Evolution of Post-Surgical Scars Treated with Pure Rosehip Seed Oil

Pedro Valerón-Almazán¹, Anselmo J. Gómez-Duaso¹, Néstor Santana-Molina¹, Miguel A. García-Bello², Gregorio Carretero¹

¹Dermatology Service, Hospital Universitario de Gran Canaria Dr. Negrin, Las Palmas, Spain.
²Research Unit, Hospital Universitario de Gran Canaria Dr. Negrin, Las Palmas, Spain.

DOI: 10.4236/jcdsa.2015.52019                

Abstract

The rosehip seed oil (RHO), obtained from different plant species of the genus Rosa, is one of the compounds used empirically for cosmetic improvement of skin scarring. Despite its widespread use in clinical practice, there are few studies evaluating the activity of this compound on the clinical course of cutaneous scars. The aim of this study was to determine the effect of Repavar® rosehip oil on improvement of post-surgical skin scars. One comparative, single-center, prospective clinical trial was carried out in 108 patients undergoing cutaneous surgery procedures in the Dermatology Service of University Hospital of Gran Canaria Dr. Negrín (Spain). Subjective parameters (erythema, discoloration, atrophy and hypertrophy) were evaluated at 6 and 12 weeks on 76 adults who treated scars with pure RHO twice a day (test group), 32 patients with not treatment (control group), and completed the study. Lesser degree of erythema was observed at 6 and 12 weeks in treated-patients compared with the control group and decreased discoloration and atrophy at 12 weeks, with statistically significant differences in all cases (p < 0.05). This study demonstrates that the RHO Repavar® is useful for cosmetic improvement on erythema, discoloration and atrophyof post-surgical skin scars, getting a better overall evolution and appearance thereof.

