Dr. Boris Z. Simkhovich

Good Samaritan Hospital

USA

 

Email: simkhovi@usc.edu

 

Qualifications

 

1988, Doctor of Medical Sciences (Cardiovascular Pharmacology and Pathophysiology), Institute for General Pathology and Pathophysiology, Academy of Medical Sciences, Moscow, USSR.

1975-1976, Research Fellowship (Biochemistry and Molecular Biology), Institute for Medical and Biological Chemistry, Academy of Medical Sciences, Moscow, USSR.

1971– 1974, Ph.D. in Biochemistry, Riga Medical School, Riga, Latvia.

1965-1971, Resident, Internal Medicine, Riga Medical School, Riga, Latvia

1965-1971, M.D., Riga Medical School, Riga, Latvia.

 

Selected Publications

Simkhovich BZ, Zamaraeva TV, Zelchan GI, Lukevics E, Mazurov VI: Effect of silatranes on collagen biosynthesis in cartilaginous tissue of chick embryos. Biokhimiia, 42:1128-1132, 1977.

 

Simkhovich BZ, Slutski LI, Dombrovskaya LE, Gilev AP, Zelchan GI, Lukevics E: Effect of silicon organic compounds on protein synthesis in the granulation fibrous tissue. Bulleten Eksperimentalnoij Biologii i Meditsini, 87:153-155, 1978.

 

Simkhovich BZ: Adenylate cyclase activity in Ehrlich ascites carcinoma cells in vitro. Voprosy Meditsinskoij Khimii, 24:768-774, 1978.

 

Slutski LI, Simkhovich BZ: Molecular heterogeneity of collagen.(Review).Uspekhi Sovremenoij Biologii, 89:58-73, 1980

 

Simkhovich BZ, Selina AV: Effect of cyclic adenosine-3,5-monophosphate and its dibutyryl analoq on the biosynthesis of macromolecules in actively proliferating cells. Bulleten Eksperimentalnoij Biologii i Meditsini, 90:320-322, 1980.

 

Simkhovich BZ, Slutski LI: Molecular heterogeneity of  collagen from skin of rats in early postnatal period. Voprosy Metitsinskoij Khimii, 28:110-114, 1982.

 

Nagobad VY, Simkhovich BZ, Parinov VY, Gilev AP: Furagin and Furadonin excretion in patients with chronic pyelonephritis. Urologiia i Nefrologiia, 6:49-52, 1982.

 

Simkhovich BZ, Kimenis AA: The mechanism of action of cardiovascular drugs- calcium antagonists. (Review). Khimiko-Farmacevticheskij Zhurnal, 2:134-147, 1984.

 

Velena AH, Dubur GJ, Vitolina RO, Kimenis AA, Selga MJ, Zarinsh GV, Narusevicius EV, Macianskiene RA, Gendvilene VI, Simkhovich BZ: Effect of ryodipine on electromechanical parameters of heart and vessels, cAMP phosphodiesteraseactivity and swelling-contraction cycle of mitochondria. Arzneimittel-Forschung (Drug Research), 35:907-914, 1985.

 

Simkhovich BZ, Meirena DV, Hagi HB, Kalvins IJ, Lukevics E. Influence of a new structural analoq of gamma-butyrobetaine- 3-(2.2.2-trimethylhydrazinium) propionate on carnitine-dependent fatty acids oxidation and some indexes of energy metabolism in myocardium. Voprosy Meditsinskoij Khimii, 32:72-76, 1986.

 

Odinec AG, Simkhovich BZ, Kimenis AA. Pharmacological effects and mechanism of action of 1,4-dihydropyridine derivatives on cardiovascular system. (Review). Khimiko-Farmacevticheskij Zhurnal, 12:1443-1451, 1986

 

Simkhovich BZ, Meirena DV, Hagi HB, Kalvins IJ, Lukevics E. Biochemical characterization of the antiischemic effects of a new structural analoq of gamma-butyribetaine, 3-(2,2,2-trimethylhydrazinium) propionate. Farmakologiia i Toksikologiia, 50:100-104, 1987.

 

Simkhovich BZ, Vitolina RO, Stivrina MI, Shutenko ZV, Meirena DV, Kimenis AA, Kalvins IJ, Lukevics E: Prevention of ischemic myocardium damage by reduction in intracellular free carnitine concentration. Kardiologiia, 27:85-88, 1987.

 

Simkhovich BZ, Shutenko ZV, Meirena DV, Khagi KB, Mezapuke RJ, Molodchina TN, Kalvins IJ, Lukevics E: 3-(2.2.2-Trimethylhydrazinium) propionate (THP) a novel gamma-butyrobetaine hydroxylase inhibitor with cardioprotective properties. Biochem Pharmacol, 37:195-202, 1988.

