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Biography

Prof. Periasamy Selvaraj

Department of Pathology

Emory University School of Medicine, USA


Email: pselvar@emory.edu


Qualifications

1984 Ph.D., Biochemistry, Christian Medical College, India

1977 M.Sc., Biochemistry, University of Madras, India

1975 B.Sc., Chemistry, University of Madras, India


Publications (selected)

  1. SELVARAJ P, Balasubramanian KA, and Hill, PG.Isolation of gamma-glutamyltransferase fromhuman primary hepatoma and comparison ofits kinetic and catalytic properties with the enzyme from normal and fetalliver. Enzyme. 1981; 26: 57-63.
  2. SELVARAJ P, Balasubramanian, KA. Localization of gamma- glutamyl transferase on polyacrylamide gels usingL- gamma- glutamyl-p-nitroanilide as substrate. Clin. Chim. Acta. 1982; 121:291-300
  3. SELVARAJ P, Balasubramanian KA. Soluble forms of gamma - glutamyltransferasein human adult liver, fetal liver and primary hepatoma compared. Clin. Chem.1983; 29: 90-95.
  4. SELVARAJ P, Balasubramanian KA. Comparison of electrophoretic andimmunological properties of gamma- glutamyltransferase from human adult liver,fetal liver and primary hepatoma. Enzyme. 1983; 30: 21-28.
  5. SELVARAJ P, Rolston, DDK. and Balasubramanian, KA. Separation of hydrophobic and hydrophilicforms of gamma- glutamyltransferase from human serum by hydrophobicchromatography on phenyl-sepharose CL-4B: studies on normal sera and sera ofpatients with liver disease. Clin. Chim.Acta. 1984; 138: 141-149.
  6. SELVARAJ P., K.A.Balasubramanian. Formation of Co2+- Triscomplex and its interference in kinetic assay of enzymes: with special referenceto apparent inhibition of gamma-glutamyltransferase. Ind. J. Biochem. Biophys. 1984; 21:389-391.
  7. SELVARAJ P. Studies ongamma-glutamyl transferase from human fetal liver, normal adult liver andprimary hepatoma. Ph.D. Thesis,University of Madras, May 1984.
  8. SELVARAJ P, Balasubramanian KA. Comparative structural and lectin binding studies ongamma-glutamyltransferase from human adult liver, fetal liver and primaryhepatoma. Eur. J. Biochem. 1985; 153: 485-490.
  9. SELVARAJ P, Plunkett ML, Dustin ML, Sanders ME, Shaw, S and Springer,TA. The T-lymphocyte glycoprotein CD2binds the cell surface ligand LFA-3. Nature 1987; 326: 400-403.
  10. Plunkett M.L., M.E. Sanders, P. SELVARAJ, M.L. Dustin, S. Shaw andT.A. Springer. Rosetting of activated T-lymphocytes with autologouserythrocytes: Definition of the receptor and ligand molecules as CD2 andlymphocyte function associated antigen-3 (LFA-3). J. Exp. Med. 1987; 165:664-676.
  11. SELVARAJ P Dustin, R. Mitnacht, T. Hunig, T.A. Springer and M.L.Plunkett. Rosetting of humanT-lymphocytes with sheep and human erythrocytes: Comparison of human and sheep ligands bindingusing purified E receptor. J. Immunol. 1987; 138:2690-2695.
  12. SELVARAJ P, Dustin ML, Silber R, Low MG, and Springer, TA. Deficiency of lymphocyte function associatedantigen- 3 (LFA-3) in Paroxysmal Nocturnal Hemoglobinuria: Functional correlatesand evidence for a phosphatidylinositol membrane anchor. J. Exp. Med. 1987; 166:1011-1025.
  13. Dustin ML, SELVARAJ P, Mattaliano R, and Springer, TA. Anchoring mechanisms for LFA-3 cell adhesionglycoprotein at membrane surface. Nature1987; 329: 846-848
  14. Hollander N, SELVARAJ P, and Springer, TA. Biosynthesis and functionof LFA-3 in human mutant cells deficient in phosphatidylinositol -anchoredproteins. J. Immunol. 1988; 141: 4283-4290
  15. KuchrooVJ, Steele JK, Billings P, SELVARAJ P, and Dorf ME. Antigenbinding CD3 bearing suppressor T cell hybridoma: I. Expression of CD3 associatedantigen binding receptors on suppressor T cells. Proc. Natl. Acad. Sci. (USA) 1988; 85:9209-9213
  16. Carpen O, SELVARAJ P, Hibbs ML, and Springer TA. The ability of NK cell and granulocyte formsof CD16 to trigger cytolytic function.Natural Killer cells: Biology and Clinical Application. 1990; pp50-54 (Proc. of 6th Int. Natural KillerCell Workshop Goslar 1989. Ed: R.E. Schmidt, Kargerpublications).
  17. Kuchroo VK, Steele JK, O' Hara Jr RM, Jayaraman S, SELVARAJ P,Greenfield E, Kubo RT, and Dorf, ME. Relationships between antigen specific helper and inducer suppressor Tcell hybridomas. J. Immunol. 1990; 145:438-448
  18. McHugh, R., L. Cobrn, and P. SELVARAJ. Differences in surface expression of adhesionmolecules on cytotoxic and non-cytotoxic NK 3.3 cells. Leukocyte Typing V :1574-1576. (Oxford Univ. Press 1993).
  19. Wang, Y-C., L. Zhu, R. McHugh, K. W. Sell and P. SELVARAJ. Heatstable antigen/CD24 provides a costimulatory signal for the tumor specific Tcell proliferation and cytotoxicity in mice. Eur. J. Immunol. 1995; 25:1163-1167.
  20. Nagarajan, S., M. Anderson S. N. Ahmed, K. W. Sell.and P.SELVARAJ. Purification and optimizationof functional reconstitution on the surface of leukemic cell lines ofGPI-anchored receptor III.gFcJ. Immunol. Methods 1995.184: 241-251.

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