Biography

Dr. Anshu Agrawal

Department of Medicine

University of California, USA


Email: aagrawal@uci.edu


Qualifications

1994 Ph.D., Biochemistry, Lucknow University, India

1988 M.Sc., Biochemistry, Lucknow University, India

1986 B.Sc., Chemistry, Botany, Zoology, Lucknow University, India


Publications (selected)

  1. Agrawal, S., Tran, M. T., Jennings, T. S. K., Soliman, M. M. H., Heo, S., Sasson, B., ... & Agrawal, A. (2024). Changes in the innate immune response to SARS-CoV-2 with advancing age in humans. Immunity & Ageing, 21(1), 21.
  2. Gupta, S., & Agrawal, A. (2023). Dendritic cells in inborn errors of immunity. Frontiers in Immunology, 14, 1080129.
  3. Srivastava, R., Agrawal, A., Vahed, H., & BenMohamed, L. (2023). Age-Related Impairment of Innate and Adaptive Immune Responses Exacerbate Respiratory Viral Infection in Older Mice.
  4. Agrawal, A., Agrawal, S., & Monteiro, C. (2022). Differential Response of Dendritic Cells and Macrophages to Signals from Airway Epithelial Cells in Humans: Changes with Age. The Journal of Immunology, 208(Supplement_1), 48-02.
  5. Agrawal, S., Baulch, J. E., Madan, S., Salah, S., Cheeks, S. N., Krattli Jr, R. P., ... & Agrawal, A. (2022). Impact of IL-21-associated peripheral and brain crosstalk on the Alzheimer’s disease neuropathology. Cellular and Molecular Life Sciences, 79(6), 331.
  6. Agrawal, S., Salazar, J., Tran, T. M., & Agrawal, A. (2021). Sex-related differences in innate and adaptive immune responses to SARS-CoV-2. Frontiers in Immunology, 12, 739757.
  7. Baulch, J. E., Acharya, M. M., Agrawal, S., Apodaca, L. A., Monteiro, C., & Agrawal, A. (2020). Immune and inflammatory determinants underlying Alzheimer’s disease pathology. Journal of neuroimmune pharmacology, 15, 852-862.
  8. Nguyen, H. M. H., Torres, J. A., Agrawal, S., & Agrawal, A. (2020). Nicotine Impairs the Response of Lung Epithelial Cells to IL‐22. Mediators of inflammation, 2020(1), 6705428.
  9. Agrawal, S., Abud, E. M., Snigdha, S., & Agrawal, A. (2018). IgM response against amyloid-beta in aging: a potential peripheral protective mechanism. Alzheimer's Research & Therapy, 10, 1-11.
  10. Agrawal, A., Agrawal, S., & Gupta, S. (2017). Role of dendritic cells in inflammation and loss of tolerance in the elderly. Frontiers in immunology, 8, 896.
  11. Agrawal, S., Ganguly, S., Tran, A., Sundaram, P., & Agrawal, A. (2016). Retinoic acid treated human dendritic cells induce T regulatory cells via the expression of CD141 and GARP which is impaired with age. Aging (Albany NY), 8(6), 1223.
  12. Agrawal, S., Agrawal, A., & Said, H. M. (2016). Biotin deficiency enhances the inflammatory response of human dendritic cells. American Journal of Physiology-Cell Physiology, 311(3), C386-C391.
  13. Sridharan A, Esposo M, Kaushal K, Tay J, Osann K, Agrawal S, Gupta S,Agrawal A.Age-associated impaired plasmacytoid dendritic cell functions lead to decreased CD4 and CD8 T cell immunity.AGE. 2010. (in press).DOI: 10.1007/s11357-010-9191-3.
  14. Agrawal S, Gupta S andAgrawal A.Human dendritic cells activated via Dectin-1 are efficient at priming Th17, cytotoxic CD8 T and B cell responses.PLoS One. 2010 Oct 18;5(10):e13418.
  15. Agrawal Aand Gupta S. Impact of aging on dendritic cell functions in humans. Ageing Research Reviews. 2010. Accepted.
