Dr. Xavier Palomer
Biomedical Research Center Network in
Diabetes and Metabolic Diseases (CIBERDEM)
University of Barcelona, Spain
Email: xpalomer@ub.edu
Qualifications
2002 PhD at the Plant
Molecular Biology Department (IBMB-CSIC)
1995 Bachelor degree in Biology
at the University of Barcelona (UB)
Publications (Selected)
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Álvarez-Guardia D., Palomer X., Coll T., Davidson M.M., Chan T.O.,
Feldman A.M., Laguna J.C. and Vazquez-Carrera M. (2010). The p65 subunit of
NF-kappaB binds to PGC-1alpha, linking inflammation and metabolic disturbances
in cardiac cells. Cardiovasc Res 87, 449-458.
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Coll T., Barroso E., Álvarez-Guardia D., Serrano L., Salvadó L., Merlos
M., Palomer X. and Vázquez-Carrera M. (2010). The Role of Peroxisome
Proliferator-Activated Receptor b/d on the Inflammatory Basis of Metabolic
Disease. PPAR Res 2010, 368467.
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Coll T., Álvarez-Guardia D., Barroso E., Gomez-Foix A.M., Palomer X.,
Laguna J.C. and Vazquez-Carrera M. (2010). Activation of Peroxisome
Proliferator-Activated Receptor-{delta} by GW501516 Prevents Fatty Acid-Induced
Nuclear Factor-{kappa}B Activation and Insulin Resistance in Skeletal Muscle
Cells. Endocrinology 151, 1560-1569.
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Coll T., Palomer X., Blanco-Vaca F., Escola-Gil J.C., Sanchez R.M.,
Laguna J.C. and Vazquez-Carrera M. (2010). Cyclooxygenase 2 Inhibition
Exacerbates Palmitate-Induced Inflammation and Insulin Resistance in Skeletal
Muscle Cells. Endocrinology 151, 537-548.
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Álvarez-Guardia D., Palomer X., Coll T., Serrano L., Rodriguez-Calvo R.,
Davidson M.M., Merlos M., El Kochairi I., Michalik L., Wahli W. et al. (2011).
PPARbeta/delta activation blocks lipid-induced inflammatory pathways in mouse
heart and human cardiac cells. Biochim Biophys Acta 1811, 59-67.
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Barroso E., Rodriguez-Calvo R., Serrano-Marco L., Astudillo A.M.,
Balsinde J., Palomer X. and Vazquez-Carrera M. (2011). The PPAR{beta}/{delta}
Activator GW501516 Prevents the Down-Regulation of AMPK Caused by a High-Fat
Diet in Liver and Amplifies the PGC-1{alpha}-Lipin 1-PPAR{alpha} Pathway
Leading to Increased Fatty Acid Oxidation. Endocrinology 152, 1848-1859.
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Barroso E., Eyre E., Palomer X. and Vazquez-Carrera M. (2011). The
peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) agonist
GW501516 prevents TNF-alpha-induced NF-kappaB activation in human HaCaT cells
by reducing p65 acetylation through AMPK and SIRT1. Biochem Pharmacol 81,
534-543.
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Palomer X., Álvarez-Guardia D., Davidson M.M., Chan T.O., Feldman A.M.
and Vazquez-Carrera M. (2011). The Interplay between NF-kappaB and E2F1
Coordinately Regulates Inflammation and Metabolism in Human Cardiac Cells. PLoS
One 6, e19724.
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Serrano-Marco L., Rodriguez-Calvo R., El K., I, Palomer X., Michalik L.,
Wahli W. and Vazquez-Carrera M. (2011). Activation of Peroxisome
Proliferator-Activated Receptor-{beta}/-{delta} (PPAR-{beta}/-{delta})
Ameliorates Insulin Signaling and Reduces SOCS3 Levels by Inhibiting STAT3 in
Interleukin-6-Stimulated Adipocytes. Diabetes 60, 1990-1999.
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Mormeneo E., Jimenez-Mallebrera C., Palomer X., De N., V, Vazquez-Carrera
M., Orozco A., Nascimento A., Colomer J., Lerin C. and Gomez-Foix A.M. (2012).
PGC-1alpha Induces Mitochondrial and Myokine Transcriptional Programs and Lipid
Droplet and Glycogen Accumulation in Cultured Human Skeletal Muscle Cells. PLoS
One 7, e29985.
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Salvadó L., Serrano-Marco L., Barroso E., Palomer X. and Vázquez-Carrera
M. (2012). Targeting PPARb/d for the treatment of type 2 diabetes mellitus.
Expert Opin Ther Targets 16, 209-223.
