Prof. Azzam A. Maghazachi

Department of Physiology

University of Oslo, Norway

Email: azzam.maghazachi@medisin.uio.no

Qualifications

1984 Ph.D., Department of Immunology, University of Manitoba, Canada

1976 M.S., Department of Microbiology, New York University, New York, USA

Publications (Selected)

1. Høglund R, Harbo HF, Holmøy T, Maghazachi AA. A one year follow-up study of natural killer and dendritic cells activities in multiple sclerosis patients receiving glatiramer acetate. Submitted.
2. Maghazachi AA. Role of natural killer cells in multiple sclerosis. ISRN Immunology, In press, 2012.
3. Rolin J, Al-Jaderi Z, Maghazachi AA. Oxidized lipids and lysophosphatidylcholine induce the chemotaxis and intracellular calcium influx in natural killer cells. Immunobiology, In press, 2012.
4. Pandya A, Høglund RA, Holmøy T, Harbo HF, Norgauer J, Maghazachi AA. Identification of human NK17/NK1 cells. PLoS ONE 6(10): e26780, 2011.
5. Rolin J, Maghazachi AA. Effects of Lysophospholipids on Tumor Microenvironment. Cancer Microenvironment 4: 393-403, 2011.
6. Høglund R, Hestvik ALK, Holmøy T, Maghazazhi AA. Expression and functional activity of chemokine receptors in glatiramer acetate (GA)-specific T cells isolated from MS patient receiving the drug GA. Human Immunol. 72: 124-134, 2011.
7. Maghazachi AA. Role of chemokines in the biology of natural killer cells. Curr. Topics Microbiol. Immunol. 341: 37-58, 2010.
8. Truta-Feles K, Lagadari M, Berod L, Cubillos S, Piehler S, Herouy Y, Barz D, K, Maghazachi AA. Norgauer J.A novel role for histamine as a modulator of γδ T cell migration and cytotoxicity: invovelment of Gi and Gs protein–coupled signaling pathways. Br. J. Pharmacol. 161: 1291-1300, 2010.
9. Rolin J, Sand KL, Knudsen E, Maghazachi AA. FTY720 and SEW2871 reverse the inhibitory effect of S1P on natural killer cell mediated lysis of K562 tumor cells and dendritic cells but not on cytokine release. Cancer Immunol. Immnuother. 59: 575-586, 2010.
10. Lagadari M, Truta-Feles K, Lehmann K, Berod L, Ziemer M, Idzko M, Barz D, Kamradt T, Maghazachi AA, Norgauer J. Lysophosphatidic acid inhibits the cytotoxic activity of NK cells: involvement of Gs protein-mediated signaling. Int. Immunol. 21: 667-677, 2009.
11. Sand KL, Rolin J, Knudsen E, Al-Falahi Y, Maghazachi AA. Modulation of natural killer cell cytotoxicity and cytokine release by the drug glatiramer acetate. Cell. Mol. Life Sci. 66: 1446-1456, 2009.
12. Al-Falahi Y, Sand KL, Knudsen E, Damaj BB, Rolin J, Maghazachi AA. Splenic natural killer cell activity in two models of experimental neurodegenerative diseases. J. Cell. Mol. Med 13: 2693-2703, 2009.
13. Lagadari M, Lehmann K, Ziemer M, Truta-Feles K, Bero L, Idzko M, Barz D, Kamradt T, Maghazachi AA, Norgauer J. Sphingosine-1-phosphate inhibits the cytotoxic activity of NK cells via Gs protein-mediated signaling. International J. Oncology 34: 287-288, 2009.
14. Nuhaily S, Damaj BB, Maghazachi AA. Oxazolone-Induced Delayed Type Hypersensitivity Reaction in the Adult Yucatan Pigs. A Useful Model for Drug Development and Validation Toxins 1: 25-36, 2009.
15. Damaj BB, Bacerra C, Esber HJ, Wen Y, Maghazachi AA. Functional expression of histamine H4 receptor in human natural killer cells, monocytes, and dendritic cells. J. Immunol. 179: 7907-7915, 2007.
16. Oz-Arslan D, Rüscher W, Myrtek D, Ziemer M, Jin Y, Damaj BB, Sorichter S, Idzko M, Norgauer J, Maghazachi AA. IL-6 and IL-8 release is mediated via multiple signaling pathways after stimulating dendritic cells with lysophospholipids. J. Leukoc. Biol. 80: 287-97, 2006.
17. Jin Y, Damaj B, Maghazachi AA. Human resting CD16-, CD16+ and IL-2-, IL-12, IL-15- or IFN-alpha-activated natural killer cells differentially respond to sphingosylphosphorylcholine, lysophosphatidylcholine and platelet-activating factor. Eur. J. Immunol. 35: 2699-2708, 2005.
18. Maghazachi AA. Insights into seven and single transmembrane spanning domain receptors and their signaling pathways in human natural killer cells. Pharmacol Rev. 57: 339-357, 2005.
19. Maghazachi AA. Compartmentalization of human natural killer cells. Mol. Immunol. 42: 523-529, 2005.
20. Gauzzi, MC, Purificato C, Donato K, JinY, Wang L, Maghazachi AA, Belardelli F, Adorini L, Gessani S. Suppressive effects of 1a,25-dihydroxyvitamin D3 on type I IFN-mediated monocyte differentiation into dendritic cells: impairment of functional activities and chemotaxis. J. Immunol. 174: 270-276, 2005.