Dr. Jithesh Kottur

Icahn School of Medicine at Mount Sinai, New York, USA

Post-doctoral Fellow

Email: jithesh.kottur@mssm.edu

Qualifications

2017 Ph.D., Regional Centre for Biotechnology, India.

2011 M.Sc., Kannur University, India.

Publications (Selected)

1. Karakus, U., Mena, I., Kottur, J., El Zahed, S. S., Seoane, R., Yildiz, S., ... & García-Sastre, A. (2024). H19 influenza A virus exhibits species-specific MHC class II receptor usage. Cell host & microbe, 32(7), 1089-1102.
2. Nandu, T. G., & Jithesh, K. (2024). Natural Product-Based Anti-Viral Agents Against RNA Viruses: An Important Strategy for Pandemic Preparedness. In Drugs from Nature: Targets, Assay Systems and Leads (pp. 411-440). Singapore: Springer Nature Singapore.
3. Rechkoblit, O., Sciaky, D., Kreitler, D. F., Buku, A., Kottur, J., & Aggarwal, A. K. (2024). Activation of CBASS Cap5 endonuclease immune effector by cyclic nucleotides. Nature Structural & Molecular Biology, 31(5), 767-776.
4. Kottur, J., Malik, R., & Aggarwal, A. K. (2024). Nucleic acid mediated activation of a short prokaryotic Argonaute immune system. Nature Communications, 15(1), 4852.
5. Aggarwal, A. K., Kottur, J., & Malik, R. (2023). Nucleic Acid Mediated Activation of a Short Prokaryotic Argonaute Immune System. Biorxiv: the Preprint Server for Biology.
6. Kottur, J., White, K. M., Rodriguez, M. L., Rechkoblit, O., Quintana-Feliciano, R., Nayar, A., ... & Aggarwal, A. K. (2023). Structures of SARS-CoV-2 N7-methyltransferase with DOT1L and PRMT7 inhibitors provide a platform for new antivirals. PLoS Pathogens, 19(7), e1011546.
7. Kottur, J., Rechkoblit, O., Quintana-Feliciano, R., Sciaky, D., & Aggarwal, A. K. (2022). High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development. Nature structural & molecular biology, 29(9), 850-853.
8. Li, D., Yu, X., Kottur, J., Gong, W., Zhang, Z., Storey, A. J., ... & Wang, G. G. (2022). Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic. Oncogene, 41(24), 3328-3340.
9. Aggarwal, A., & Kottur, J. (2022). High resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development. Research Square, rs-3.
10. Yu,X., Li,D., Kottur,J., Shen,Y., Kim,H.S., Park,K.-S., Tsai,Y.-H., Gong,W., Wang,J., Suzuki,K., et al. (2021) A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models. Sci Transl Med, 13, eabj1578. (Equal Contribution).
11. Johnson, M.K., Kottur, J and Nair, D.T. (2019) A polar filter in DNA polymerases prevents ribonucleotide incorporation Nucleic Acids Res. 47, 10693-10705.
12. Kottur, J and Nair, D. T. (2018) Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction. Nucleic Acids Res.46, 5875-5885.
13. Kottur, J. and Nair, D.T. (2016) Reactive Oxygen Species Play an Important Role in the Bactericidal Activity of Quinolone Antibiotics. Angew Chem Int Ed Engl, 55, 2397-2400.
14. Ghodke, P.P., Gore, K.R., Harikrishna, S., Samanta, B., Kottur, J., Nair, D.T. and Pradeepkumar, P.I. (2016) The N(2)-Furfuryl-deoxyguanosine Adduct Does Not Alter the Structure of B-DNA. J Org Chem, 81, 502-511.
15. Weinert, T., Olieric, V., Waltersperger, S., Panepucci, E., Chen, L., Zhang, H., Zhou, D., Rose, J., Ebihara, A., Kuramitsu, S., Kottur, J. et al. (2015) Fast native-SAD phasing for routine macromolecular structure determination. Nature Methods, 12, 131-133.
16. Kottur, J., Sharma, A., Gore, K.R., Narayanan, N., Samanta, B., Pradeepkumar, P.I. and Nair, D.T. (2015) Unique structural features in DNA polymerase IV enable efficient bypass of the N2 adduct induced by the nitrofurazone antibiotic. Structure, 23, 56-67.
17. Nair, D.T., Kottur, J. and Sharma, R. (2015) A rescue act: Translesion DNA synthesis past N(2) -deoxyguanosine adducts. IUBMB Life, 67, 564-574.
18. Sharma, A., Kottur, J., Narayanan, N. and Nair, D.T. (2013) A strategically located serine residue is critical for the mutator activity of DNA polymerase IV from Escherichia coli. Nucleic acids research, 41, 5104-5114.
19. Khan, M. and Jithesh, K. (2012) Expression and purification of organic solvent stable lipase from soil metagenomic library. World J Microbiol Biotechnol, 28, 2417-2424.
20. Khan, M., Jithesh, K. and Mookambikay, R. (2013) Cloning and characterization of two functionally diverse lipases from soil metagenome. J Gen Appl Microbiol, 59, 21-31.

Profile Details

https://scholar.google.com/citations?user=ICHHFD0AAAAJ&hl=en
https://orcid.org/0000-0002-8075-3883
https://www.researchgate.net/profile/Jithesh-Kottur-2
https://loop.frontiersin.org/people/2153657/overview