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Serrano-Marco L., Barroso E., El K., I, Palomer X., Michalik L., Wahli W.
and Vazquez-Carrera M. (2012). The peroxisome proliferator-activated receptor
(PPAR) beta/delta agonist GW501516 inhibits IL-6-induced signal transducer and
activator of transcription 3 (STAT3) activation and insulin resistance in human
liver cells. Diabetologia 55, 743-751.
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Serrano-Marco L., Chacon M.R., Maymo-Masip E., Barroso E., Salvado L.,
Wabistch M., Garrido-Sanchez L., Tinahones F.J., Palomer X., Vendrell J. et al.
(2012). TNF-alpha inhibits PPARbeta/delta activity and SIRT1 expression through
NF-kappaB in human adipocytes. Biochim Biophys Acta 1821, 1177-1185.
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Barroso E., Valle J.D., Porquet D., Santos A.M., Salvado L.,
Rodriguez-Rodriguez R., Gutierrez P., nglada-Huguet M., Alberch J., Camins A.
et al. (2013). Tau hyperphosphorylation and increased bace1 and rage levels in
the cortex of PPARbeta/delta-null mice. Biochim Biophys Acta 1832, 1241-1248.
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Palomer X., Capdevila-Busquets E., Álvarez-Guardia D., Barroso E., Pallas
M., Camins A., Davidson M.M., Planavila A., Villarroya F. and Vazquez-Carrera
M. (2013). Resveratrol induces nuclear factor-kappaB activity in human cardiac
cells. Int J Cardiol 167, 2507-2516.
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Palomer X., Salvado L., Barroso E. and Vazquez-Carrera M. (2013). An
overview of the crosstalk between inflammatory processes and metabolic
dysregulation during diabetic cardiomyopathy. Int J Cardiol 168, 3160-3172.
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Salvadó L., Coll T., Gomez-Foix A.M., Salmeron E., Barroso E., Palomer X.
and Vazquez-Carrera M. (2013). Oleate prevents saturated-fatty-acid-induced ER
stress, inflammation and insulin resistance in skeletal muscle cells through an
AMPK-dependent mechanism. Diabetologia 56, 1372-1382.
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Palomer X., Capdevila-Busquets E., Garreta G., Davidson M.M. and
Vazquez-Carrera M. (2014). [PPARalpha attenuates palmitate-induced endoplasmic
reticulum stress in human cardiac cells by enhancing AMPK activity.]. Clin
Investig Arterioscler 26, 255-267.
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Palomer X., Capdevila-Busquets E., Botteri G., Salvado L., Barroso E.,
Davidson M.M., Michalik L., Wahli W. and Vazquez-Carrera M. (2014).
PPARbeta/delta attenuates palmitate-induced endoplasmic reticulum stress and
induces autophagic markers in human cardiac cells. Int J Cardiol 174, 110-118.
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Salvado L., Barroso E., Gomez-Foix A.M., Palomer X., Michalik L., Wahli
W. and Vazquez-Carrera M. (2014). PPARbeta/delta prevents endoplasmic reticulum
stress-associated inflammation and insulin resistance in skeletal muscle cells
through an AMPK-dependent mechanism. Diabetologia 57, 2126-2135.
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Torres M., Palomer X., Montserrat J.M., Vazquez-Carrera M. and Farre R.
(2014). Effect of ovariectomy on inflammation induced by intermittent hypoxia
in a mouse model of sleep apnea. Respir Physiol Neurobiol 202, 71-74.
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Barroso E., Rodriguez-Rodriguez R., Chacon M.R., Maymo-Masip E., Ferrer
L., Salvado L., Salmeron E., Wabistch M., Palomer X., Vendrell J. et al.
(2015). PPARbeta/delta ameliorates fructose-induced insulin resistance in
adipocytes by preventing Nrf2 activation. Biochim Biophys Acta 1852, 1049-1058.
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Chehaibi K., Cedo L., Metso J., Palomer X., Santos D., Quesada H., Naceur
S.M., Wahli W., Julve J., Vazquez-Carrera M. et al. (2015). PPAR-beta/delta
Activation Promotes Phospholipid Transfer Protein Expression. Biochem Pharmacol
94, 101-108.
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Massana L., Cabre A., Heras M., Amigó N., Correig X., Martínez-Hervás S.,
Real J.T., Ascaso J.F., Quesada H., Julve J. et al. (2015). Remarkable
quantitative and qualitative differences in HDL after niacin or fenofibrate
therapy in type 2 diabetic patients. Atherosclerosis 238, 213-219.
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Garcia-Ramirez M., Hernandez C., Palomer X., Vazquez-Carrera M. and Simo
R. (2015). Fenofibrate prevents the disruption of the outer blood retinal
barrier through downregulation of NF-kappaB activity. Acta Diabetol. In press.
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Salvadó L., Palomer X., Barroso E. and Vazquez-Carrera M. (2015).
Targeting endoplasmic reticulum stress in insulin resistance. Trends Endocrinol
Metab. In press.