Dr. Lun-Quan Sun
Central South University, China

Email: lun-quan.sun@uts.edu.au

Qualifications

Professor, Central South University, China

Director, Central South University, China

Chairman, Central South University, China

Professor, University of Technology Sydney, Australia

Publications (Selected)

1. Cong H, Sun LQ, Liu C, Tien P. (2010) Inhibition of atrogin-1/MAFbx expression by adenovirus- delivered shRNAs attenuates muscle atrophy in fasting mice. Hum Gene Ther. 2010 Dec 2. [Epub ahead of print]
2. Sun J, Hu Y, Cao S, Zhang G, Sun LQ*, Wang M* (2010) Acute, multiple-dose dermal and genetic toxicity of Nu-3: a novel antimicrobial agent. J Biomed Biotechnol. 2010;2010. pii: 362524.
3. Lifang Yang, Zhongxin Lu, Xiaoqian Ma, Ya Cao* and LQ Sun* (2010). A Therapeutic Approach to Nasopharyngeal Carcinomas by DNAzymes Targeting EBV LMP-1 Gene. Molecules 15, 6127-6139.
4. Wang ZL, FJ Luo, L Li, LF Yang, DS Hu, XQ Ma, ZX Lu, LQ Sun*, Y Cao,* (2010) STAT3 activation induced by Epstein-Barr virus latent membrane protein1 causes vascular endothelial growth factor expression and cellular invasiveness via JAK3 And ERK signaling Eur J Cancer. 46(16):2996-3006.
5. Wong JP, Christopher ME, Salazar AM, Sun LQ, Viswanathan S, Wang M, Saravolac EG, Cairns MJ.(2010) Broad-spectrum and virus-specific nucleic acid-based antivirals against influenza. Front Biosci. 2:791-800.
6. Wong JP, Christopher ME, Viswanathan S, Dai X, Salazar AM, Sun LQ*. (2009) Antiviral role of toll-like receptor-3 agonists against seasonal and avian influenza viruses. Curr Pharm Design. 15 (11):1269-74.
7. Yang L, Xiao L, Ma X, Tang M, Weng X, Chen X, Sun L*, Cao Y*. (2009) Effect of DNAzymes targeting Akt1 on cell proliferation and apoptosis in nasopharyngeal carcinoma. Cancer Biol Ther. 8(4):366-71.
8. Yang L, Ma X, Xiao L, Tang M, Weng X, Sun L*, Cao Y. Uniquely modified RNA oligonucleotides targeting STAT3 suppress melanoma growth both in vitro and in vivo. Cancer Biol Ther, 2009,8 (21):2065-2072.
9. Dale R, Wang M and Sun LQ* (2008) Inhibition of Highly Pathogenic Avian H5N1 Influenza Virus Replication by NanoRNA Oligonucleotides. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 7:101-105.
10. Chang-Mei Liu, Zhuo Yang, Chao-Wu Liu, Rong Wang, Po Tien, Rod Dale, L-Q Sun* (2008) Myostatin Antisense RNA-mediated Muscle Growth in Normal and Cancer Cachexia Mice. Gene Therapy, 15(3):155-60.
11. Yang ZA retrovirus-based system to stably silence GDF-8 expression and enhance myogenic differentiation in human rhabdomyosarcoma cells. J Gene Med. 10(8):825-33., Zhang J, Cong H, Huang Z, , Sun LQ*, Tien P* (2008)
12. Lu ZX, Ma XQ, Yang LF, Wang ZL, Zeng L, Li ZJ, Li XN, Tang M, Yi W, Gong JP, Sun LQ*, Cao Y* (2008) DNAzymes targeted to EBV-encoded latent membrane protein-1 induce apoptosis and enhance radiosensitivity in nasopharyngeal carcinoma. Cancer Lett doi:10.1016/j.canlet.2008.02.019
13. Yanhua Wu， Guozhong Zhang, Yi Li, Yi Jin, Rod Dale, Sun LQ* and M Wang* （2008）Inhibition of Highly Pathogenic Avian H5N1 Influenza Virus Replication by RNA Oligonucleotides Targeting NS1 Gene. Biochem Biophys Res Commu 365: 369-374.
14. Chang-Mei Liu, Zhuo Yang, Chao-Wu Liu, Rong Wang, Po Tien, Roderick Dale and L-Q Sun* (2007). Effect of RNA oligonucleotide targeting Foxo-1 on muscle growth in normal and cancer cachexia mice. Cancer Gene Therapy, 14(12):945-52.
15. Wong JP, Christopher ME, Carins, M, Sun LQ, Dale RMK and Salazar AM (2007) Current status on development of nucleic acid-based antiviral drugs against influenza infections. In Combating the threat of pandemic influenza: Drug Discovery Approaches. Ed. Paul P Torrence, John Wiley, pp126-147.
16. Shuwen Wu, Junqiang Xu, Jiangxia Liu, Xuan Yan, Xiaodong Zhu, Gengfu Xiao, Po Tien and L-Q Sun*(2007) An efficient RNA-cleaving DNA enzyme can specifically target the 5’-untranslated region of Severe Acute Respiratory Syndrome associated Coronavirus (SARS-CoV). J Gene Medicine 9:1080-6.
17. Bhindi R, Fahmy RG, Lowe HC, Chesterman CN, Dass CR, Cairns MJ, Saravolac EG, Sun L-Q*, Khachigian LM* (2007). Brothers in arms: DNAzymes, siRNA and the emerging wave of small molecule nucleic acid-based gene silencing strategies. American Journal of Pathology 171(4): 1079-1088.
18. J.P. Wong, M.E. Christopher, A.M. Salazar, R.M.K. Dale, LQ. Sun, M. Wang (2007) Nucleic acid-based antiviral drugs against seasonal and avian influenza viruses. Vaccine doi:10.1016; .01.051.
19. ZX Lu, M Ye, GR Yan, M Tang LM Lee, Sun LQ*, Y Cao* (2005) Effect of EBV-LMP1 targeted DNAzymes on cell proliferation and apoptosis. Cancer Gene Therapy, 12(7):647-54.
20. Sun LQ* (2005) Use of deoxyribozymes for gene knockdown. Medicinal Chemistry, 2(1):81-87.