Prof. Giulio Maria Pasinetti

Mount Sinai School of Medicine, USA

E-mail: giulio.Pasinetti@mssm.edu

Qualifications

Publications (Selected)

1. Yang, E. J., Frolinger, T., Iqbal, U. H., Murrough, J., & Pasinetti, G. M. (2023). The Bioactive Dietary Polyphenol Preparation Alleviates Depression and Anxiety-Like Behaviors by Modulating the Regional Heterogeneity of Microglia Morphology. Molecular Nutrition and Food Research, 67(21), Article 2300156. https://doi.org/10.1002/mnfr.202300156
2. Yang, E. J., Al Rahim, M., Griggs, E., Iban-Arias, R., & Pasinetti, G. M. (2023). Transient anxiety-and depression-like behaviors are linked to the depletion of Foxp3-expressing cells via inflammasome in the brain. PNAS Nexus, 2(8), Article pgad251. https://doi.org/10.1093/pnasnexus/pgad251
3. Pasinetti, G. M., Singh, R., Westfall, S., Herman, F., Faith, J., & Ho, L. (2022). The Role of the Gut Microbiota in the Metabolism of Polyphenols as Characterized by Gnotobiotic Mice. In G. M. Pasinetti (Ed.), Handbook of Microbiome and Gut-Brain-Axis in Alzheimer’s disease (pp. 203-215). (Advances in Alzheimer's Disease; Vol. 9). IOS Press BV. https://doi.org/10.3233/AIAD220014
4. Smith, C., Trageser, K. J., Wu, H., Herman, F. J., Iqbal, U. H., Sebastian-Valverde, M., Frolinger, T., Zeng, E., & Pasinetti, G. M. (2021). Anxiolytic effects of NLRP3 inflammasome inhibition in a model of chronic sleep deprivation. Translational Psychiatry, 11(1), Article 52. https://doi.org/10.1038/s41398-020-01189-3
5. Sebastian-Valverde, M., Wu, H., Rahim, M. A., Sanchez, R., Kumar, K., De Vita, R. J., & Pasinetti, G. M. (2021). Discovery and characterization of small-molecule inhibitors of NLRP3 and NLRC4 inflammasomes. Journal of Biological Chemistry, 296, Article A99. https://doi.org/10.1016/j.jbc.2021.100597
6. Ono, K., Tsuji, M., Yamasaki, T. R., & Pasinetti, G. M. (2020). Anti-aggregation effects of phenolic compounds on α-synuclein. Molecules, 25(10), Article 2444. https://doi.org/10.3390/MOLECULES25102444
7. Docampo-Palacios, M. L., Alvarez-Hernández, A., Adiji, O., Gamiotea-Turro, D., Valerino-Diaz, A. B., Viegas, L. P., Ndukwe, I. E., De Fátima, Â., Heiss, C., Azadi, P., Pasinetti, G. M., & Dixon, R. A. (2020). Glucuronidation of Methylated Quercetin Derivatives: Chemical and Biochemical Approaches. Journal of Agricultural and Food Chemistry, 68(50), 14790-14807. https://doi.org/10.1021/acs.jafc.0c04500
8. Naughton, S. X., Raval, U., & Pasinetti, G. M. (2020). Potential Novel Role of COVID-19 in Alzheimer's Disease and Preventative Mitigation Strategies. Journal of Alzheimer's Disease, 76(1), 21-25. https://doi.org/10.3233/JAD-200537
9. Iqbal, U. H., Zeng, E., & Pasinetti, G. M. (2020). The use of antimicrobial and antiviral drugs in alzheimer’s disease. International Journal of Molecular Sciences, 21(14), 1-19. Article 4920. https://doi.org/10.3390/ijms21144920
10. Ho, L., Zhao, D., Ono, K., Ruan, K., Mogno, I., Tsuji, M., Carry, E., Brathwaite, J., Sims, S., Frolinger, T., Westfall, S., Mazzola, P., Wu, Q., Hao, K., Lloyd, T. E., Simon, J. E., Faith, J., & Pasinetti, G. M. (2019). Heterogeneity in gut microbiota drive polyphenol metabolism that influences α-synuclein misfolding and toxicity. Journal of Nutritional Biochemistry, 64, 170-181. https://doi.org/10.1016/j.jnutbio.2018.10.019
11. Wang, J., Hodes, G. E., Zhang, H., Zhang, S., Zhao, W., Golden, S. A., Bi, W., Menard, C., Kana, V., Leboeuf, M., Xie, M., Bregman, D., Pfau, M. L., Flanigan, M. E., Esteban-Fernández, A., Yemul, S., Sharma, A., Ho, L., Dixon, R., ... Pasinetti, G. M. (2018). Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice. Nature Communications, 9(1), Article 477. https://doi.org/10.1038/s41467-017-02794-5
12. Chen, T. Y., Ferruzzi, M. G., Wu, Q. L., Simon, J. E., Talcott, S. T., Wang, J., Ho, L., Todd, G., Cooper, B., Pasinetti, G. M., & Janle, E. M. (2017). Influence of diabetes on plasma pharmacokinetics and brain bioavailability of grape polyphenols and their phase II metabolites in the Zucker diabetic fatty rat. Molecular Nutrition and Food Research, 61(10), Article 1700111. https://doi.org/10.1002/mnfr.201700111
13. Wang, J., Bi, W., Zhao, W., Varghese, M., Koch, R. J., Walker, R. H., Chandraratna, R. A., Sanders, M. E., Janesick, A., Blumberg, B., Ward, L., Ho, L., & Pasinetti, G. M. (2016). Selective brain penetrable Nurr1 transactivator for treating Parkinson's disease. Oncotarget, 7(7), 7469-7479. https://doi.org/10.18632/oncotarget.7191
14. Wang, J., Freire, D., Knable, L., Zhao, W., Gong, B., Mazzola, P., Ho, L., Levine, S., & Pasinetti, G. M. (2015). Childhood and adolescent obesity and long-term cognitive consequences during aging. Journal of Comparative Neurology, 523(5), 757-768. https://doi.org/10.1002/cne.23708
15. Fargali, S., Garcia, A. L., Sadahiro, M., Jiang, C., Janssen, W. G., Lin, W. J., Cogliani, V., Elste, A., Mortillo, S., Cero, C., Veitenheimer, B., Graiani, G., Pasinetti, G. M., Mahata, S. K., Osborn, J. W., Huntley, G. W., Phillips, G. R., Benson, D. L., Bartolomucci, A., & Salton, S. R. (2014). The granin VGF promotes genesis of secretory vesicles, and regulates circulating catecholamine levels and blood pressure. FASEB Journal, 28(5), 2120-2133. https://doi.org/10.1096/fj.13-239509
    
