Biography

Prof. Periasamy Selvaraj

Department of Pathology

Emory University School of Medicine, USA


Email: pselvar@emory.edu


Qualifications

1984 Ph.D., Biochemistry, Christian Medical College, India

1977 M.Sc., Biochemistry, University of Madras, India

1975 B.Sc., Chemistry, University of Madras, India


Publications (selected)

  1. Monterroza, L., Parrilla, M. M., Samaranayake, S. G., Rivera-Rodriguez, D. E., Yoon, S. B., Bommireddy, R., ... & Tirouvanziam, R. (2024). Tumor-intrinsic enhancer of zeste homolog 2 controls immune cell infiltration, tumor growth, and lung metastasis in a triple-negative breast cancer model. International Journal of Molecular Sciences, 25(10), 5392.
  2. Sabit, H., Arneth, B., Abdel-Ghany, S., Madyan, E. F., Ghaleb, A. H., Selvaraj, P., ... & Elhashash, A. (2024). Beyond cancer cells: How the tumor microenvironment drives cancer progression. Cells, 13(19), 1666.
  3. Park, B. R., Bommireddy, R., Chung, D. H., Kim, K. H., Subbiah, J., Jung, Y. J., ... & Kang, S. M. (2023). Hemagglutinin virus-like particles incorporated with membrane-bound cytokine adjuvants provide protection against homologous and heterologous influenza virus challenge in aged mice. Immunity & Ageing, 20(1), 20.
  4. Zhang, H., Passang, T., Ravindranathan, S., Bommireddy, R., Jajja, M. R., Yang, L., ... & Waller, E. K. (2023). The magic of small-molecule drugs during ex vivo expansion in adoptive cell therapy. Frontiers in immunology, 14, 1154566.
  5. Bommireddy, R., Stone, S., Bhatnagar, N., Kumari, P., Munoz, L. E., Oh, J., ... & Selvaraj, P. (2022). Influenza virus-like particle-based hybrid vaccine containing RBD induces immunity against influenza and SARS-CoV-2 viruses. Vaccines, 10(6), 944.
  6. Munoz, L. E., Huang, L., Bommireddy, R., Sharma, R., Monterroza, L., Guin, R. N., ... & Selvaraj, P. (2021). Metformin reduces PD-L1 on tumor cells and enhances the anti-tumor immune response generated by vaccine immunotherapy. Journal for immunotherapy of cancer, 9(11), e002614.
  7. Huang, L., Bommireddy, R., Munoz, L. E., Guin, R. N., Wei, C., Ruggieri, A., ... & Selvaraj, P. (2021). Expression of tdTomato and luciferase in a murine lung cancer alters the growth and immune microenvironment of the tumor. PLoS One, 16(8), e0254125.
  8. Pack, C. D., Bommireddy, R., Munoz, L. E., Patel, J. M., Bozeman, E. N., Dey, P., ... & Selvaraj, P. (2020). Tumor membrane-based vaccine immunotherapy in combination with anti-CTLA-4 antibody confers protection against immune checkpoint resistant murine triple-negative breast cancer. Human Vaccines & Immunotherapeutics, 16(12), 3184-3193.
  9. Berry, J. T., Muñoz, L. E., Stewart, R. M. R., Selvaraj, P., & Mainou, B. A. (2020). Doxorubicin conjugation to reovirus improves oncolytic efficacy in triple-negative breast cancer. Molecular Therapy-Oncolytics, 18, 556-572.
  10. Bommireddy, R., Munoz, L. E., Kumari, A., Huang, L., Fan, Y., Monterroza, L., ... & Selvaraj, P. (2020). Tumor membrane vesicle vaccine augments the efficacy of anti-PD1 antibody in immune checkpoint inhibitor-resistant squamous cell carcinoma models of head and neck cancer. Vaccines, 8(2), 182.