 

Simkhovich BZ, Meirena DV, Shutenko ZV, Hagi HB, Briede JL, Kalvins LJ, Lukevics E: Effect of D,L-carnitine and 3-(2,2,2-trimethylhydrazinium) propionate, an inhibitor of gamma-butyrobetaine hydroxylase,on isoproterenol induced impairments in myocardium metabolism. Voprosy Meditsinskoij Khimii, 34:30-34, 1988.

 

Simkhovich BZ, Mezapuke RJ, Dubur GJ: Study of biochemical effects of riodipine (foridone) a new calcium antagonist, 1,4- dihydropyridine derivative.Farmakologiia i Toksikologiia, 51:30-34, 1988.

 

Kagan TI, Lidak MY, Meirena DV, Simkhovich BZ: Search of antitumor agents among synthetic polycations. (Review). Khimiko-Farmacevticheskij Zhurnal, 6:646-656, 1988

 

Shutenko ZV, Simkhovich BZ, Meirena DV, Kalvins IJ, Lukevics E: Regulation of carnitine-dependent metabolism of fatty acids in rat myocardium using 3-(2,2,2-trimethyl hydrazinium) propionate. Voprosy Meditsinskoij Khimii, 35:59-64, 1989.

 

Simkhovich BZ, Meirena DV, Khagi KB, Freimanis YF: Effect of doprostone on fatty acid metabolism disturbances in therat heart caused by adrenergic stimuli. Farmakologiia i Toksikologiia, 52:24-27, 1989.

 

Simkhovich BZ, Briede YL, Ozola RA, Meirena DV, Kalvinsh IY, Lukevits EY: Effect of mildronate on the rat heart contractility impairment induced by excess free fatty acids and ischemia. Farmakologiia i Toksikologiia, 53:27-29, 1990.

 

Kagan TI, Simkhovich BZ, Kalvins IJ, Lukevics EJ: Effect of the inhibitor of carnitine-dependent metabolism mildronate on fatty acid oxidation in liver mitochondria of intact rats. Voprosy Meditsinskoj Khimii, 37:44-46, 1991.

 

Shutenko ZV, Priyedena IA, Mezhapuke RY, Simkhovich BZ, Kalvinsh IJ, Lukevits EY: Effect of a carnitine biosynthesis inhibitor mildronate on some parameters of lipid metabolism in rats. Farmakologiia i Toksikologiia, 54:55-56, 1991.

 

Simkhovich BZ, Meirena DV, Khagi KB, Shutenko ZV, Molodchina TN, Kalvinsh IJ, Lukevich EJ: Effect of mildronate on carnitine-dependent and carnitine-independent ketogenesis in rats. Farmakologiia i Toksikologiia, 54:41-42, 1991.

 

Simkhovich BZ, Hale SL, Kloner RA: Effect of ischemic preconditioning on carnitine-linked metabolism in the rabbit heart. Coronary Artery Disease, 3:141-147, 1992.

 

Simkhovich BZ, Hale SL, Ovize M, Przyklenk K, Kloner RA: Ischemic preconditioning and long-chain acyl carnitine in the canine heart. Coronary Artery Disease, 4:387-392, 1993.

 

Bauer B, Simkhovich BZ, Kloner RA, Przyklenk K: Does preconditioning protect the coronary vasculature from subsequent ischemia/reperfusion injury? Circulation, 88:659-671, 1993.

 

Simkhovich BZ, Kloner RA, Alker KJ, Giaconi J: The time course of direct cardiotoxic effects of high cocaine concentration in isolated rabbit hearts. J. Cardiovasc Pharmacol, 23:509-516, 1994.

 

Przyklenk K, Simkhovich BZ, Bauer B, Kloner RA: Deterioration in myocardial blood flow during relief of sustained ischemia is not explained by release of endothelin. Basic Res Cardiol. 89:260-269, 1994.

 

Przyklenk K, Aoki A, Bellows S, Kleindienst D, Zubiate P , Hale SL, Simkhovich BZ, Kloner RA, Kay GL: Stunned myocardium following prolonged cardiopulmonary bypass: Effect of warm versus cold cardioplegia in the canine model. J Card Surg. 9:506-516, 1994.

 

Bellows SD, Hale SL, Simkhovich BZ, Kay GL, Kloner RA: Do antioxidant vitamins reduce infarct size following acute myocardial ischemia/reperfusion. Cardiovascular Drugs and Therapy, 9:117-123, 1995.

 

Przyklenk K, Sussman MA, Simkhovich BZ, Kloner RA: Does ischemic preconditioning trigger translocation of protein kinase C. Circulation, 92:1546-1557, 1995.