Keywords

Healing, Skin Scar, Rosa Mosqueta, Rosehip Seed Oil, Skin Surgery

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	Stadelmann, W.K., Digenis, A.G. and Tobin, G.R. (1998) Physiology and Healing Dynamics of Chronic Cutaneous Wounds. American Journal of Surgery, 176, 26-38. http://dx.doi.org/10.1016/S0002-9610(98)00183-4
[2]	Iba, Y., Shibata, A., Kato, M. and Masukawa, T. (2004) Possible Involvement of Mast Cells in Collagen Remodeling in the Late Phase of Cutaneous Wound Healing in Mice. International Immunopharmacology, 4, 1873-1880. http://dx.doi.org/10.1016/j.intimp.2004.08.009
[3]	Arndt, K.A. (2006) Scar Revision. Elsevier, Philadelphia.
[4]	McGrath, M.H. (1990) Peptide Growth Factors and Wound Healing. Clinics in Plastic Surgery, 17, 421-432.
[5]	Cohen, I.K., Diegelman, R.F. and Lindblad, W.J. (1992) Wound-Healing: Biochemical and Clinical Aspects. Annals of Surgery, 96, 114. http://dx.doi.org/10.1097/00006534-199211000-00034
[6]	Mustoe, T.A., Cooter, R.D., Gold, M.H., Hobbs, F.D., Ramelet, A.A. and Shakespeare, P.G. (2002) International Clinical Recommendations on Scar Management. Plastic and Reconstructive Surgery, 110, 560-571. http://dx.doi.org/10.1097/00006534-200208000-00031
[7]	Dogan, A. and Kazankaya, A. (2006) Properties of Hose Hip Species Grown in Lake Van Basin (Eastern Anatolia Region). Asian Journal of Plant Sciences, 5, 120-122. http://dx.doi.org/10.3923/ajps.2006.120.122
[8]	Ozcan, M. (2002) Nutrient Composition of Rose (Rosa canina L.) Seed and Oils. Journal of Medicinal Food, 5, 137-140. http://dx.doi.org/10.1089/10966200260398161
[9]	Valladares, J., Palma, M., Sandoval, C. and Carvajal, F. (1986) Cream Hip Oil (Rosa aff. rubiginosa I.). Part I: Formulation, Preparation and Primary Application in Tissue Regeneration. Annals Real Acad Farm., 52, 597-612.
[10]	Santos, J.S., Vieira, A.B. and Kamada, I. (2009) The Rosehip Not Open Wounds Treatment: A Review. Revista Brasileira de Enfermagem, 62, 457-462. http://dx.doi.org/10.1590/S0034-71672009000300020
[11]	Moreno, J.C., Good, J., Navas, J. and Camacho, F. (1990) Treatment of Cutaneous Ulcers with Musk Rose Oil. Cutan Med Ibero Lat Am., 18, 63-66.
[12]	Camacho, F., Moreno, J.C., Conejo-Mir, J. and Bueno, J. (1994) Treatment of Post-Surgical Scars and Pure Oil Rosehip Seed Defects. Cutan Med Ibero Lat Am., 22, 23-30.
[13]	Marchini, F.B., Martins, D.M., Teves, D.C. and Simoes, M.J. (1988) Rosehip Oil Effect on the Healing of Open Wounds. Revista Paulista de Medicina, 106, 356.
[14]	Hakansson, A., Stene, C., Milhaescu, A., Molin, G., Ahrné, S. and Thorlacius, H. (2006) Rose Hip and Lactobacillus plantarum DSM 9843 Reduces Ischemia/Reperfusion Injury in the Mouse Colon. Digestive Diseases and Sciences, 51, 2094-2101. http://dx.doi.org/10.1007/s10620-006-9170-9
[15]	Daels-Rakotoarison, D.A., Gressier, B., Trotin, F., Brunet, C., Luyckx, M. and Dine, T. (2002) Effects of Rosa canina Fruit Extract on Neutrophil Respiratory Burst. Phytotherapy Research, 16, 157-161. http://dx.doi.org/10.1002/ptr.985
[16]	Larsen, E., Kharazmi, A., Christensen, L.P. and Christensen, S.B. (2003) An Antiinflammatory Galactolipid from Rose Hip (Rosa canina) That Inhibits Chemotaxis of Peripheral Blood Neutrophils in Vitro Huma. Journal of Natural Products, 66, 994-995. http://dx.doi.org/10.1021/np0300636
[17]	Robert, P., Carlsson, R.M., Romero, N. and Masson, L. (2003) Stability of Spray-Dried Encapsulated Carotenoid Pigments from Rosehip (Rosa rubiginosa) Oleoresin. Journal of the American Oil Chemists’ Society, 80, 1115-1120. http://dx.doi.org/10.1007/s11746-003-0828-4
[18]	Salminen, J.P., Karonen, M., Lempa, K., Liimatainen, J., Sinkkonen, J. and Lukkarinen, M. (2005) Characterisation of Proanthocyanidin Aglycones and Glycosides from Rose Hips by High-Performance Liquid Chromatography-Mass Spectrometry, and Their Rapid Quantification Together with Vitamin C. Journal of Chromatography A, 1077, 170-180. http://dx.doi.org/10.1016/j.chroma.2005.04.073
[19]	Torok, H.M. and Pillai, R. (2011) Safety and Efficacy of Micronized Tretinoin Gel (0.05%) in Treating Adolescent Acne. Journal of Drugs in Dermatology, 10, 647-652.
[20]	Ting, W. (2010) Tretinoin for the Treatment of Photodamaged Skin. Cutis, 86, 47-52.
[21]	Harris, D.W., Buckley, C.C., Ostlere, L.S. and Rustin, M.H. (1991) Topical Retinoic Acid in the Treatment of Acne Scarring Fine. British Journal of Dermatology, 125, 81-82. http://dx.doi.org/10.1111/j.1365-2133.1991.tb06048.x
[22]	de Limpens A.M., J. (1980) The Local Treatment of Hypertrophic Scars and Keloids with Topical Retinoic Acid. British Journal of Dermatology, 103, 319-323. http://dx.doi.org/10.1111/j.1365-2133.1980.tb07251.x
[23]	Berman, B., Villa, A.M. and Ramirez, C.C. (2004) Novel Opportunities in the Treatment and Prevention of Scarring. Journal of Cutaneous Medicine and Surgery, 8, 32-36. http://dx.doi.org/10.1007/s10227-004-0806-0