  11. Selvaraj, S., Mondragon-Gonzalez, R., Xu, B., Magli, A., Kim, H., Lainé, J., ... & Perlingeiro, R. C. (2019). Screening identifies small molecules that enhance the maturation of human pluripotent stem cell-derived myotubes. Elife, 8, e47970.
  12. Munoz, L. E., Bommireddy, R., Huang, H., Kim, J., & Selvaraj, P. (2019). Abstract LB-203: Metformin enhances the efficacy of tumor membrane vesicle (TMV)-based vaccine immunotherapy in a murine model of breast. Cancer Research, 79(13_Supplement), LB-203.
  13. Bommireddy, R., Menon, A. P., Munoz, L. E., Huang, L., Kim, J., Kumar, J., ... & Selvaraj, P. (2018). Efficacy of immunotherapy approaches in metastatic and non-metastatic lung cancer models. The Journal of Immunology, 200(1_Supplement), 181-16.
  14. Munoz, L. E., Shafizadeh, Y., Margaroli, C., Bommireddy, R., & Selvaraj, P. (2018). Tumor membrane vesicle (TMV)-based cancer vaccine induces dendritic cell maturation and downstream T cell activation. The Journal of Immunology, 200(1_Supplement), 181-12.
  15. Bozeman, E. N., He, S., Shafizadeh, Y., & Selvaraj, P. (2016). Therapeutic efficacy of PD-L1 blockade in a breast cancer model is enhanced by cellular vaccines expressing B7-1 and glycolipid-anchored IL-12. Human Vaccines & Immunotherapeutics, 12(2), 421-430.
  16. Patel, J. M., Vartabedian, V. F., Bozeman, E. N., Caoyonan, B. E., Srivatsan, S., Pack, C. D., ... & Selvaraj, P. (2016). Plasma membrane vesicles decorated with glycolipid-anchored antigens and adjuvants via protein transfer as an antigen delivery platform for inhibition of tumor growth. Biomaterials, 74, 231-244.
  17. Nagarajan, S., M. Anderson S. N. Ahmed, K. W. Sell.and P.SELVARAJ. Purification and optimizationof functional reconstitution on the surface of leukemic cell lines ofGPI-anchored receptor III.gFcJ. Immunol. Methods 1995.184: 241-251.
  18. Wang, Y-C., L. Zhu, R. McHugh, K. W. Sell and P. SELVARAJ. Heatstable antigen/CD24 provides a costimulatory signal for the tumor specific Tcell proliferation and cytotoxicity in mice. Eur. J. Immunol. 1995; 25:1163-1167.
  19. McHugh, R., L. Cobrn, and P. SELVARAJ. Differences in surface expression of adhesionmolecules on cytotoxic and non-cytotoxic NK 3.3 cells. Leukocyte Typing V :1574-1576. (Oxford Univ. Press 1993).
  20. Kuchroo VK, Steele JK, O' Hara Jr RM, Jayaraman S, SELVARAJ P,Greenfield E, Kubo RT, and Dorf, ME. Relationships between antigen specific helper and inducer suppressor Tcell hybridomas. J. Immunol. 1990; 145:438-448
  21. Carpen O, SELVARAJ P, Hibbs ML, and Springer TA. The ability of NK cell and granulocyte formsof CD16 to trigger cytolytic function.Natural Killer cells: Biology and Clinical Application. 1990; pp50-54 (Proc. of 6th Int. Natural KillerCell Workshop Goslar 1989. Ed: R.E. Schmidt, Kargerpublications).
  22. KuchrooVJ, Steele JK, Billings P, SELVARAJ P, and Dorf ME. Antigenbinding CD3 bearing suppressor T cell hybridoma: I. Expression of CD3 associatedantigen binding receptors on suppressor T cells. Proc. Natl. Acad. Sci. (USA) 1988; 85:9209-9213
  23. Hollander N, SELVARAJ P, and Springer, TA. Biosynthesis and functionof LFA-3 in human mutant cells deficient in phosphatidylinositol -anchoredproteins. J. Immunol. 1988; 141: 4283-4290
