Prof. Jean Sévigny

Department of Microbiology-Infectiology and Immunology

Faculty of Medicine, University Laval, Canada

Email: Jean.Sevigny@crchul.ulaval.ca

Qualifications

2010    Professor, Dept. of Microbiology-Infectiology and Immunology, University Laval, Canada 
2009   Associate Professor, Dept. Anatomy & Physiology, University Laval, Canada
2006   Assistant Professor, Dept. Anatomy & Physiology, University Laval, Canada
1997   Ph.D., Biology, Sherbrooke University
1992   M.Sc., Microbiology, Sherbrooke University
1988   B.Sc., Biology (Biotechnology), Sherbrooke University

Publications (Selected)

1. Vekaria, R.M., D.G. Shirley, J. Sévigny & R.J. Unwin. (2006) Immunolocalization of ectonucleotidases along the rat nephron. Am. J. Physiol. – Renal Physiol. 290(2): F550-60. 
2. Mishra, S.K., N. Braun, V. Shukla, M. Füllgrabe, C. Schomerus, H.orst-W.erner Korf, C. Gachet, Y. Ikehara, J. Sévigny, S.C. Robson & H. Zimmermann. (2006) Extracellular nucleotide signaling in adult neural stem cells: synergism with growth factor-mediated cellular proliferation. Development 133(4): 675-84. 
3. Wink, M.R., E. Braganhol, A.S.K. Tamajusuku, G. Lenz, L.F. Zerbini, T.A. Libermann, J. Sévigny, A.M.O. Battastini & S.C. Robson. (2006) Nucleoside triphosphate diphosphohydrolase-2 (NTPDase2/CD39L1) is the dominant ectonucleotidase expressed by rat astrocytes. Neuroscience 138: 421-32. 
4. Bartel, D.L., S.L. Sullivan, E.G. Lavoie, J. Sévigny & T.E. Finger. (2006) Nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) is the ecto-ATPase of type I cells in taste buds. J. Comp. Neurol. 497(1): 1-12. 
5. Nahum, V., M. Tulapurkar, S.A. Lévesque, J. Sévigny, G. Reiser & B. Fischer. (2006) Diadenosine- and diuridine-poly(borano)phosphate analogues: synthesis, chemical and enzymatic stability, and activity at P2Y₁ and P2Y₂-receptors. J. Med. Chem. 49(6): 1980-90. 
6. Sasseville, A., N. Paquet, J. Sévigny & M. Hébert. (2006) Blue blocker glasses impede the capacity of bright light to suppress melatonin production. J. Pineal Res. 41(1): 73-8.
7.  Sharon, E., S.A. Lévesque, M. Munkonda, J. Sévigny, D. Ecke, G. Reiser & B. Fischer. (2006) Fluorescent N²,N3--adenosine nucleoside and nucleotide Probes: Synthesis, spectroscopic properties, and biochemical evaluation. ChemBioChem. 7(9): 1361-74. 
8. Fausther, M., J. Lecka, F. Kukulski, S.A. Lévesque, J. Pelletier, H. Zimmermann, J.A. Dranoff & J. Sévigny. (2007) Cloning, purification, and identification of the liver canalicular ecto-ATPase as NTPDase8. Am. J. Physiol. Gastrointest. Liver Physiol. 292: G785-95.
9. Kukulski, F., F. Ben Yebdri, J. Lefebvre, M. Warny, P.A. Tessier & J. Sévigny. (2007) Extracellular nucleotides mediate LPS-induced neutrophil migration in vitro and in vivo. J. Leukoc. Biol. 81(5): 1269-75. 
10. Barat, C., G. Martin, A.R. Beaudoin, J. Sévigny & M.J. Tremblay. (2007) The nucleoside triphosphate diphosphohydrolase-1/CD39 is incorporated into human immunodeficiency type 1 particles, where it remains biologically active. J. Mol. Biol. 371(1): 269-82. 
11. Kittel, A., B. Sperlágh, J. Pelletier, J. Sévigny & T.L. Kirley. (2007) Transient changes in the localization and activity of ecto-nucleotidases in rat hippocampus following lipopolysaccharide treatment. Int. J. Dev. Neurosci. 25(5): 275-82. 