  16. Agrawal A,Tay J, Yang GE, Agrawal S, Gupta S. Age-associated epigenetic modifications in human DNA increases its immunogenicity.Aging.2010.Jan10. Epub ahead of print. NIHMSID-176388.
  17. Carlson ME, Conboy MJ, Hsu M, Barchas L, Jeong J, Agrawal A, Mikels AJ, Agrawal S, Schaffer DV, Conboy IM. Relative roles of TGF-beta1 and Wnt in the systemic regulation and aging of satellite cell responses.Aging Cell.2009. 8(6):676-89.
  18. Gu B, Sun P, Yuan Y, , Moraes RC, Li A, Teng A,Agrawal A, Rhéaume C, Bilanchone V, Veltmaat JM, X.*Takemaru KI, Millar S, Lee EYHP, Lewis MT, Li B and DaiPygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation.Journal of Cell biology. 2009. 185: 811-826.
  19. Agrawal A,Tay J, Ton S, Agrawal S, Gupta S.Increased Reactivity of Dendritic Cells from Aged Subjects to Self Antigen, the Human DNA.J Immunol. 2009. 182: 1138-1145.
  20. Agrawal S,Gupta S,Agrawal A.  Vaccinia Virus Proteins Activate Human Dendritic Cells to Induce T Cell Responses in vitro.Vaccine.2009. 27:88-92.
  21. Agrawal A.How Aging impacts innate immunity. New Research on Innate Immunity.2008. (Nova Publishers).63-72.
  22. Agrawal A,Lourenco EV, Gupta S, La Cava A. Gender-based differences in leptinemia in healthy aging, non-obese individuals associated with increased marker of oxidative stress.Int J Clin Exp Med.2008.1 : 305-309.
  23. Agrawal A,Agrawal S, Tay, J, Gupta S. Biology of Dendritic Cells in Aging.J Clin. Immunol. 2008. 28: 14-20.
  24. Agrawal A, Agrawal S, Cao J, Su H, Osann K, Gupta S. Altered innate immune functioning of dendritic cells in aging humans : Role of PI3Kinase signaling pathway.J Immunol. 2007.178:6912-6922.
  25. Agrawal A, Kaushal P, Agrawal S, Gollapudi S, Gupta S. Thimerosal affects human dendritic cell functions promoting a TH2 response.J Leukocyte Biology. 2007. 81: 474-483.
  26. Agrawal A, Agrawal S, Gupta, S. Dendritic cells in human aging.Experimental Gerontology. 2006. 42(5): 421-426.
  27. Agrawal A, Dillon S, Denning TL, and Pulendran B. ERK1-/- mice exhibit Th1 cell polarization and increased susceptibility to Experimental Autoimmune Encephalomyelitis.J Immunol. 2006. 176: 5788 - 5796.
  28. Gupta S, Agrawal A, Agrawal S, Su H and Gollapudi S. A paradox of immunodeficiency and inflammation in aging: Lessons learned from apoptosis.Immunity & Ageing. 2006. 3:5.
  29. Nair M, Teng A, Bilanchone V,Agrawal A, Li B, and Dai X.Ovol1 regulates the growth arrest of embryonic epidermal progenitor cells and represses c-Myc transcription. Journal of Cell biology.2006. 173: 253-264.
  30. Sharma, SK., Deba, F., Bhattachrya, S., Agrawal, A., Owais, M. Escheriosome entrapped soluble blood stage antigens impart protective immunity against a multi-drug resistant isolate of Plasmodium yoelii nigeriensis in BALB/c mice.Vaccine. 2006. 7:948-956.
  31. Pulendran B, Agrawal A, Dillon S , Agrawal S. Dendritic cells: Target of Immune Modulation by Microbes and Immunologist.Vaccine Adjuvants -Immunological and Clinical Principles.2005.25-38.(Humana Press).
  32. Agrawal A and Pulendran B. Anthrax lethal toxin: a weapon of multisystem destruction.Cell Mol Life Sci. 2004 61(22):2859-65.


Profile Details

https://faculty.uci.edu/profile/?facultyId=5170
https://scholar.google.com/citations?user=LBHKTrUAAAAJ&hl=en
https://loop.frontiersin.org/people/154187

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