Prof. Jonathan B. Angel
University of Ottawa, Canada
Email: jangel@ohri.ca
Qualifications
1988 M.D., University of Toronto School of Medicine
1984 B.Sc., University of Toronto, University College
Publications (selected)
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P.A. Brown,J.B. Angel. “Granulocyte-macrophage colony stimulating factor as an immune-based therapy in HIV infection” J Immun Based Ther Vaccines 3(1): 3, 2005.
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C.L. Cooper, H.L. Davis,J.B. Angel, M.L. Morris, S.M. Elfer, I. Seguin, A.M. Krieg, D.W. Cameron. “CPG 7909 adjuvant improves HBV vaccine seroprotection in antiretroviral treated HIV-infected adults.” AIDS 19(14): 1473-1479, 2005.
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C.D. Young,J.B. Angel. “Optimization of culture and storage conditions for an in vitro system to evaluate thymocyte phenotype and function.” J Immunol Methods 312: 157-166, 2006.
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G.B. Pott, C.A. Sailer, R. Porat,R.L. Peskind, A.C. Fuchs,J.B. Angel, P.R. Skolnik, M.A. Jacobson, M.F. Giordano, A. LeBeaut,P.C. Grint, C.A. Dinarello and L. Shapiro. “Effect of a Four-Week Course of Interleukin-10 on Cytokine Production in a Placebo-Controlled Study of HIV-1-Infected Subjects.” Eur Cytokine Netw 18(2): 49-58, 2007.
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A. Vranjkovic, A.M. Crawley, K. Gee, A. Kumar,J.B. Angel “IL-7 decreases IL-7 receptor- (CD127) expression and induces shedding of CD127 by human CD8+ T cells.” Internat Immunol 19(12): 1329-1339, 2007.
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C.L. Cooper,J.B. Angel, I. Seguin, H.L. Davis, D.W. Cameron “CPG 7909 Adjuvant plus Hepatisis B Virus Vaccination in HIV-Infected Adults Achieves Long-Term Seroprotection for Up to 5 Years.” Clin Infect Dis 46: 1310-1314, 2008.
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J.B. Angel, C.L. Cooper, J. Clinch, C.D. Young, A. Chenier, K.G. Parato, M. Lautru, H. Davis, D.W. Cameron. “CpG increases vaccine antigen-specific cell-mediated immunity when administered with hepatitis B vaccine in HIV infection”. J Immun Based Ther Vaccines 6: 4, 2008.
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A.M. Crawley,T.Katz, K.P. Parato,J.B.Angel“IL-2 receptor gamma chain cytokines differentially affect human CD8+CD127+and CD8+CD127-T-cell division and susceptibility to apoptosis.” Int Immunol 21(1): 29-42, 2009.
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J. B. Angel, W. Greaves, D. Ward, A. Rodriguez, D. Scevola, L. Nieto, E. De Jesus. “Virologic and Immunologic Activity of PEG Intron in HIV Disease” AIDS 23: 2431-2438, 2009.
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A.M. Crawley, S. Faucher,J.B. Angel. “Soluble IL-7 R (sCD127) inhibits IL-7 activity and is increased in HIV infection.” J Immunol 184: 4679-4687, 2010.
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A.M. Crawley, A. Vranjkovic, C. Young,J.B. Angel. “Interleukin-4 downregulates CD127 expression and activity on human thymocytes and mature CD8+ T-cells.” Eur J Immunol 40: 1396-1407, 2010
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A.M. O’Connor, A.M. Crawley,J.B. Angel. “IL-7 enhances memory CD8+ T cell recall responses in health but its activity is impaired in HIV infection.” Immunology 131(4): 525-536, 2010
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J.B. Angel, J.-P. Routy, C. Tremblay, D. Ayers, R. Woods, J. Singer, N. Bernard, C. Kovacs, F. Smaill, S. Gurunathan, R.-P. Sekaly. “A Randomized Controlled Trial of HIV Therapeutic Vaccination Using ALVAC With or Without Remune” AIDS 25: 731-739, 2011
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J.M. Langley, F. Aoki, B.J. Ward, A. McGeer,J.B. Angel, G. Stiver, I. Gorfinkel, D. Shu, L. White, B. Lasko, P. Dzongowski, K. Papp, M. Alexander, G. Boivin, L. Fries. “A nasally administered trivalent inactivated influenza vaccine is well tolerated, stimulates both mucosal and systemic immunity, and potentially protects against influenza illness.” Vaccine 29(10): 1921-1928, 2011
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A. Vranjkovic, A.M. Crawley, A. Patey,J.B. Angel. “IL-7-dependent STAT-5 activation and CD8+ T-cell proliferation are impaired in HIV infection” J Leukoc Biol 89 (4): 499-506, 2011
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C. Young,J.B. Angel. “HIV infection of thymocytes inhibits IL-7 activity without altering CD127 expression.” Retrovirology 8 (72): 1-6, 2011
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C. Costiniuk,J.B. Angel. “ALVAC-HIV as a prophylactic and therapeutic vaccine: highlights from over a decade of clinical trials” Future Virol 6(12), 2011
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A. Crawley,J.B. Angel. “The influence of HIV on CD127 expression and its potential implications of IL-7 therapy.” Seminars in Immunology 24(3): 231-240, 2012.
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J. Spaans, J.P. Routy, C. Tremblay, J. Singer, N. Bernard, S. Gurunathan, R.P. Sekaly,J.B. Angel. “Optimizing the efficiency of therapeutic HIV vaccine trials: A case for CTN173” Trials in Vaccinology 1: 21-26, 2012.
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J.P. Routy, C. Tremblay,J.B. Angel, B. Trottier, D. Rouleau, J.G. Baril, M. Harris, S. Trottier, J. Singer, M.R. Boulassel. “Valproic acid in association with highly active antiretroviral therapy for reducing HIV-1 reservoir: Results from a multicentre randomized clinical study (CTN 205)” HIV Med 13(5): 291-296, 2012.
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A. Crawley,J. B. Angel. “Expression of γ-chain cytokine receptors on CD8+ T cells in HIV infection with a focus on IL-7Rα (CD127).” Immunol Cell Biol 90(4):379-987, 2012.
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A. Vranjkovic, A.M. Crawley,J.B. Angel. “In vitro HIV-1 infection indirectly alters CD127 expression on CD8+ T-cells.” AIDS Res Hum Retroviruses 28(3): 295-298, 2012.
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