Dr. Srihari Konduri

University of California San Diego (UCSD) Skaggs School of Pharmacy and Pharmaceutical Sciences 9500 Gilman Drive La Jolla, CA 92093, USA.

Staff Research Associative-3

Email: skonduri@ucsd.edu

Qualifications

2021 Ph.D., Chemistry, Vignan University, Guntur, India

2008 M.Sc., Organic chemistry, Andhra University, India

2006 B.Sc., Acharya Nagarjuna University, India

Publications (Selected)

1. Ertunc, Meric & Konduri, Srihari & Ma, Zhichen & Pinto, Antonio & Donaldson, Cindy & Momper, Jeremiah & Siegel, Dionicio & Saghatelian, Alan. (2024). Acute inflammation upregulates FAHFAs in adipose tissue and in co-cultured adipocytes. Journal of Biological Chemistry. 300. 107972. 10.1016/j.jbc.2024.107972. 
2. ISMAIL SYED, KENNETH SLUIS, PRATIK ARYAL, ZACHARY SOLOMON, RUCHA PATEL, SRIHARI KONDURI, DIONICIO SIEGEL, ULF SMITH, BARBARA B. KAHN; 125-OR: New Lipid Biomarkers for Worsening Glucose Tolerance in Nondiabetic Relatives of People with Type 2 Diabetes. Diabetes 14 June 2024; 73 (Supplement_1): 125–OR. https://doi.org/10.2337/db24-125-OR
3. Bhargavi, & Konduri, Srihari & Prashanth, Jyothi & Pulipati, Sowjanya & Praneeth, K. & Sireesha, Malladi & Koya, Prabhakara. (2023). Synthesis and identification of new sacubitril derivatives as lead compounds for antibacterial, antifungal and antitubercular (TB) activities against dormant tuberculosis. RSC Advances. 13. 13540-13546. 10.1039/D3RA00713H. 
4. Bhargavi, & Konduri, Srihari & Prashanth, Jyothi & Sireesha, Malladi & Koya, Prabhakara. (2023). Piperazine‐ and Pyrazole‐Based Heterocyclic Scaffold Derivatives Connected with Urea and Thiourea for Anti‐Inflammatory Activity. ChemistrySelect. 8. 10.1002/slct.202300238. 
5. Tan, Dan & Konduri, Srihari & Ertunc, Meric & Zhang, Pan & Wang, Justin & Chang, Tina & Pinto, Antonio & Rocha, Andréa & Donaldson, Cindy & Vaughan, Joan & Ludwig, Raissa & Willey, Elizabeth & Iyer, Manasi & Gray, Peter & Maher, Pamela & Allen, Nicola & Zuchero, J. Bradley & Dillin, Andrew & Mori, Marcelo & Saghatelian, Alan. (2022). A class of anti-inflammatory lipids decrease with aging in the central nervous system. Nature Chemical Biology. 19. 1-11. 10.1038/s41589-022-01165-6. 
6. Patel, Rucha & Santoro, Anna & Hofer, Peter & Tan, Dan & Oberer, Monika & Nelson, Andrew & Konduri, Srihari & Siegel, Dionicio & Zechner, Rudolf & Saghatelian, Alan & Kahn, Barbara. (2022). ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids. Nature. 606. 1-8. 10.1038/s41586-022-04787-x. 
7. Zhang, Wen & Xue, Yansong & Konduri, Srihari & Lin, Guodan & Wu, Mengjuan & Tang, Pei & Chen, Fener. (2022). Unified total synthesis of eburnamine-vincamine indole alkaloids based on catalytic asymmetric hydrogenation/lactamization cascade. Green Synthesis and Catalysis. 3. 10.1016/j.gresc.2022.05.001. 
8. Medellin, Brenda & Yang, Wanjie & Konduri, Srihari & Dong, Jiajun & Irani, Seema & Wu, Haoyi & Matthews, Wendy & Zhang, Zhong-Yin & Siegel, Dionico & Zhang, Yan. (2021). Targeted Covalent Inhibition of Small CTD Phosphatase 1 to Promote the Degradation of the REST Transcription Factor in Human Cells. Journal of Medicinal Chemistry. 65. 10.1021/acs.jmedchem.1c01655. 
9. Konduri, Srihari & Pogaku, Vinay & Prashanth, Jyothi & Krishna, Vagolu & Sriram, Dharmarajan & Srinivas, Basavoju & Behera, Jogendra & Koya, Prabhakara. (2021). Sacubitril‐Based Urea and Thiourea Derivatives as Novel Inhibitors for Anti‐Tubercular against Dormant Tuberculosis. ChemistrySelect. 6. 3869-3874. 10.1002/slct.202004724. 
