Biaxial Constitutive Model of Active Coronary Media Based on Microstructural Information

Huan Chen, Yunlong Huo, Ghassan S. Kassab

Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, USA.
Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, USA Department of Surgery, Cellular and Integrative Physiology, Indiana University Purdue University Indianapolis, Indianapolis, USA.
Mechanics and Engineering Science, State Key Laboratory for Turbulence and Complex Systems, College of Engineering, Peking University, Beijing, China.

DOI: 10.4236/eng.2013.510B069                

Abstract

Detailed morphological data of vascular smooth muscle cells (VSMC) of coronary arteries were limited. The present study was to quantify dimensions and orientation of swine coronary VSMC and to develop a micro-structural constitutive model of active media. It was found that geometrical parameters of VSMC (length, width, spatial aspect ratio, and orientation) follow normal distributions, and VSMCs orientate towards the circumferential direction of vessels with oblique and symmetrical angles. A micro-structural model of media layer was developed to accurately predict biaxial active responses of coronary arterial media, based on experimental measurements. The present morphological data base and micro-structural model lead to a better understanding of biomechanics of muscular vessels.

Keywords

Biaxial Constitutive Model; Cell Deformation; Morphology; Vascular Smooth Muscle Cell

Conflicts of Interest

The authors declare no conflicts of interest.

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