robert Palais, Krishna Parsawar, Gerald J. Gleich, and Lori A. Wagner. Drug Development Research, 72 (4), 353-360 (2011).
12. (Z)-3Hydrazinylidene-1-phenylindolin-2-one. Hatem A. Abdel-Aziz, AhmedBari, T. Aboul-Fadl and Seik Weng Ng. Acta Crystallographica Section E, 66 (Pt 11): o3014 (2010)
13. Effects of Isatin-Isoniazid Derivatives on Drug Metabolizing and Chemoprotective Enzymes in Mice. Wael M. El-Sayed, Tarek Aboul-Fadl, and Michael R. Franklin. Drug Development Research, 71, 313-322 (2010).
14. Schiff Bases of Indoline-2, 3-dione (Isatin) Derivatives and Nalidixic Acid Carbohydrazide, Synthesis, Antitubercular Activity and Pharmacophoric Model Building. Tarek Aboul-Fadl, Fayzah A. S. Bin-Jubair and Omima Aboul-Wafa. Eur. J. Med. Chem. 45, 4578-4586 (2010).
15. Cell Cycle Disruption and Apoptotic Activity of 3-Aminothiazolo [3,2-a]benzimidazole-2-carbonitrile and its homologues. Abdelwareth A. O. Sarhan, Abdullah Al-Dhfyan, Maha A. Al-Mozaini, Chaker N. Adra, and Tarek Aboul-Fadl. Eur. J. Med. Chem., 45, 2689-2694 (2010).
16. Anti-Tubercular Activity of Isatin Derivatives. Tarek Aboul-Fadl and Fayzah A. S. Bin-Jubair. Int. J. Res. Pharm. Sci. 1(2), 113-126 (2010).
17. New Sensitive HPLC Method for Evaluation of the Pharmacokinetics of New Amantadine Prodrugs as Hepatic Delivery Systems to Enhance its Activity against HCV. Ibrahim A. Darwish, Tarek Aboul-Fadl, Nasr Y. Khalil, Ashraf M. Mahmoud, Abdul-Rahman M. Al-Obaid. Int. J. Res. Pharm. Sci. 1(2), 151-157 (2010).
18. Pharmacophoric Model Building for Antitubercular Activity of the Individual Schiff Bases of Small Combinatorial Library. Wesam S. Abdel-Aal, Hoda Y.Hassan, Tarek Aboul-Fadl and Adel F. Youssef, Eur. J. Med. Chem., 45, 1098-1106 (2010).
19. Solution-Phase Synthesis of Small Schiff Bases Combinatorial Library with Potential Antitubercular Activity. Wesam S. Abdel-Aal, Hoda Y.Hassan, Tarek Aboul-Fadl and Adel F. Youssef, Der Pharma Chemica, 1, 1-13 (2009).
20. Selective Spectrophotometric and Fluorometric Method for the Determination of Amantadine Hydrochloride in Capsules and Plasma via Derivatization with Sodium 1, 2- Naphthoquinone-4-Sulphonate. Ashraf M. Mahmoud, Nasr Y. Khalil, Ibrahim A. Darwish, Tarek Aboul-Fadl, Intl. J. Anal. Chem, 1-9 (2009).
21. A highly sensitive enzyme immunoassay for evaluation of 2_-deoxycytidine plasma level as a prognostic marker for breast cancer chemotherapy. Ibrahim A. Darwish, Ashraf M. Mahmoud, Tarek Aboul-Fadl, Abdul-Rahman A. Al-Majed, Nasr Y. Khalil. Analytica Chimica Acta, 632, 266–271 (2009).
22. Synthesis of a Peptide Nucleic Acid with a Novel 1-Methyl-6-mercaptopurine Base. Tarek Aboul-Fadl, Gopalan Rajeev Kallanthottathil and Arthur D. Broom. J. Heterocyclic Chem., 45, 445-451 (2008).
23. Pre- and post-initiation chemoprevention activity of 2-alkyl/aryl selenazolidine-4(R)-carboxylic acids against tobacco-derived nitrosamine (NNK)-induced lung tumors in the A/J mouse. M. R. Franklin, P. J. Moos, W. M. El-Sayed, T. Aboul-Fadl, J.C. Roberts. Chem-Biol Interactions, 168, 211–220 (2007).
24. Murine Hepatoma (Hepa1c1c7) Cells: A Responsive In Vitro System for Chemoprotective Enzyme Induction by Organoselenium Compounds. Wael M. El-Sayed, Tarek Aboul-Fadl, Jeanette C. Roberts, John G. Lamb and Michael R. Franklin. Toxicology in Vitro, 21, 157-164 (2007).
25. Antisense Oligonucleotide Technologies in Drug Discovery. Tarek Aboul-Fadl, Expert Opin. Drug Discov. 1, 285-288 (2006).

Profile Details

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