10. Srihari Konduri, Jyothi Prashanth, Vagolu Siva Krishna, Dharmarajan Sriram, JN Behera, Dionicio Siegel, Koya Prabhakara Rao. “Design and synthesis of purine connected piperazine derivatives as novel inhibitors of Mycobacterium tuberculosis’’. Bioorganic & Medicinal Chemistry Letters, (2020) 30, 127512
11. Srihari Konduri, Dodda Bhargavi, Jyothi Prashanth, Vagolu Siva Krishna, Dharmarajan Sriram, and Koya Prabhakara Rao. “Design and Synthesis of ‘Chloropicolinate Amides and Urea Derivatives’ as Novel Inhibitors for Mycobacterium Tuberculosis’’. ACS Omega. (2021) 6(2), 1657–1667
12. Srihari Konduri, Vinay Pogaku, Jyothi Prashanth, Vagolu Siva Krishna, Dharmarajan Sriram, Srinivas Basavoju, J. N. Behera, Koya Prabhakara Rao. “Sacubitril Based Urea and Thiourea Derivatives as Novel Inhibitors for Anti-tubercular against Dormant Tuberculosis’’. Chemistry Select, (2021) 6, 3869-3874
13. Dan Tan, Meric Erikci Ertunc, Srihari Konduri, Justin Zhang, Antonio M. Pinto, Qian Chu, Barbara B. Kahn, Dionicio Siegel, and Alan Saghatelian. “Discovery of FAHFA-Containing Triacylglycerols and Their Metabolic Regulation”. J. Am. Chem. Soc. (2019) 141, 22, 8798-8806
14. Matthew J. Kolar, Srihari Konduri, Tina Chang, Huijing Wang, Clare McNerlin, Lena Ohlsson, MagnusHärröd, DionicioSiegel, AlanSaghatelian. “Linoleic acid esters of hydroxylinoleic acids are anti-inflammatory lipids found in plants and mammals”. J. Biol. Chem. (2019) 294(27) 10698–10707
15. Huijing Wang, Matthew J Kolar, Tina Chang, José Rizo, Srihari Konduri, Clare McNerlin, Alan Saghatelian, Dionicio Siegel. “Stereochemistry of Linoleic Acid Esters of Hydroxy Linoleic Acids”. Org. Lett. 2019, 21, 19, 8080-8084
16. Kummetha Indrasena Reddy, Konduri Srihari, Renuka Reddy, K. Sudhakar Babu, D. Sriram, J.P. Sridevi, P. Yogeeswari. “An efficient synthesis and biological screening of benzofuranand benzo[d]isothiazole derivatives for Mycobacterium tuberculosis DNA GyrB inhibition’’. Bioorganic & Medicinal Chemistry 22 (2014) 6552–6563
17. Renuka Reddy, Kummetha Indrasena Reddy, Konduri Srihari, K. Sudhakar Babu, D. Sriram, J. P. Sridevi, P. Yogeeswari. “Design, synthesis, biological evaluation of substituted benzofurans as DNA gyraseB inhibitors of Mycobacterium tuberculosis”. Bioorganic & Medicinal Chemistry 22 (2014) 4924–4934
18. Huijing Wang, Tina Chang, Srihari Konduri, Jianbo Huang, Alan Saghatelian, Dionicio Siegel. “Synthesis of chemically edited derivatives of the endogenous regulator of inflammation 9-PAHSA’’. The Journal of Antibiotics (2019) 72:498–506
19. K. Indrasena Reddy, C. Aruna, M. Manisha, K. Srihari, K. Sudhakar Babu, V. Vijayakumar, S.Sarveswari, R. Priya, A. Amrita, R. Siva. “Synthesis, DNA binding and in-vitro cytotoxicity studies on novel bis-pyrazoles”. Journal of Photochemistry and Photobiology B: Biology 168 (2017) 89–97
20. Sonjiala Jackson Hotchkiss, Maria Carmen Mulero, Garrett J Chan, Tapan Biswas, Smarajit Polley, Christine Ohn, Srihari Konduri, Ozlem Demir, Rommie E Amaro, Gourisankar Ghosh. “Discovery of an IKK2 Site that Allosterically Controls Its Activation ”. bioRxiv preprint doi: https://doi.org/10.1101/2021.01.27.428502

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