  24. Dustin ML, SELVARAJ P, Mattaliano R, and Springer, TA. Anchoring mechanisms for LFA-3 cell adhesionglycoprotein at membrane surface. Nature1987; 329: 846-848
  25. SELVARAJ P, Dustin ML, Silber R, Low MG, and Springer, TA. Deficiency of lymphocyte function associatedantigen- 3 (LFA-3) in Paroxysmal Nocturnal Hemoglobinuria: Functional correlatesand evidence for a phosphatidylinositol membrane anchor. J. Exp. Med. 1987; 166:1011-1025.
  26. SELVARAJ P Dustin, R. Mitnacht, T. Hunig, T.A. Springer and M.L.Plunkett. Rosetting of humanT-lymphocytes with sheep and human erythrocytes: Comparison of human and sheep ligands bindingusing purified E receptor. J. Immunol. 1987; 138:2690-2695.
  27. Plunkett M.L., M.E. Sanders, P. SELVARAJ, M.L. Dustin, S. Shaw andT.A. Springer. Rosetting of activated T-lymphocytes with autologouserythrocytes: Definition of the receptor and ligand molecules as CD2 andlymphocyte function associated antigen-3 (LFA-3). J. Exp. Med. 1987; 165:664-676.
  28. SELVARAJ P, Plunkett ML, Dustin ML, Sanders ME, Shaw, S and Springer,TA. The T-lymphocyte glycoprotein CD2binds the cell surface ligand LFA-3. Nature 1987; 326: 400-403.
  29. SELVARAJ P, Balasubramanian KA. Comparative structural and lectin binding studies ongamma-glutamyltransferase from human adult liver, fetal liver and primaryhepatoma. Eur. J. Biochem. 1985; 153: 485-490.
  30. SELVARAJ P. Studies ongamma-glutamyl transferase from human fetal liver, normal adult liver andprimary hepatoma. Ph.D. Thesis,University of Madras, May 1984.
  31. SELVARAJ P., K.A.Balasubramanian. Formation of Co2+- Triscomplex and its interference in kinetic assay of enzymes: with special referenceto apparent inhibition of gamma-glutamyltransferase. Ind. J. Biochem. Biophys. 1984; 21:389-391.
  32. SELVARAJ P, Rolston, DDK. and Balasubramanian, KA. Separation of hydrophobic and hydrophilicforms of gamma- glutamyltransferase from human serum by hydrophobicchromatography on phenyl-sepharose CL-4B: studies on normal sera and sera ofpatients with liver disease. Clin. Chim.Acta. 1984; 138: 141-149.
  33. SELVARAJ P, Balasubramanian KA. Comparison of electrophoretic andimmunological properties of gamma- glutamyltransferase from human adult liver,fetal liver and primary hepatoma. Enzyme. 1983; 30: 21-28.
  34. SELVARAJ P, Balasubramanian KA. Soluble forms of gamma - glutamyltransferasein human adult liver, fetal liver and primary hepatoma compared. Clin. Chem.1983; 29: 90-95.
  35. SELVARAJ P, Balasubramanian, KA. Localization of gamma- glutamyl transferase on polyacrylamide gels usingL- gamma- glutamyl-p-nitroanilide as substrate. Clin. Chim. Acta. 1982; 121:291-300
  36. SELVARAJ P, Balasubramanian KA, and Hill, PG.Isolation of gamma-glutamyltransferase fromhuman primary hepatoma and comparison ofits kinetic and catalytic properties with the enzyme from normal and fetalliver. Enzyme. 1981; 26: 57-63.

Profile Details

https://winshipcancer.emory.edu/profiles/selvaraj-periasamy.php
https://scholar.google.com/citations?user=x5aE61gAAAAJ&hl=en
http://professorselvaraj.net/
https://www.researchgate.net/profile/Periasamy-Selvaraj
https://loop.frontiersin.org/people/2171411

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