Prof. Seung Joon Baek
University of Tennessee, USA
Email: sbaek2@utk.edu
Qualifications
1998 Ph.D., University of Maryland School of Medicine, Human
Genetics
1991 M.Sc., Seoul National University, Agricultural Chemistry
1989 B.Sc., Seoul National University, Agricultural Chemistry
Publications (selected)
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Iguchi G, Chrysovergis K, Lee SH, Baek SJ, Langenbach R, and Eling TE.
(2009) A reciprocal Relationship Exists Between Nonsteroidal
Anti-Inflammatory Drug-Activated Gene-1 (NAG-1) and Cyclooxygenase-2. Can
Lett. Sep 18;282(2):152-8. PMID: 19375854
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Peretich A,
Cekanova M, Hurst S, Baek SJ, and Dhar M. (2009) PPAR agonists down-regulate
the expression of Atp10c mRNA during adipogenesis. Open
Obesity J. Nov 1:41-48.
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Kambe S,
Yoshioka H, Kamitani H, Watanabe T, Baek SJ, and Eling TE. (2009) The
Cyclooxygenase Inhibitor Sulindac Sulfide Inhibits EP4 Expression and
Suppresses the Growth of Glioblastoma Cells. Cancer Prev Res (Phila
Pa). Dec 2:1088-1099. PMCID: PMC2789193
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Rojsanga P,
Sukthankar M, Krisanapun C, Gritsanapan W, Lawson DB, and Baek SJ. (2010) In
vitro Anti-proliferative Activity of Alcoholic Stem Extract of Coscinium
fenestratum in human colorectal cancer cells. Exp Ther Med. Jan
1(1): 181-186. PMCID:PMC3490397
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Choi CK,
Sukhthankar M, Kim C, Lee SH, English A, Kihm KD, and Baek SJ (2010) Cell
adhesion property affected by cyclooxygenase and lipoxygenase: Opto-electric
approach. Biochem Biophys Res Commun Jan 391 (3):1385-1389.
PMCID: PMC2814420
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Sukthankar M,
Choi CK, English AE, Kim JS and Baek SJ (2010) A potential proliferative gene,
NUDT6, is down-regulated by green tea catechins at the posttranscriptional
level. J Nutr Biochem. Feb 21(2): 98-106. PMCID: PMC2840651
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Lee SH, Krisanapun
C and Baek SJ (2010) NSAID-activated gene-1 as a molecular target for
capsaicin-induced apoptosis through a novel molecular mechanism involving
GSK3beta, C/EBPbeta and ATF3. Carcinogenesis. Apr
31(4):719-728. PMCID: PMC2847092
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Cekanova M,
Lee SH, McEntee M, and Baek SJ (2010) MCC-555-induced NAG-1 expression is
mediated in part by KLF4. Eur J Pharmacol. July 637(1-3):30-37.
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Kim CH, Kwon
S, Bahn JH, Lee K, Jun S, Rack PD, and Baek SJ (2010) Effects of atmospheric
non-thermal plasma on invasion of colorectal cancer cells. App. Physics
Letter. June 96(24):243701. PMCID: PMC2902543
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Sukhthankar M,
Alberti S, and Baek SJ (2010) (-)-Epigallocatechin-3-Gallate (EGCG)
Post-transcriptionally and Post-translationally Suppresses the Cell
Proliferative Protein Trop-2 in Human Colorectal Cancer Cells. Anticancer
Res. July 30(7):2497-503. PMID: 20682974
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Close D,
Patterson S, Ripp S, Baek SJ, Sanseverino J, Sayler G (2010) Autonomous
Bioluminescent Expression of the Bacterial Luciferase Gene Cassette (lux)
in a Mammalian Cell Line. PLoS ONE. Aug 5(8): e12441.
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Kim HJ, Ryu
JH, Kim CH, Lim JW, Moon UY, Lee GH, Lee JG, Baek SJ, Yoon JH (2010) ECG
Suppresses Oxidative Stress-Induced MUC5AC Overexpression by Interaction with
EGFR. Am J Respir Cell Mol Biol. Sep 43(3):349-357.
