Stochastic Modelling of Relative Light Sensitivity of Hair Follicles

Ilja L. Kruglikov

Wellcomet GmbH, Karlsruhe, Germany.

DOI: 10.4236/ojbiphy.2013.33024                

Abstract

Relative light sensitivity (RLS) of HFs was mathematically described as the ratio of two stochastic variables presenting the durations of light sensitive and light insensitive sub-phases of the cycle according to a new theory of HF light sensitivity formulated in our previous article (Kruglikov, Am J Cosm Surg, 2012, 29:266 - 272). RLS gives possibility to rank the HFs from different body regions according to their light sensitivities. Application of proposed method for estimation of the light sensitivity of scalp hairs predicts remarkable difference in light sensitivities of HFs in alopecic and non-alopecic patients.

Keywords

Light Sensitivity; Hair Follicle; Mathematical Model

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	I. L. Kruglikov, “Melanin Light Absorption is the Necessary but Not the Sufficient Condition for the Photoepilation: Heterogeneous Light Sensitivity of Anagen SubPhases,” The American Journal of Cosmetic Surgery, Vol. 29, No. 4, 2012, pp. 266-272.
[2]	I. L. Kruglikov, “Melanin Light Absorption is the Necessary but Not the Sufficient Condition for the Photoepilation: Miniaturisation and Eclipse Phenomena,” The American Journal of Cosmetic Surgery, Vol. 30, No. 1, 2013, pp. 21-27.
[3]	V. Kolinko and C. M. Littler, “Mathematical Modelling for the Prediction and Optimization of Laser Hair Removal,” Lasers in Surgery and Medicine, Vol. 26, No. 2, 2000, pp. 164-176. doi:10.1002/(SICI)1096-9101(2000)26:2<164::AID-LSM7>3.0.CO;2-W
[4]	J. Halloy, B. A. Bernard, G. Loussouarn and A. Goldbeter, “Modelling the Dynamics of Human Hair Cycles by a Follicular Automation,” Proceedings of the National Academy of Sciences, Vol. 97, No. 15, 2000, pp. 8328-8333. doi:10.1073/pnas.97.15.8328
[5]	J. Halloy, B. A. Bernard, G. Loussouarn and A. Goldbeter, “The Follicular Automation Model: Effect of Stochasticity and Synchronization of Hair Cycles,” Journal of Theoretical Biology, Vol. 214, No. 3, 2002, pp. 469-479. doi:10.1006/jtbi.2001.2474
[6]	R. N. Richards, M. Uy and G. Meharg, “Temporary Hair Removal in Patients with Hirsutism: A Clinical Study,” Cutis, Vol. 45, No. 3, 1990, pp. 199-202.
[7]	M. Saitoh, M. Uzuka and M. Sakamoto, “Human Hair Cycle,” Journal of Investigative Dermatology, Vol. 54, No. 1, 1970, pp. 65-81. doi:10.1111/1523-1747.ep12551679
[8]	K. S. Stenn and R. Paus, “Controls of Hair Follicle Cycling,” Physiological Reviews, Vol. 81, 2001, pp. 449-494.
[9]	M. Courtois, G. Loussouarn, C. Hourseau and J. F. Grollier, “Hair Cycle and Alopecia,” Skin Pharmacology, Vol. 7, No. 1, 1994, pp. 84-89. doi:10.1159/000211279
[10]	M. Courtois, G. Loussouarn, C. Hourseau and J. F. Grollier, “Ageing and Hair Cycles,” British Journal of Dermatology, Vol. 132, No. 1, 1995, pp. 86-93. doi:10.1111/j.1365-2133.1995.tb08630.x
[11]	M. Courtois, G. Loussouarn, C. Hourseau and J. F. Grollier, “Periodicity in the Growth and Shedding of Hair,” British Journal of Dermatology, Vol. 134, No. 1, 1995, pp. 47-54. doi:10.1111/j.1365-2133.1996.tb07839.x