 

Simkhovich BZ, Whittaker P, Przyklenk K, Kloner RA: Transient pre-ischemic acidosis protects the isolated rabbit heart subjected to 30 minutes, but not 60 minutes, of global ischemia. Basic Research in Card, 90:397-403, 1995.

 

Simkhovich BZ, Przyklenk K, Hale SL, Patterson M, Kloner RA: Diretct evidence that ischemic preconditioning does not cause protein kinase C translocation in rabbit heart. Cardiovascular Research, 32:1064-1070, 1996.

 

Kamlot A, Bellows SD, Simkhovich BZ, Hale SL, Aoki A, Kloner RA, Kay GL: Is warm retrograde blood cardioplegia better than cold for myocardial protection. The Annals of Thor Sur, 63:98-104, 1997.

 

Simkhovich BZ, Przyklenk K, Kloner RA: Role of protein kinase C as a cellular mediator of ischemic preconsitioning: a critical review. Cardiovasc Res, 40:9-22, 1998.

 

Simkhovich BZ, Kloner RA, Przyklenk K: Temporal changes in the subcellular distribution of protein linase C in rabbit heart during global ischemia. Basic Res Cardiol, 93:122-126, 1998.

 

Przyklenk K, Simkhovich BZ, Bauer B, Hata K, Zhao L, Elliott GT, Kloner RA: Cellular mechanisms of infarct size reduction with ischemic preconditionin. Ann NY Acad Sci, 874:192-210, 1999.

 

Bauer B, Simkhovich BZ, Kloner RA, Przyklenk K: Preconditioning-induced cardioprotection and release of second messenger inositol (1,4,5)-triphosphate are abolished by neomycin in rabbit heart. Bas Res Cardiol, 94:31-40, 1999..

 

Gysembergh A, Simkhovich BZ, Kloner RA, Przyklenk K: p38 MAPCK activity is no increased early during sustained coronary occlusion in preconditioned versus control rabbit heart. J Mol Cell Cardiol, 33:681-690, 2001.

 

Simkhovich BZ, Abdishoo S, Poizat C, Hale SL, Kedes KH, Kloner RA: Gene activity changes in ischemically preconditioned rabbit heart: gene discovery array study. Heart Dis, 4:63-69, 2002.

 

Reffelmann T, Dow JS, Dai W, Hale SL, Simkhovich BZ, Kloner RA. Transplantation of neonatal cardiomyocytes after permanent coronary artery occlusion increases blood flow of infracted myocardium. J Mol Cell Cardiol, 25:607-613, 2003.

 

Simkhovich BZ, Marjoram P, Poizat C, Kedes L, Kloner RA: Brief episode of ischemia activates protective genetic program in rat heart: a gene chip study. Cardiovasc Res, 59:450-459, 2003.

 

Simkhovich BZ, Marjoram P, Poizat C, Kedes L, Kloner RA: Age-related changes of cardiac gene expression following myocardial ischemia/reperfusion. Arch Biochem Biophys, 420:268-278, 2003.

 

Przyklenk K, Li G, Simkhovich BZ, Kloner RA: Mechanisms of myocardial ischemic preconditioning are age-related: protein kinase C does not play a requisite role in old rabbits. J Appl Physiol 95:2563-2569, 2003.

 

Simkhovich BZ, Kloner RA, Poizat C, Marjoram P, Kedes LH: Gene expression profiling – a new approach in the study of myocardial ischemia. Cardiovasc Pathol, 12:180-185, 2003.

 

Kedes L, Kloner R, Kong K, Poizat C, Simkhovich BZ, Iso T, Hamamori Y: New cellular and molecular approaches for the treatment of cardiac disease. Sem in Neph,; 24:437-440, 2004.

 

Simkhovich BZ, Hale SL, Kloner RA: Metabolic mechanism by which mild regional hypothermia preserves ischemic tissue. J Cardiovasc Pharmacol Therapeut, 9:83-90, 2004.

 

Dow J, Simkhovich BZ, Kedes L, Kloner RA: Washout of transplanted cells from the heart: A potential new hurdle for cell transplantation therapy. Cardiovasc Res, 67:301-307, 2005.

 

Kloner RA, Simkhovich BZ: Benefits of exercise prior to myocardial infarction. J Am Coll Cardiol, 45:939-940, 2005.

 

Sesti C, Simkhovich BZ, Kalvinsh I, Kloner RA. Mildronate, a novel fatty acid oxidation inhibitor and anti-anti-anginal agent, reduces myocardial infarct size independent of hemodynamics. J Cardiovasc Pharmacol, 2006, 47: 493-499.