16. Ho L, Chen LH, Wang J, Zhao W, Talcott ST, Ono K, Teplow D, Humala N, Cheng A, Percival SS, Ferruzzi M, Janle E, Dickstein DL,Pasinetti GM. Heterogeneity in red wine polyphenolic contents differentially influences Alzheimer’s disease-type neurophathology and cognitive deterioration. J Alzheimers Dis. 16(1):59-72(2009)
17. Ho L, Yemul S, Wang J, Pasinetti GM. Grape seed polyphenolic extract (GSE) as a novel therapeutic agent in tauopathies. J Alzheimers Dis.16(2):433-9(2009).
18. Zhao W, Wang J, Ho L, Teplow D, PasinettiGM. Identification of antihypertensive drugs which inhibit amyloid-β protein oligomerization. J Alzheimers Dis. 16(1):49-57 (2009)
19. Qin W, Ho L, Wang J, Peskind E, Pasinetti GM. S100A7, a novel Alzheimer’s disease biomarker with anti-amyloidogenic activities acts via selective promotion of ADAM-10.  PLoS One4(1):e4183(2009).
20. Qin W, Haroutunian V, Katsel P, Cardozo C, Ho L, Buxbaum JD, PasinettiGM. PGC-1α expression decreases in the brain of Alzheimer’s disease as a function of progression of clinical dementia. Arch Neurol 66(3): 352-61 (2009).
21. Ferruzzi MG, Lobo JK, Janle EM, Cooper B, Simon JE, Wu QL, Welch C, Ho L, Weaver C, Pasinetti GM.  Brain bioavailability of gallic acid and catechins is improved by repeated dosing in rats: Implications for treatment in Alzheimer’s disease.J Alzheimers Dis.18(1):113-24 (2009).
22. Diaz-Ruiz C, Wang J, Ksiezak-Reding H, Ho L, Qian X, Humala N, Thomas S, Martinez-Martin P, Pasinetti GM. Role of hypertension in aggravating Aβ neuropathology of AD type and tau mediated motor impairment. Cardiovasc Psychiatry Neurol2009:107286(2009).
23. Pedrini S, Thomas C, Brautigam H, Schmeidler J, Ho L, Fraser P, Westaway D, Hyslop PS, Martins RN, Buxbaum JD, Pasinetti GM, Dickstein DL, Hof PR, Ehrlich ME, Gandy S.  Dietary composition modulates brain mass and solubilizable Aβ levels in a mouse model of aggressive Alzheimer’s amyloid pathology.  Mol Neurodegener 4:40 (2009).
24. Ho L, Fivecoat H, Wang J, Pasinetti GM. Alzheimer’s disease biomarker discovery in symptomatic and asymptomatic patients: Experimental approaches and future clinical applications. Exp Gerontol45(1):15-22(2010).
25. Wang J, Fivecoat H, Ho L, Pan Y, Pasinetti GM. The role of SIRT1: At the crossroad between promotion of longevity and protection against Alzheimer’s disease neuropathology. Biochim Biophys Acta1804(8):1690-4(2010).
26. Fivecoat HC, Pasinetti GM.  Illuminating polyphenols in neurodgeneration.  Frontiers Neuroscience http://www.frontiersin.org/llluminatingpolyphenols/ (2010)
27. Wang J, Pfleger C, Friedman L, Vittorino R, Zhao W, Qian X, Conley L, Ho L, Pasinetti GM. Development of grape seed polyphenolic extract as potential therapeutic agent in Huntington’s disease. Translational Neuroscience1(2):95-100(2010)
