Dr. Moreno-Sánchez Rafael

Instituto Nacional de Cardiologia, Mexico

E-mail: morenosanchez@hotmail.com

Qualifications

1991-1993 Research Assistant Professor, Pathology Department, Hahnemann University, Philadelphia, PA

1986–1988 Visiting Fellow, Gerontology Research Center, National Institute on Aging, NIH, Baltimore, MD

Publications (Selected)

1. Marín-Hernández A, Gracia-Mora I, Ruiz-Ramírez L, Moreno-Sánchez R (2003) TOXIC EFFECTS OF COPPER-BASED ANTINEOPLASTIC DRUGS (CASIOPEINAS^Ò) ON MITOCHONDRIAL FUNCTIONS. Biochem. Pharmacol. 65, 1979-1989. (IF2010= 4.88; > 35 citations).
2. Da Silva WS, Gómez-Puyou A, Gómez-Puyou MT, Moreno-Sánchez R, De Felice FG, De Meis L, Oliveira MF, Galina A (2004) MITOCHONDRIAL BOUND HEXOKINASE ACTIVITY AS A PREVENTIVE ANTIOXIDANT DEFENSE: STEADY-STATE ADP FORMATION AS A REGULATORY MECHANISM OF MEMBRANE POTENTIAL AND REACTIVE OXYGEN SPECIES GENERATION IN MITOCHONDRIA. J. Biol. Chem. 279, 39846-39855. (IF2010= 5.32; > 60 citations).
3. Saavedra E, Encalada R, Pineda E, Jasso-Chávez R, Moreno-Sánchez R (2005) GLYCOLYSIS IN ENTAMOEBA HISTOLYTICA. BIOCHEMICAL CHARACTERIZATION OF RECOMBINANT GLYCOLYTIC ENZYMES AND FLUX CONTROL ANALYSIS. FEBS J. 272, 1767-1783 (IF2010= 3.12; > 30 citations).
4. Mendoza-Cózatl D, Loza-Tavera H, Hernández-Navarro A, Moreno-Sánchez R (2005) SULFUR ASSIMILATION AND GLUTATHIONE METABOLISM UNDER CADMIUM STRESS IN YEAST, PROTISTS AND PLANTS. FEMS Microbiol. Rev. 29, 653-671. (IF2010= 11.79; > 90 citations).
5. Mendoza-Cózatl D, Moreno-Sánchez R (2006) CONTROL OF GLUTATHIONE AND PHYTOCHELATIN SYNTHESIS UNDER CADMIUM STRESS.  PATHWAY MODELING FOR PLANTS. J. Theor. Biol. 238, 919-936. (IF2010= 2.45; > 35 citations).
6. Marín-Hernández A, Rodríguez-Enríquez S, Vital-González P, Flores-Rodríguez F, Macías-Silva M, Sosa-Garrocho M, Moreno-Sánchez R (2006) DETERMINING AND UNDERSTANDING THE CONTROL OF GLYCOLYSIS IN FAST-GROWTH TUMOR CELLS.  FLUX CONTROL BY AN OVER-EXPRESSED BUT STRONGLY PRODUCT-INHIBITED HEXOKINASE. FEBS J. 273, 1975-1988. (IF2010= 3.12; > 35 citations).
7. Rodríguez-Enríquez S, Vital-González PA, Flores-Rodríguez FL, Marín-Hernández A, Ruiz-Azuara L, Moreno-Sánchez R  (2006) CONTROL OF CELLULAR PROLIFERATION BY MODULATION OF OXIDATIVE PHOSPHORYLATION IN HUMAN AND RODENT FAST-GROWING TUMOR CELLS. Toxicol. Appl. Pharmacol. 215, 208-217. (IF2010= 3.99; > 30 citations).
8. Moreno-Sánchez R, Rodríguez-Enríquez S, Marín-Hernández A, Saavedra E (2007) ENERGY METABOLISM IN TUMOR CELLS. FEBS J. 274, 1393-1418. (IF2010= 3.12; > 125 citations).
9. Rodríguez-Enríquez S, Marín-Hernández A, Gallardo-Pérez JC, Carreño-Fuentes L, Moreno-Sánchez R (2009) TARGETING OF TUMOR ENERGY METABOLISM. Mol. Nutr. Food Res. 53, 29-48. (IF2010= 4.71; > 20 citations).
10. Dong LF, Freeman R, Liu J, Zobalova R, Marin-Hernandez A, Stantic M, Rohlena J, Rodriguez-Enriquez S, Valis K, Butcher B, Goodwin J, Brunk UT, Witting PK, Moreno-Sanchez R, Scheffler IE,  Ralph SJ, Neuzil J (2009) SUPRESSION OF TUMOUR GROWTH In Vivo BY THE MITOCAN α-TOS REQUIRES RESPIRATORY COMPLEX II. Clin. Cancer Res. 15, 1593-1600. (IF2010= 7.33; > 20 citations).
11. Marín-Hernández A, Gallardo-Pérez JC, Ralph SJ, Rodríguez-Enríquez S, Moreno-Sánchez R (2009) HIF-1a MODULATES ENERGY METABOLISM IN CANCER CELLS BY INDUCING OVER-EXPRESSION OF SPECIFIC GLYCOLYTIC ISOFORMS. MiniRev. Med. Chem. 9, 1084-1101. (IF2010= 2.62; > 30 citations).
12. Ralph SJ, Rodríguez-Enríquez S, Neuzil J, Saavedra E, Moreno-Sánchez R (2010) The causes of cancer revisited: hypoxia and glucose deprivation drive mitochondrial ROS induced oncogenic mutation and malignant transformation – implication for the selective targeting of cancer therapy.  Mol. Asp. Med. 31, 145-170. (IF2010= 10.55; > 20 citations).
13. Moreno-Sánchez S, Saavedra E, Rodríguez-Enríquez S, Gallardo-Pérez JC, Quezada H, Westerhoff HV (2010) METABOLIC CONTROL ANALYSIS INDICATES A CHANGE OF STRATEGY IN THE TREATMENT OF CANCER. Mitochondrion 10, 626-639.
14. Marín-Hernández A, Gallardo-Pérez JC, Rodríguez-Enríquez S, Encalada R, Moreno-Sánchez R, Saavedra E. (2011) Modeling Cancer Glycolysis. BBA-Bioenergetics 1807, 755-767.