12. Lévesque, S.A., E.G. Lavoie, J. Lecka, F. Bigonnesse & J. Sévigny. (2007) Specificity of the ecto-ATPase inhibitor ARL 67156 on major ecto-nucleotidases. Br. J. Pharmacol. 152(1): 141-50. 
13. Lu, W., D. Reigada, J. Sévigny & C.H. Mitchell. (2007) Stimulation of the P2Y₁ receptor up-regulates nucleoside-triphosphate diphosphohydrolase-1 in human retinal pigment epithelial cells. JPET 323(1): 157-64. 
14. Li, Z.haodong, J.A. Dranoff, E.P. Chan, M. Uemura, J. Sévigny & R.G. Wells. (2007) TGF-b1 and substrate stiffness regulate portal fibroblast activation in culture. Hepatology 46(4): 1246-56. 
15. Munkonda, M.N., G. Kauffenstein, F. Kukulski, S.A. Lévesque, C. Legendre, J. Pelletier, E.G. Lavoie, J. Lecka & J. Sévigny. (2007) Inhibition of human and mouse plasma membrane bound NTPDases by P2 receptor antagonists. Biochem. Pharmacol. 74: 1524-34. 
16. [Co-first authors : Yu, J., E.G. Lavoie], N. Sheung, J.J. Tremblay, J. Sévigny & J.A. Dranoff. (2008) Il-6 downregulates transcription of NTPDase2 via specific promoter elements. Am. J. Physiol. Gastrointest. Liver Physiol. 294(3): G748-56.  
17. Kataoka S., R. Yang, Y. Ishimaru, H. Matsunami, J. Sévigny, J.C. Kinnamon & T.E. Finger. (2008) The candidate sour taste receptor, PKD2L1, is expressed by type III taste cells in the mouse. Chem. Senses 33(3): 243-54.  
18. Brunschweiger, A., J. Iqbal, F. Umbach, A.B. Scheiff, M.N. Munkonda, J. Sévigny, A.F. Knowles & C.E. Müller. (2008) Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5'-carboxamide. J. Med. Chem. 51(15): 4518-28. 
19. Iqbal, J., S.A. Lévesque, J. Sévigny & C.E. Müller. (2008) A highly sensitive CE-UV method with dynamic coating of silica-fused capillaries for the monitoring of nucleotide pyrophospha­tase/phosphodiesterase reactions. Electrophoresis 29: 3685-93. 
20. Ivanenkov, V.V., J. Sévigny & T.L. Kirley. (2008) Trafficking and intracellular ATPase activity of human ecto-nucleotidase NTPDase3, and the effect of ER-targeted NTPDase3 on protein folding. Biochemistry 47(35): 9184-97.  
21. Munkonda, M.N., J. Pelletier, V.V. Ivanenkov, M. Fausther, A. Tremblay, B. Künzli, T.L. Kirley & J. Sévigny. (2009) Characterization of a monoclonal antibody as the first specific inhibitor of human NTP diphosphohydrolase-3 - Partial characterization of the inhibitory epitope and potential applications. FEBS J. 276: 479-96. 
22. Eliahu, S.E., J. Camden, J. Lecka, G.A. Weisman, J. Sévigny, S. Gélinas & B. Fischer. (2009) Identification of hydrolytically stable and selective P2Y₁ receptor agonists. Eur. J. Med. Chem. 44(4): 1525-36. 
23. Ricatti, M.J., L.D. Alfie, E.G. Lavoie, J. Sévigny, P.J. Schwarzbaum & M.P. Faillace. (2009) Immunohistochemical localization of NTPDases1 and 2 in the neural retina of mouse and zebrafish. Synapse 63(4): 291-307.  
24. Martín-Satué, M., É.G. Lavoie, J. Pelletier, M. Fausther, E. Csizmadia, O. Guckelberger, S.C. Robson & J. Sévigny. (2009) Localization of plasma membrane bound NTPDases in the murine reproductive tract. Histochem. Cell. Biol. 131(5): 615-28. 
25. Kukulski, F., F. Ben Yebdri, J. Lecka, G. Kauffenstein, S.A. Lévesque, M. Martín-Satué & J. Sévigny. (2009) Extracellular ATP and P2 receptors are required for IL-8 to induce neutrophil migration. Cytokine 46(2): 166-70. 

Profile Details   

Last Updated: December 8, 2011.

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