Biography

Prof. David Vauzour

Faculty of Medicine and Health Sciences

University of East Anglia, UK

Research Fellow


Email: D.Vauzour@uea.ac.uk


Qualifications

2004 Ph.D., University of Montpellier, France, Chemical and Biological Sciences for Health

2001 M.Sc., University of Bordeaux, France, Biological and Medical Sciences

1999 B.Sc., University of Bordeaux, France, Molecular and Cellular Biochemistry/Pharmacology


Publications (selected)

  1. VAUZOUR, D., PINTO, J. T., COOPER, A. J. & SPENCER, J. P. 2014. The neurotoxicity of 5-S-cysteinyldopamine is mediated by the early activation of ERK1/2 followed by the subsequent activation of ASK1/JNK1/2 pro-apoptotic signalling. Biochem J, vol. 463, no. 1, pp. 41-52.http://dx.doi.org/10.1042/BJ20131519
  2. VAUZOUR, D. 2014. Effect of flavonoids on learning, memory and neurocognitive performance: relevance and potential implications for Alzheimer's disease pathophysiology. J Sci Food Agric, vol. 94, no. 6, pp. 1042-56. http://dx.doi.org/10.1002/jsfa.6473
  3. RODRIGUEZ-MATEOS, A., VAUZOUR, D., KRUEGER, C. G., SHANMUGANAYAGAM, D., REED, J., CALANI, L., MENA, P., DEL RIO, D. & CROZIER, A. 2014. Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an update. Arch Toxicol, vol., no.http://dx.doi.org/10.1007/s00204-014-1330-7
  4. RENDEIRO, C., FOLEY, A., LAU, V. C., RING, R., RODRIGUEZ-MATEOS, A., VAUZOUR, D., WILLIAMS, C. M., REGAN, C. & SPENCER, J. P. 2014. A role for hippocampal PSA-NCAM and NMDA-NR2B receptor function in flavonoid-induced spatial memory improvements in young rats. Neuropharmacology, vol. 79, no. 335-44. http://dx.doi.org/10.1016/j.neuropharm.2013.12.003
  5. RENDEIRO, C., VAUZOUR, D., RATTRAY, M., WAFFO-TEGUO, P., MERILLON, J. M., BUTLER, L. T., WILLIAMS, C. M. & SPENCER, J. P. 2013. Dietary levels of pure flavonoids improve spatial memory performance and increase hippocampal brain-derived neurotrophic factor. PLoS One, vol. 8, no. 5, pp. e63535. http://dx.doi.org/10.1371/journal.pone.0063535
  6. CORONA, G., VAUZOUR, D., HERCELIN, J., WILLIAMS, C. M. & SPENCER, J. P. 2013. Phenolic acid intake, delivered via moderate champagne wine consumption, improves spatial working memory via the modulation of hippocampal and cortical protein expression/activation. Antioxid Redox Signal, vol. 19, no. 14, pp. 1676-89. http://dx.doi.org/10.1089/ars.2012.5142
  7. VAUZOUR, D. 2012. Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects. Oxid Med Cell Longev, vol. 2012, no. 914273. http://dx.doi.org/10.1155/2012/914273
  8. SPILSBURY, A., VAUZOUR, D., SPENCER, J. P. & RATTRAY, M. 2012. Regulation of NF-kappaB activity in astrocytes: effects of flavonoids at dietary-relevant concentrations. Biochem Biophys Res Commun, vol. 418, no. 3, pp. 578-83. http://dx.doi.org/10.1016/j.bbrc.2012.01.081
  9. SPENCER, J. P., VAFEIADOU, K., WILLIAMS, R. J. & VAUZOUR, D. 2012. Neuroinflammation: modulation by flavonoids and mechanisms of action. Mol Aspects Med, vol. 33, no. 1, pp. 83-97. http://dx.doi.org/10.1016/j.mam.2011.10.016
  10. RENDEIRO, C., VAUZOUR, D., KEAN, R. J., BUTLER, L. T., RATTRAY, M., SPENCER, J. P. & WILLIAMS, C. M. 2012. Blueberry supplementation induces spatial memory improvements and region-specific regulation of hippocampal BDNF mRNA expression in young rats. Psychopharmacology (Berl), vol. 223, no. 3, pp. 319-30. http://dx.doi.org/10.1007/s00213-012-2719-8
