Author(s)

Takafumi Tezuka, Hiroshi Shirouzu, Keigo Ishida, Noritaka Suzuki, Takuya Matsuo, Kin-ichi Oyama, Setsuyuki Aoki, Masaki Tsukamoto

Center for Gene Research, Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya, Japan.
Chemical Instrumentation Facility, Research Center for Materials Science, Nagoya University, Nagoya, Japan.
Graduate School of Information Science, Nagoya University, Nagoya, Japan.

Physiological changes in the photosynthesis, respiration and cell division of Chlamydomonas reinhardtii, a freshwater green alga, in response to adenine nucleotides were investigated. In advance of this investigation, two adenine nucleotides, di(2'-O-methyl)-cyclic bis(3'-5')diadenylic acid (1) and its N-benzoyl-protected analog 2 were synthesized from the commercially available adenosine phosphoramidite. The respective analogs significantly promoted the cell division (cell number) of C. reinhardtii strains 137c mt⁺ and BR mt⁺. Moreover, they significantly enhanced the O₂ evolution (photosynthesis) and O₂ uptake (respiration) of both strains. c-di-AMP analogs seem to play an effective role as a physiological activator in planta.

c-di-AMP; O2 Evolution (Photosynthesis); O2 Uptake (Respiration); Chlamydomonas reinhardtii

T. Tezuka, H. Shirouzu, K. Ishida, N. Suzuki, T. Matsuo, K. Oyama, S. Aoki and M. Tsukamoto, "Cyclic Bis(3'-5')diadenylic Acid (c-di-AMP) Analogs Promote the Activities of Photosynthesis and Respiration of Chlamydomonas reinhardtii," American Journal of Plant Sciences, Vol. 5 No. 1, 2014, pp. 24-28. doi: 10.4236/ajps.2014.51004.