Biography

Prof. Jonathan B. Angel

University of Ottawa, Canada


Email: jangel@ohri.ca


Qualifications


1988  M.D., University of Toronto School of Medicine

1984  B.Sc., University of Toronto, University College


Publications (selected)

  1. P.A. Brown,J.B. Angel. “Granulocyte-macrophage colony stimulating factor as an immune-based therapy in HIV infection” J Immun Based Ther Vaccines 3(1): 3, 2005.
  2. C.L. Cooper, H.L. Davis,J.B. Angel, M.L. Morris, S.M. Elfer, I. Seguin, A.M. Krieg, D.W. Cameron. “CPG 7909 adjuvant improves HBV vaccine seroprotection in antiretroviral treated HIV-infected adults.” AIDS 19(14): 1473-1479, 2005.
  3. C.D. Young,J.B. Angel. “Optimization of culture and storage conditions for an in vitro system to evaluate thymocyte phenotype and function.” J Immunol Methods 312: 157-166, 2006.
  4. G.B. Pott, C.A. Sailer, R. Porat,R.L. Peskind, A.C. Fuchs,J.B. Angel, P.R. Skolnik, M.A. Jacobson, M.F. Giordano, A. LeBeaut,P.C. Grint, C.A. Dinarello and L. Shapiro. “Effect of a Four-Week Course of Interleukin-10 on Cytokine Production in a Placebo-Controlled Study of HIV-1-Infected Subjects.” Eur Cytokine Netw 18(2): 49-58, 2007.
  5. A. Vranjkovic, A.M. Crawley,  K. Gee, A. Kumar,J.B. Angel “IL-7 decreases IL-7 receptor- (CD127) expression and induces shedding of CD127 by human CD8+ T cells.”  Internat Immunol 19(12): 1329-1339, 2007.
  6. C.L. Cooper,J.B. Angel, I. Seguin, H.L. Davis, D.W. Cameron “CPG 7909 Adjuvant plus Hepatisis B Virus Vaccination in HIV-Infected Adults Achieves Long-Term Seroprotection for Up to 5 Years.” Clin Infect Dis 46: 1310-1314, 2008.
  7. J.B. Angel, C.L. Cooper, J. Clinch, C.D. Young, A. Chenier, K.G. Parato, M. Lautru, H. Davis, D.W. Cameron. “CpG increases vaccine antigen-specific cell-mediated immunity when administered with hepatitis B vaccine in HIV infection”. J Immun Based Ther Vaccines 6: 4, 2008.
  8. A.M. Crawley,T.Katz, K.P. Parato,J.B.Angel“IL-2 receptor gamma chain cytokines differentially affect human CD8+CD127+and CD8+CD127-T-cell division and susceptibility to apoptosis.” Int Immunol 21(1): 29-42, 2009.
  9. J. B. Angel, W. Greaves, D. Ward, A. Rodriguez, D. Scevola, L. Nieto, E. De Jesus. “Virologic and Immunologic Activity of PEG Intron in HIV Disease” AIDS 23: 2431-2438, 2009.
  10. A.M. Crawley, S. Faucher,J.B. Angel. “Soluble IL-7 R (sCD127) inhibits IL-7 activity and is increased in HIV infection.” J Immunol 184: 4679-4687, 2010.
  11. A.M. Crawley, A. Vranjkovic, C. Young,J.B. Angel. “Interleukin-4 downregulates CD127 expression and activity on human thymocytes and mature CD8+ T-cells.” Eur J Immunol 40: 1396-1407, 2010
  12. A.M. O’Connor, A.M. Crawley,J.B. Angel. “IL-7 enhances memory CD8+ T cell recall responses in health but its activity is impaired in HIV infection.” Immunology 131(4): 525-536, 2010
  13. J.B. Angel, J.-P. Routy, C. Tremblay, D. Ayers, R. Woods, J. Singer, N. Bernard, C. Kovacs, F. Smaill, S. Gurunathan, R.-P. Sekaly. “A Randomized Controlled Trial of HIV Therapeutic Vaccination Using ALVAC With or Without Remune” AIDS 25: 731-739, 2011
  14. J.M. Langley, F. Aoki, B.J. Ward, A. McGeer,J.B. Angel, G. Stiver, I. Gorfinkel, D. Shu, L. White, B. Lasko, P. Dzongowski, K. Papp, M. Alexander, G. Boivin, L. Fries. “A nasally administered trivalent inactivated influenza vaccine is well tolerated, stimulates both mucosal and systemic immunity, and potentially protects against influenza illness.” Vaccine 29(10): 1921-1928, 2011
  15. A. Vranjkovic, A.M. Crawley, A. Patey,J.B. Angel. “IL-7-dependent STAT-5 activation and CD8+ T-cell proliferation are impaired in HIV infection” J Leukoc Biol 89 (4): 499-506, 2011
  16. C. Young,J.B. Angel. “HIV infection of thymocytes inhibits IL-7 activity without altering CD127 expression.” Retrovirology 8 (72): 1-6, 2011
  17. C. Costiniuk,J.B. Angel. “ALVAC-HIV as a prophylactic and therapeutic vaccine: highlights from over a decade of clinical trials” Future Virol 6(12), 2011
  18. A. Crawley,J.B. Angel. “The influence of HIV on CD127 expression and its potential implications of IL-7 therapy.” Seminars in Immunology 24(3): 231-240, 2012.
  19. J. Spaans, J.P. Routy, C. Tremblay, J. Singer, N. Bernard, S. Gurunathan, R.P. Sekaly,J.B. Angel. “Optimizing the efficiency of therapeutic HIV vaccine trials: A case for CTN173” Trials in Vaccinology 1: 21-26, 2012.
  20. J.P. Routy, C. Tremblay,J.B. Angel, B. Trottier, D. Rouleau, J.G. Baril, M. Harris, S. Trottier, J. Singer, M.R. Boulassel. “Valproic acid in association with highly active antiretroviral therapy for reducing HIV-1 reservoir: Results from a multicentre randomized clinical study (CTN 205)” HIV Med 13(5): 291-296, 2012.
  21. A. Crawley,J. B. Angel. “Expression of γ-chain cytokine receptors on CD8+ T cells in HIV infection with a focus on IL-7Rα (CD127).” Immunol Cell Biol 90(4):379-987, 2012.
  22. A. Vranjkovic, A.M. Crawley,J.B. Angel. “In vitro HIV-1 infection indirectly alters CD127 expression on CD8+ T-cells.” AIDS Res Hum Retroviruses 28(3): 295-298, 2012.

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