Dr. Robin D. Couch

George Mason University, USA

Associate Professor



2000 Ph.D., University of Calgary, Biochemistry

1994 B.S., University of Calgary, Biochemistry

Publications (Selected)

  1. McKenney, E., Sargent, M., Khan, H., Couch, R.D., Uh, E., San Jose, G., Dowd, C., and van Hoek, M., Lipophilic Prodrugs of FR900098 are Antimicrobial Against Francisella in vivo and in vitro and Show GlpT Independent Efficacy. PLoS ONE 2012 [accepted].
  2. Li RW, Wu S, Li W, Navarro K, Couch R.D., Hill D, and Urban JF Jr., Alterations in the porcine colon microbiota induced by the gastrointestinal nematode Trichuris suis. Infect Immun. 2012 Apr 9. [Epub ahead of print]
  3. Couch, R.D. and Mott, B., Personalized medicine: changing the paradigm of drug development. Methods Mol Biol. 2012 823: 367-78.
  4. Tsang, A., Seidle, H., Jawaid, S., Zhou, W., Smith, C., and Couch, R.D., Francisella tularensis 2-C-Methyl-D-Erythritol 4-Phosphate Cytidylyltransferase: Kinetic Characterization and Phosphoregulation. PLoS ONE 2011, 6 (6): e20884. doi: 10.1371/journal.pone.0020884. PMC3111433.
  5. Dixon, E., Clubb, C., Pittman, S., Ammann, L., Rasheed, Z., Kazmi, N., Keshavarzian, A., Gillevet, P., Rangwala, H., and Couch, R.D., Solid-phase microextraction and the human fecal VOC metabolome. PLoS ONE 2011, 6 (4): e18471. doi: 10.1371/journal.pone.0018471.
  6. Jawaid, S., Gertz, M., Corsino, C., Cheung, J., Seidle, H., and Couch, R.D., Engineering a Statin-Resistant Isoform of the Human Hydroxymethylglutaryl-Coenzyme A Reductase (HMGCR). Ind. J. Biochem Biophys. 2010 47 (6): 331-339.
  7. Dixon, E., Schweibenz, T., Hight, A., Kang, B., Dailey, A., Kim, S., Chen, M, Kim, Y., Neale, S., Groth, A., Ike, T., Khan, S., Schweibenz, B., Lieu, D., Stone, D., Orellana, T., and Couch, R.D., Bacteria-Induced Static Batch Fungal Fermentation of the Diterpenoid Cyathin A3, a Small Molecule Inducer of Nerve Growth Factor. J. Ind. Microbiol Biotechnol. 2010, DOI: 10.1007/s10295-010-0805-7 Online First™.
  8. Jawaid, S., Seidle, H., Zhou, W., Abdirahman, H., Abadeer, M., Hix, J.H., van Hoek, M.L., Couch, R.D., Kinetic Characterization and Phosphoregulation of the Francisella tularensis 1-Deoxy-D-Xylulose 5- Phosphate Reductoisomerase (MEP Synthase). PLoS ONE 2009, 4(12):e8288.
  9. Couch, R.D., Ganem, N.J., Zhou, M., Popov, V., Veenstra, T.D., Sporn, M.B., and Anderson, A.C., CDDO disrupts microtubule polymerization: A possible mechanism of its apoptotic activity. Mol Pharmacol 2006, 69 (4): 1158-1165.
  10. Seidle, H.F., Couch, R.D., and Parry, R.J., Characterization of a nonspecific phosphopantetheinyl transferase from Pseudomonas syringae pv syringae FF5. Arch Biochem Biophys 2006, 446 (2): 167-74.
  11. Couch, R.D., Browning, R.G., Honda, T., Gribble, G.W., Wright, D.L., Sporn, M.B., and Anderson, A.C., Studies on the reactivity of CDDO, a promising new chemopreventive and chemotherapeutic agent: implications for a molecular mechanism of action. Bioorg Med Chem Lett 2005, 15 (9): 2215-2219.
  12. Honda, T., Janosik, T., Honda, Y., Han, J., Liby, K.T., Williams, C.R., Couch, R.D., Anderson, A.C., Sporn, M.B., and Gribble, G.W., Design, synthesis, and biological evaluation of biotin-conjugates of 2-cyano-3,12-dioxooleana-1,9 (11)-diene-28-oic acid for the isolation of the protein targets. J Med Chem 2004, 47 (20): 4923-4932.
  13. Couch, R.D. and Gaucher, G.M., Rational elimination of Aspergillus terreus sulochrin production. J Biotechnol 2004, 108 (2): 171-178.
  14. Seidle, H.F., Rangaswamy, V., Couch, R.D., Bender, C.L., and Parry, R.J., Characterization of Cfa1, a monofunctional acyl carrier protein involved in the biosynthesis of the phytotoxin coronatine. J Bacteriol 2004, 186 (8): 2499-2503.
  15. Couch, R.D., O'Connor, S.E., Seidle, H.F., Walsh, C.T., and Parry, R.J., Characterization of CmaA, an adenylation-thiolation didomain enzyme involved in the biosynthesis of coronatine. J Bacteriol 2004, 186 (1): 35-42.
  16. Couch, R.D., Seidle, H.F., and Parry, R.J., Construction of expression vectors to produce affinity-tagged proteins in Pseudomonas. Biotechniques 2002, 32 (6): 1230-1236.

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