Dr. Mahzuz Karim 

Norfolk and Norwich University Hospital, UK 

University of East Anglia, UK 

Email: mkarim@doctors.org.uk 

Qualifications 

2009 F.R.C.P. London 

2003 D.Phil., University of Oxford, UK 

1993 M.B, B.Chir., University of Cambridge School of Clinical Medicine, UK 

1990 B.A., University of Cambridge, UK 

Publications (Selected) 

1. Immunoregulatory T-cells can mediate specific unresponsiveness to alloantigens in vivo K.J. Wood, M. Hara, C.I. Kingsley, M. Karim, A.R. Bushell, P.J. Morris Transplanation Proceedings November 2001; 3 (7-8): 3829-3830 
2. CD25+CD4+ regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses C.I. Kingsley, M. Karim, A.R. Bushell, K.J. Wood Journal of Immunology February 1st 2002; 168 (3): 1080-1086 
3. The role of the graft in establishing tolerance M. Karim, U. Steger, A.R. Bushell, K.J. Wood Frontiers in Bioscience May 1st 2002; 7: e129-154 
4. Regulatory T cells in transplantation M. Karim, A.R. Bushell, K.J. Wood Current Opinion in Immunology October 2002; 14 (5): 584-591 
5. Renal failure due to scleroderma with thrombotic microangiopathy developing in a woman treated with carboplatin for ovarian cancer M. Karim, E. Vaux, D.R. Davies, P.D. Mason Clinical Nephrology November 2002; 58 (5): 384-388 
6. Transplantation tolerance K. Wood, I. Binet, M. Karim, W. Wong In: Horizons in Medicine Number 14, James Neuberger, editor. Royal College of Physicians of London, 2003, pages 275-279 
7. Pre-transplant blood transfusion without additional immunotherapy generates CD25+CD4+ regulatory T cells: A potential explanation for the blood transfusion effect A. Bushell, M. Karim, C.I. Kingsley, K.J. Wood Transplantation August 15th 2003; 76 (3): 449-455 
8. Rapidly progressive irreversible renal failure in patients with pancreatic insufficiency. P. Hill, M. Karim, D.R. Davies, I.S.D. Roberts, C.G. Winearls American Journal of Kidney Diseases October 2003; 42 (4): 842-845 
9. Regulatory cells in transplantation K.J. Wood, H. Ushigome, M. Karim, A. Bushell, S. Hori, S. Sakaguchi In: Generation and Effector Functions of Regulatory Lymphocytes, Gregory Bock and Jamie Goode, editors. John Wiley & Sons, 2003, pages 177-193 
10. Alloantigen-induced CD25+CD4+ regulatory T cells can develop in vivo from CD25-CD4+ precursors in a thymus-independent process M. Karim, C.I. Kingsley, A.R. Bushell, B.S. Sawitzki, K.J. Wood Journal of Immunology January 15th 2004; 172 (2): 923-928 
11. Proliferative glomerulonephritis associated with mantle cell lymphoma – natural history and effect of treatment in two casesM. Karim, P. Hill, G. Pillai, K. Gatter, D.R. Davies, C.G. Winearls Clinical Nephrology June 2004; 61 (6): 422-428 
12. A simple method to cure established tumors by inflammatory killing of normal cells. G.A. Daniels, L. Sanchez-Perez, R.M. Diaz, T. Kottke, J. Thompson, M. Lai, M. Gough, M. Karim, A. Bushell, H. Chong, A. Melcher, K. Harrington, R.G. Vile Nature Biotechnology September 2004; 22 (9): 1125-32 
13. CD25+CD4+ regulatory T cells generated by exposure to a model protein antigen prevent allograft rejection: antigen-specific re-activation in vivo is critical for bystander regulation M. Karim, G. Feng, K.J. Wood, A.R. Bushell Blood June 15th 2005; 105 (12): 4871-4877 
14. IFN-gamma production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo B. Sawitzki, C.I. Kingsley, V. Oliveira, M. Karim, M. Herber, K.J. Wood Journal of Experimental Medicine June 20th 2005; 201 (12): 1925-1935 
15. CD25+CD4+ regulatory T cells develop in mice not only during spontaneous acceptance of liver allografts but also after acute allograft rejection U. Steger, C.I. Kingsley, M. Karim, A.R. Bushell, K.J. Wood Transplantation November 15th 2006; 29 (9): 1202-1209 
16. Management of acute renal failure D.V. Hamilton, M. Karim Foundation Years Journal 2007; 1 (4): 189-191 
17. Exhaustive differentiation of alloreactive CD8+ T cells: critical for determination of graft acceptance or rejection U. Steger, C. Denecke, B. Sawitzki, M. Karim, N.D. Jones, K.J. Wood Transplantation May 15th 2008; 85 (9): 1339-1347 
18. Pulmonary fibrosis – an uncommon manifestation of anti-myeloperoxidase positive systemic vasculitis? A. Bhanji, M. Karim NDT Plus August 2010; 3 (4): 351-353 

Profile Details: 

https://www.researchgate.net/profile/Mahzuz-Karim 

Web of Science ID: H-3138-2019 

ORCID: 0000-0003-4515-4698