Department of Medicinal Chemistry, Faculty of Pharmacy

Assiut University, Egypt

Professor

Email: fadl@aun.edu.eg

Qualifications

1994 Ph.D., Assiut University-Egypt and Josai University, Pharmaceutical Sciences

1989 M.Sc., Assiut University, Pharmaceutical Sciences

1984 B.Sc., Assiut University, Pharmaceutical Sciences

Publications (Selected)

1. Shin, S. H., Ye, M. K., Chae, M. H., Geum, S. Y., Aboraia, A. S., Abdel-Aal, A. B. M., ... & Aboul-Fadl, T. (2024). Anti-Allergic and Anti-Inflammatory Effects of Lidocaine-Derived Organic Compounds in a House Dust Mite-Induced Allergic Rhinitis Mouse Model. Biomedicines, 12(9), 1965.
2. Qayed, W. S., Hassan, M. A., Abouwarda, A. M., Ibrahim, Y. M., & Aboul-Fadl, T. (2024). Computational Design of Azine-Linked Hybrids of 2-Indolinone-Thiazolodine Scaffold as Novel and Promising Quorum Sensing Inhibitors. Polycyclic Aromatic Compounds, 44(1), 1-24.
3. Shin, S. H., Ye, M. K., Chae, M. H., Geum, S. Y., Aboraia, A. S., Abdel-Aal, A. B. M., ... & Aboul-Fadl, T. (2023). Effects of lidocaine-derived organic compounds on eosinophil activation and survival. Molecules, 28(15), 5696.
4. Qayed, W. S., Hassan, M. A., El-Sayed, W. M., Silva, J. R. A., & Aboul-Fadl, T. (2022). Novel azine linked hybrids of 2-indolinone and thiazolodinone scaffolds as CDK2 inhibitors with potential anticancer activity: in silico design, synthesis, biological, molecular dynamics and binding free energy studies. Bioorganic Chemistry, 126, 105884.
5. Abd El-wahab, H. A., Mansour, H. S., Ali, A. M., El-Awady, R., & Aboul-Fadl, T. (2022). New cell cycle checkpoint pathways regulators with 2-Oxo-indoline scaffold as potential anticancer agents: Design, synthesis, biological activities and in silico studies. Bioorganic Chemistry, 120, 105622.
6. Abdel El‐wahab, H. A., Hamdy, A. K., Schulzke, C., Aboul‐Fadl, T., & Qayed, W. S. (2021). Crystal structure and quantum chemical calculations of (E) 1‐benzyl‐3‐((4‐methoxyphenyl) imino)‐5‐methylindolin‐2‐one. Journal of Heterocyclic Chemistry, 58(8), 1601-1609.
7. Mansour, H. S., Abd El-wahab, H. A., Ali, A. M., & Aboul-Fadl, T. (2021). Inversion kinetics of some E/Z 3-(benzylidene)-2-oxo-indoline derivatives and their in silico CDK2 docking studies. RSC advances, 11(14), 7839-7850.
8. Yousef, M. A., Ali, A. M., El-Sayed, W. M., Qayed, W. S., Farag, H. H., & Aboul-Fadl, T. (2020). Design and synthesis of novel isatin-based derivatives targeting cell cycle checkpoint pathways as potential anticancer agents. Bioorganic chemistry, 105, 104366.
9. Aboul-Fadl, T., Al-Hamad, S. S., & Fouad, E. A. (2018). Pharmacokinetic studies of naproxen amides of some amino acid esters with promising colorectal cancer chemopreventive activity. Bioorganic Chemistry, 76, 370-379.
10. Elsaman, T., Aldeeb, O. A., Aboul-Fadl, T., & Hamedelneil, E. I. (2017). Synthesis, characterization and pharmacological evaluation of certain enzymatically cleavable NSAIDs amide prodrugs. Bioorganic Chemistry, 70, 144-152.
11. Abdu-Allah, H. H., Youssif, B. G., Abdelrahman, M. H., Abdel-Hamid, M. K., Reshma, R. S., Yogeeswari, P., ... & Sriram, D. (2017). Synthesis and anti-mycobacterial activity of 4-(4-phenyl-1 H-1, 2, 3-triazol-1-yl) salicylhydrazones: revitalizing an old drug. Archives of pharmacal research, 40, 168-179.
12. Aboul-Fadl, T., Abdel-Hamid, M. K., & Youssef, A. F. (2015). Schiff bases of indoline-2, 3-dione (isatin) derivatives as efficient agents against resistant strains of Mycobacterium tuberculosis. Der Pharma Chem, 7, 217-225.
13. Osman, A. M. G., Abourashed, E. A., Slade, D., Ahmed, S. A., Gul, W., Khan, S. I., ... & ElSohly, M. A. (2015). Synthesis and in vitro evaluation of ferutinol aryl esters for estrogenic activity and affinity toward cannabinoid receptors. Medicinal Chemistry Research, 24, 2670-2678.
14. Aboul-Fadl, T., Al-Hamad, S. S., Lee, K., Li, N., Gary, B. D., Keeton, A. B., ... & Abdel-Hamid, M. K. (2014). Novel non-cyclooxygenase inhibitory derivatives of naproxen for colorectal cancer chemoprevention. Medicinal Chemistry Research, 23, 4177-4188.

Profile Details

WoS ResearcherID: DWG-1384-2022

https://orcid.org/0000-0002-1963-4332

https://aun.edu.eg/pharmacy/tarek-aboul-fadl-mohammad-hassan

https://scholar.google.com.hk/citations?hl=zh-CN&user=e2ALmfAAAAAJ

https://www.researchgate.net/profile/Tarek-Aboul-Fadl3