28. Arrieta-Cruz I, Wang J, Pavlides C, Pasinetti GM. Carvedilol reestablishes long-term potentiation in a model of Alzheimer’s disease.  J Alzheimer’s Dis 21(2); 649-654 (2010)
29. Bartolomucci A, Pasinetti GM, Salton SRJ. Granins as disease-biomarkers: translational potential for psychiatric and neurological disorders.  Neuroscience 170(1) 289-297 (2010).
30. Dixon RA, Pasinetti GM. Flavonoids and isoflavonoids: from plant biology to agriculture and neuroscience. Plant Physiology, 154(2) 453-457 (2010).
31. Gong B, Chen F, Pan Y, Arrieta-Cruz I, Yoshida, Y, Haroutunian, V, Pasinetti GM.SCFFbx2-E3 ligase mediated degradation of BACE1 attenuates Alzheimer’s disease amyloidosis and improves synapticfunction. Aging Cell 9(6) 10-18-1031(2010).
32. Pasinetti GM, Fivecoat H, Ho L. Personalized medicine in traumatic brain injury. Psychiatric Clinics of North America 33(4) 905-913 (2010).
33. Pasinetti GM, Ksiezak-Reding H, Ho L, Santa-Maria Perez I, Wang J. Development of a grape seed polyphenolic extract with anti-oligomeric activity as a novel treatment in progressive supranuclear palsy and other tauopathies. J Neurochem 114(6)1557-1568 (2010).
34. Wang J, Santa-Maria I, Ho L, Ksiezak-Reding, Ono K, Teplow DB, Pasinetti GM. Grape derived polyphenols attenuate tau neuropathology in a mouse model of Alzheimer’s disease. J Alzheimers Dis 22(2) 653-661(2010).
35. Sharma V, Zhang C, Pasinetti GM, Dixon RA. Fractionation of grape seed proanthocyanidins for bioactivity assessment. Recent Advances in Phytochemistry(2010)
36. Wang J, Ono K, Dickstein D, Arrieta-Cruz I, Zhao W, Qian X, Lamparello A, Subnani R, Ferruzzi M, Pavlides C, Ho L, Hof P, Teplow DB, Pasinetti GM.  Carvedilol as a potential novel agent for the treatment of Alzheimer’s disease.  Neurobiol Aging (2010)
37. Arrieta-Cruz I, Pavlides C, Pasinetti GM. Deep brain stimulation in the midline thalamic region facilitates short-term memory in a mouse model of Alzheimer's disease.  Translational Neurosci (2010).
38. Pasinetti GM, Ho L. The role of grape seed polyphenols in Alzheimer’s disease neuropathology. Nutrition and Dietary Supplements (2010).
39. Ho L, Pasinetti GM.  Polyphenolic compounds with anti-oligomeric bioactivity for treating neurodegenerative disorders involving protein misfoldings.  Expert Review of Proteomics (2010).
40. Pfleger CM, Wang J, Friedman L, Vittorino R, Conley LM, Ho L, Fivecoat HC, Pasinetti GM.Grape seed polyphenolic extract improves the eye phenotype in aDrosphilamodel of tauopathy. Int J Alzheimers Dis (2010)
41. Wang J, Pfleger CM, Friedman L, Vittorino R, Zhao W, Qian X, Conley LM, Ho L, Pasinetti GM. Potential Application of Grape Dervied Polyphenols in Huntington’s Disease. Translational Neurosci (2010)

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