Prof. Jianzhong Zhu

University of Pittsburgh, USA

Email: jzz9@pitt.edu

Qualifications

2000 Ph.D., Nanjing Agricultural University, Preventive Veterinary Medicine

1997 M.Sc., Yangzhou University, Preventive Veterinary Medicine

1994 B.Sc., Yangzhou University, Veterinary Medicine

Publications(Selected)

1. Umemura N*, Zhu J*, Mburu K Y, Forero A, Hsieh N P, Muthuswamy R, B Kalinski P, Ferris L R and Sarkar SN. Defective NF- headksignaling in metastatic and neck cancer cells leads to enhanced apoptosis by dsRNA. Cancer research 2012 Jan 1; 72(1): 45-55 (*equally contributed).
2. Zhu J, Coyne CB, Sarkar SN. PKC alpha regulates Sendai virus-mediated interferon induction through HDAC6 and β-catenin. EMBO J. 2011 Sep 27; 30(23): 4838-49.
3. Morosky SA, Zhu J, Mukherjee A, Sarkar SN, Coyne CB. Retinoic acid-induced gene-I (RIG-I) associates with nucleotide-binding oligomerization domain-2 (NOD2) to negatively regulate inflammatory signaling. J Biol Chem. 2011 286(32): 28574-83.
4. Zhu J*, Krishnegowda G, Li G, Gowda DC. Proinflammatory responses by glycosylphosphatidylinositols (GPIs) of Plasmodium falciparum are mainly mediated through the recognition of TLR2/TLR1. Exp Parasitol. 2011 Jul; 128(3): 205-11. (* corresponding author)
5. Zhu J, Weinburg R, Wu X, Gowda M N, Muta T, and Gowda DC. IkB- an important role in the ERK-dependent dysregulation of malaria parasite GPI-induced IL-12 expression. IUBMB Life 2012 Feb; 64(2): 187-93.
6. Zhu J, Smith K, Hsieh P, Mburu Y, Chattopadhyay, S, Sen G, and Sarkar S. A high throughput screen of TLR3-IRF3 signaling pathway modulators identifies several anti-psychotic drugs as TLR inhibitors. Journal of Immunology, 2010 184(10): 5768-76.
7. Brownile R, Zhu J, Allan B, Mutwiri G, Babiuk LA, Potter A, Griebel P. Chicken TLR21 acts as a functional homologue to mammalian TLR9 in the recognition of CpG oligodeoxynucleotides. Molecular Immunology. 2009, 46(15): 3163-70.
8. Zhu J, Wu X, Goel S, Gowda NM, Kumar S, Krishnegowda G, Mishra G, Weinberg R, Li G, Gaestel M, Muta T, Gowda DC. MAPK-activated protein kinase 2 differentially regulates plasmodium falciparum glycosylphosphatidy linositol-induced production of tumor necrosis factor-{alpha} and interleukin-12 in macrophages. J Biol Chem. 2009 Jun 5;284(23): 15750-61.
9. Zhu J, Brownile R, Liu Q, Babiuk LA and Mutwiri G. Characterization of bovine Toll-like receptor 8: ligand specificity, signaling essential sites and dimerization Molecular Immunology. 2009 Feb;46(5): 978-90.
10. Zhu J, van den Hurk, SvDL, Brownile R, Babiuk LA and Mutwiri G. Multiple molecular regions confer intracellular localization of bovine Toll-like receptor 8 Molecular Immunology. 2009 Feb;46(5): 884-92.
11. Zhu J, Brownile R, Babiuk LA and Mutwiri G. Pocine TLR8 and TLR7 are both activated by a selective TLR7 ligand, imiquimod. Molecular Immunology. 2008; 45 (11): 3238-3243.
12. Buza J, Benjamin P, Zhu J, Wilson HL, Lipford, G, Krieg, AM, Babiuk, LA, Mutriwi, GK. CD14+ cells are required for IL-12 response in bovine blood mononuclear cells activated with Toll-like receptor (TLR) 7 and TLR8 ligands. Vet Immunol Immunopathol, 2008 Dec 15; 126(3-4):273-82.
13. Zhu J, Krishnegowda G, Gowda DC Induction of proinflammatory responses in macrophages by the glycosylphosphatidylinositols of Plasmodium falciparum: the requirement of extracellular signal-regulated kinase, p38, c-Jun N-terminal kinase and NF-kappaB pathways for the expression of proinflammatory cytokines and nitric oxide. J Biol Chem. 2005; 280(9):8617-27.
14. Krishnegowda G*, Hajjar AM*, Zhu J*, Douglass EJ, Uematsu S, Akira S, Woods AS, Gowda DC. Induction of proinflammatory responses in macrophages by the glycosylphosphatidylinositols of Plasmodium falciparum: cell signaling receptors, glycosylphosphatidylinositol (GPI) structural requirement, and regulation of GPI activity. J Biol Chem. 2005; 280(9): 8606-16. ( * Equal contribution)