Dr. Jonathan R. Keller
National Cancer Insititute-NIH, USA
Email: kellerjo@mail.nih.gov
Qualifications
1985 Ph.D., George Washington University, Washington, USA
1978 B.S., University of Maryland, College Park, Maryland, USA
Publications(Selected)
-
Du Y, Campbell JL, Nalbant D, Youn H, Bass
AC, Cobos E, Tsai S, Keller JR and Williams SC: Mapping gene
expression patterns during myeloid differentiation using the EML hematopoietic
progenitor cell line. Exp. Hematol. 30: 649-658, 2002.
-
Liu P, Keller JR, Ortiz M, Tessarollo L,
Rachel RA, Nakamura T, Jenkins NA and Copeland NG: Bcl11a is
essential for normal lymphoid development. Nat. Immunol. 4: 525-532, 2003.
-
McCauslin CS, Wine J, Cheng L, Klarmann
KD, Candotti F, Clausen PA, Spence SE and Keller JR: In vivo retroviral
gene transfer by direct intrafemoral injection results in correction of the
SCID phenotype in Jak3 knockout animals. Blood 102: 843-848, 2003.
-
Klarmann K, Ortiz M, Davis M and Keller
JR: Identification of in vitro growth conditions for c-Kit-negative
hematopoietic stem cells. Blood 102: 3120-3128, 2003.
-
Asefa B, Klarmann KD, Copeland NG, Gilbert
DJ, Jenkins NA and Keller JR: The interferon-inducible p200 family of proteins:
A perspective on their roles in cell cycle regulation and
differentiation. Blood Cells Mol. Dis. 32: 155-167, 2004.
-
Sharov A, Piao1 Y, Matoba R, Dudekula DB,
Qian Y, VanBuren V, Falco G, Martin PR, Stagg CA, Bassey UC, Wang Y, Carter MG,
Hamatani T, Aiba K, Akutsu H, Sharova L, Tanaka TS, Kimber WL, Yoshikawa T,
Jaradat SA, Pantano S, Nagaraja R, Boheler KR, Taub D, Hodes RJ, Longo DL,
Schlessinger D, Keller J, Klotz E, Kelsoe G, Umezawa A, Vescovi AL, Rossant A,
Kunath T, Hogan BM, Curci A, D’Urso M, Kelso J, Hide W, and Ko MS:
Transcriptome analysis of mouse stem cells and early embryos. PloS Bio. 1: 410-419, 2004.
-
Radosevic N, Winterstein D, Keller JR,
Neubauer H, Pfeffer K and Linnekin D: JAK2 contributes to the intrinsic
capacity of primary hematopoietic cells to respond to stem cell factor. Exp.
Hematol. 32: 149-156, 2004.
-
Jiang Q, Li WQ, Hofmeister RR, Young HA
Hodge DR Keller JR, Khaled AR and Durum SK: Distinct regions of the
interleukin-7 receptor regulate different Bcl-2 family members. Mol. Cell.
Biol. 24: 6501-6513, 2004.
-
Li WQ, Jiang Q, Khaled AR, Keller JR, and
Durum SK: Interleukin-7 inactivates the pro-apoptotic protein Bad promoting T
cell survival. J. Biol. Chem. 279: 299160-19166, 2004.
-
Dermott JM, Gooya JM, Asefa B, Weiler SR,
Smith M and Keller JR: Inhibition of growth by p205: A nuclear protein and
putative tumor suppressor expressed during myeloid cell differentiation. Stem
Cells 22: 832-848, 2004.
-
Heath V, Suh HC, Holman M, Renn K, Gooya
JM, Parkin S, Klarmann KD, Ortiz M, Johnson P, and Keller J: C/EBPα deficiency
results in hyperproliferation of hematopoietic progenitor cells and disrupts
macrophage development in vitro and in vivo. Blood 104: 1639-1647, 2004.
-
Jiang Q, Li WQ, Aiello FB, Klarmann KD,
Keller JR and Durum SK: Retroviral transduction of IL-7Rα into IL-7Rα-/- bone
marrow progenitors: correction of lymphoid deficiency and induction of
neutrophilia. Gene Ther. 12: 1761-1768, 2005.
-
Leeanansaksiri W, Wang H, Gooya JM, Renn
K, Abshari M, Tsai S and Keller JR: IL-3 induced inhibitor of DNA-binding
protein-1 in hematopoietic progenitor cells and promotes myeloid cell
development. J. Immunol. 174: 7014-7021, 2005.
-
Drutskaya MS, Ortiz M, Liepinsh DJ,
Kuprash DV, Nedospasov SA and Keller JR: Inhibitory effects of tumor necrosis
factor on hematopoiesis seen in vitro and translated to increased numbers of
both committed and multipotent progenitors in TNF-deficient mice. Exp. Hematol.
33: 1348-1356, 2005.
-
Liepinsh DJ, Grivennikov SI, Klarmann KD,
Lagarkova MA, Drutskaya MS, Lockett SJ, Tessarollo L, McAuliffe M, Keller JR,
Kuprash DV and Nedospasov SA: Novel lymphotoxin alpha (Ltά) knockout mice with
unperturbed tumor necrosis factor expression: reassessing the Ltά biological
functions. Mol. Cell. Biol. 26: 4214-4225, 2006.
-
Asefa B, Dermott JM, Kaldis P, Stefanisko
K, Garfinkel DJ and Keller JR: p205 a potential tumor suppressor, inhibits cell
proliferation via multiple pathways of cell cycle regulation. FEBS Lett. 580:
1205-1214, 2006.
-
Suh HC, Gooya J, Renn K, Friedman AD,
Johnson PF and Keller JR: C/EBPα determines hematopoietic cell fate in
multipotential progenitor cells by inhibiting erythroid differentiation and
inducing myeloid differentiation. Blood 107: 4308 – 4316, 2006.
-
Berthet C, Klarmann KD, Hilton MB, Suh HC,
Keller JR, Kiyokawa H, Kaldis P: Combined Loss of Cdk2 and Cdk4 Results in
Embryonic Lethality and Rb Hypophosphorylation. Dev. Cell 10: 563-573, 2006.
-
Aiello FB, Keller JR, Klarmann KD, Dranoff
G, Mazzucchelli R, Durum SK: IL-7 Induces Myelopoiesis and Erythropoiesis. J.
Immunology 78: 1553-1563, 2007.
-
Jiang Q, Huang J, Li W, Cavinato T, Keller
JR, and Durum SK: Role of the intracellular domain of IL-7 receptor in T cell
development. J. Immunology 178: 228-232, 2007.