  11. VAUZOUR, D., RODRIGUEZ-MATEOS, A., CORONA, G., ORUNA-CONCHA, M. J. & SPENCER, J. P. 2010a. Polyphenols and human health: prevention of disease and mechanisms of action. Nutrients, vol. 2, no. 11, pp. 1106-31. http://dx.doi.org/10.3390/nu2111106
  12. VAUZOUR, D., HOUSEMAN, E. J., GEORGE, T. W., CORONA, G., GARNOTEL, R., JACKSON, K. G., SELLIER, C., GILLERY, P., KENNEDY, O. B., LOVEGROVE, J. A. & SPENCER, J. P. 2010b. Moderate Champagne consumption promotes an acute improvement in acute endothelial-independent vascular function in healthy human volunteers. Br J Nutr, vol. 103, no. 8, pp. 1168-78. http://dx.doi.org/10.1017/S0007114509992959
  13. VAUZOUR, D., CORONA, G. & SPENCER, J. P. 2010c. Caffeic acid, tyrosol and p-coumaric acid are potent inhibitors of 5-S-cysteinyl-dopamine induced neurotoxicity. Arch Biochem Biophys, vol. 501, no. 1, pp. 106-11. http://dx.doi.org/10.1016/j.abb.2010.03.016
  14. VAUZOUR, D., BUONFIGLIO, M., CORONA, G., CHIRAFISI, J., VAFEIADOU, K., ANGELONI, C., HRELIA, S., HRELIA, P. & SPENCER, J. P. 2010d. Sulforaphane protects cortical neurons against 5-S-cysteinyl-dopamine-induced toxicity through the activation of ERK1/2, Nrf-2 and the upregulation of detoxification enzymes. Mol Nutr Food Res, vol. 54, no. 4, pp. 532-42. http://dx.doi.org/10.1002/mnfr.200900197
  15. VAFEIADOU, K., VAUZOUR, D., LEE, H. Y., RODRIGUEZ-MATEOS, A., WILLIAMS, R. J. & SPENCER, J. P. 2009. The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury. Arch Biochem Biophys, vol. 484, no. 1, pp. 100-9.http://dx.doi.org/10.1016/j.abb.2009.01.016
  16. SPENCER, J. P., VAUZOUR, D. & RENDEIRO, C. 2009. Flavonoids and cognition: the molecular mechanisms underlying their behavioural effects. Arch Biochem Biophys, vol. 492, no. 1-2, pp. 1-9. http://dx.doi.org/10.1016/j.abb.2009.10.003
  17. WILLIAMS, C. M., EL MOHSEN, M. A., VAUZOUR, D., RENDEIRO, C., BUTLER, L. T., ELLIS, J. A., WHITEMAN, M. & SPENCER, J. P. 2008. Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels. Free Radic Biol Med, vol. 45, no. 3, pp. 295-305. http://dx.doi.org/10.1016/j.freeradbiomed.2008.04.008
  18. VAUZOUR, D., VAFEIADOU, K., RODRIGUEZ-MATEOS, A., RENDEIRO, C. & SPENCER, J. P. 2008a. The neuroprotective potential of flavonoids: a multiplicity of effects. Genes Nutr, vol. 3, no. 3-4, pp. 115-26. http://dx.doi.org/10.1007/s12263-008-0091-4
  19. VAUZOUR, D., RAVAIOLI, G., VAFEIADOU, K., RODRIGUEZ-MATEOS, A., ANGELONI, C. & SPENCER, J. P. 2008b. Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1: implications for Parkinson's disease and protection by polyphenols. Arch Biochem Biophys, vol. 476, no. 2, pp. 145-51. http://dx.doi.org/10.1016/j.abb.2008.03.011
  20. VAFEIADOU, K., VAUZOUR, D., RODRIGUEZ-MATEOS, A., WHITEMAN, M., WILLIAMS, R. J. & SPENCER, J. P. 2008. Glial metabolism of quercetin reduces its neurotoxic potential. Arch Biochem Biophys, vol. 478, no. 2, pp. 195-200. http://dx.doi.org/10.1016/j.abb.2008.07.014


Profile Details

https://www.uea.ac.uk/medicine/people/profile/d-vauzour#overviewTab

http://www.researcherid.com/rid/C-2245-2008


Last Updated: 2014-09-11

Free SCIRP Newsletters
Copyright © 2006-2025 Scientific Research Publishing Inc. All Rights Reserved.
Top