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Lee SH, Bahn
JH, Whitlock NC, and Baek SJ (2010) Activating transcription factor 2 (ATF2)
controls tolfenamic acid-induced ATF3 expression via MAP kinase pathways. Oncogene. Sep
29(37): 5182-5192. PMCID: PMC2940954
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Kim CH, Bahn
JH, Lee SH, Kim GY, Jun SI, Lee KH and Baek SJ (2010)
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Induction of
cell growth arrest by atmospheric nonthermal plasma in colorectal cancer cells. J
Biotechnol. Dec 150(4): 530-538. PMID: 20959125.
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Zhong Y,
Krisanapun C, Lee SH, Nualsanit T, Sams C, Peungvicha P, and Baek SJ (2010)
Molecular targets of apigenin in colorectal cancer cells: Involvement of p21,
NAG-1 and p53. Eur J Cancer. Dec 46(18): 3365-3374. PMCID:
PMC2988105
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Whitlock N,
Bahn JH, Lee SH, Eling TE, and Baek SJ (2011) Resveratrol-induced apoptosis is
mediated by Early Growth Response-1, Krüppel-Like Factor 4, and Activating
Transcription Factor 3. Cancer Prev Res. Jan 4 (1):116-127.
PMCID: PMC3064282
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Krisanapun C,
Lee SH, Peungvicha P, Temsiririrkkul R, and Baek SJ (2011) Antidiabetic
properties involved ininsulinsensitivity of Abutilon indicum Sweet
are mediated by enhancement of adipocyte differentiation and activation of
GLUT1 promoter. Evid Based Complement Alternat Med. article ID
2011:167684.
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Close D, Hahn
RE, Patterson S, Baek SJ, Ripp SA, and Sayler G (2011) Comparison Of Human
Optimized Bacterial Luciferase, Firefly Luciferase, And Green Florescent
Protein For Continuous Imaging Of Cell Cultures And mouse Models.J Biomed
Opt. Apr 16(4):047003. PMID: 21529093
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Flatland B,
Fry MM, Baek SJ, Bahn JH, LeBlanc CJ, Dunlap JR, Carroll RC, Kosiba DJ,
Millsaps DJ, and Schleis SE. (2011) May-Hegglin Anomaly in a Dog. Vet.
Clin. Pathol. June 40(2):207-214. PMID:21554370.
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Margraves CH,
Kihm KD, Yoon SY, Choi CK, Lee SH, Liggett JL, Baek SJ. (2011) Simultaneous Measurements
of Cytoplasmic Viscosity and Intracellular Vesicle Sizes for Live Human Brain
Cancer Cells. Biotechnol Bioeng. Oct 108(10):2504-2508.
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Huang EC, Chen
G, Baek SJ, McEntee MF, Collier JJ, Minkin S, Biggerstaff J and Whelan J.
(2011) Zyflamend® Reduces the Expression of Androgen Receptor in a Model of
Castrate-Resistant Prostate Cancer. Nutr. Cancer. Nov
63(8):1287-1296.
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Nualsanit T,
Rojanapanthu P, Gritsanapan, W, Kwankitpraniti T, Min KW, and
Baek SJ. (2011) Damnacanthal-induced Anti-inflammation is Associated with
Inhibition of NF-κB Activity. Inflamm Allergy Drug Targets. Dec
10(6):455-463.
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Kang SU, Shin
YS, Hwang HS, Baek SJ, Lee SH, and Kim CH. (2012) Tolfenamic Acid Induces
Apoptosis and Growth Inhibition in Head and Neck Cancer: Involvement of NAG-1
Expression. Apr 7(4): e34988. PLoS ONE.
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Lee SH,
Richardson RL, Dashwood RH, and Baek SJ (2012) Capsaicin represses
transcriptional activity of β-catenin in human colorectal cancer cells. J
Nutr Biochem. June 23(6): 646-655. PMCID:PMC3197951.
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Nualsanit T,
Rojanapanthu P, Gritsanapan W, Lee SH, Lawson DB and Baek SJ (2012)
Damnacanthal, a Noni component, exhibits anti-tumorigenic
activity in human colorectal cancer cells. J Nutr Biochem. Aug 23(8):
915-923.
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Min KW, Zhang
X, Imchen T, and Baek SJ (2012) MCC-555 Enhances Anti-tumorigenic Activity in
Pancreatic Cancer Cells via Multiple Targets. Toxicol Appl Pharmacol.
Sep 263(2):225-232. PMCID:PMC3443873.
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Zhang X, Min
KW, Wimalasena J, and Baek SJ (2012) Cyclin D1 degradation and p21 induction
contribute to growth inhibition of colorectal cancer cells induced by
Epigallocatechin-3-gallate. J Can Res Clin Oncol. Dec
138(12):2051-60.
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Lee SH, Min
KW, Zhang X, and Baek SJ. (2013) 3,3'-diindolylmethane induces activating
transcription factor 3 (ATF3) via ATF4 in human colorectal cancer cells. J
Nutr Biochem. Apr 24(4): 664-671. PMCID:PMC3481000
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Kim JM, Kosak
JP, Lim JK, Kissling G, Germolec DR, Zeldin DC, Bradbury JA, Baek SJ and Eling
TE (2013) NAG-1/GDF15 transgenic mouse has less white adipose tissue and a
reduced inflammatory response. Mediators Inflamm. May 2013
Article ID 641851. PMCID: PMC3662179.
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Pandith H,
Zhang X, Thongpraditchote S, Wongkrajang Y, Gritsanapan W and Baek SJ. (2013)
Effect of Siam Weed Extract and its Bioactive Component Scutellarein
Tetramethyl Ether on Anti-inflammatory Activity. J Enthopharm. May
147(2): 434-441. PMID: 23535395
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Kang SU, Lee
B-S, Lee S-H, Baek SJ, Shin YS, and Kim C-H (2013) Expression of
NSAID-activated gene-1 by EGCG in head and neck cancer: involvement of
ATM-dependent p53 expression. J Nutr Biochem. June 24(6): 986-999.
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Pandith H,
Zhang X, Liggett J, Min KW, Gritsanapan W and Baek SJ. (2013) Effect of
Chromolaena Odorata Extract on Wound Healing Activity. ISRN Dermatol. Aug
2013: 168269. PMCID: PMC3747403.
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Imchen T,
Manasse J, Min KW, Baek SJ. (2013) Characterization of PPAR dual ligand MCC-555
in AOM-induced colorectal tumorigenesis. Exp Toxicol Pathol. Sep
65(6): 919-924. PMCID: PMC3644347.
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Jeong JB, Choi
J, Baek SJ, and Lee SH. (2013) Reactive oxygen species mediate tolfenamic
acid-induced apoptosis in human colorectal cancer cells. Arch Biochem
Biophys. Sep 537(2): 168-175. PMID: 23896517.
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Jeong JB, Yang
X, Clark R, Choi J, Baek SJ, and Lee SH. (2013) Tolfenamic acid-induced
apoptosis is mediated by NF-κB activation in human colorectal cancer cells. Carcinogenesis. Oct
34(10): 2350-2360. PMID: 23784084.
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Zhang X, Lee
SH, Min KW, McEntee MF, Jeong JB, Li Q, and Baek SJ. (2013) Nonsteroidal
anti-inflammatory drug tolfenamic acid inhibits colorectal tumorigenesis via
endoplasmic reticulum stress. Cancer Prev Res. Dec 6(12):1-11.
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Liggett JL,
Choi CK, Donnell RL, Kihm KD, Kim JS, Min KY, Noegel AA, and Baek SJ (2014)
Nonsteroidal anti-inflammatory drugs suppress structural protein Nesprin-2
expression in colorectal cancer cells. Biochim Biophys Acta. Jan
1840(1): 322-331. PMID: 24080406.
Profile Details
http://www.vet.utk.edu/carcinogenesis_lab/index.php