Short Report of a Preliminary Open Study of Synofit-Containing Bio-Curcumin, Greenlipped Mussel and Blackcurrant Leaf Extract in Arthritis


To evaluate the potential benefit of Synofit—an association of Curcumin, Perna canaliculus green-mussels and blackcurrant leaf extracts, a real life open study was performed among 86 adult out patients suffering from Fibromyalgia (n = 22), low back pain (n = 33) or knee osteoarthritis (n = 31) who accepted to take 3 tablets a day during 1 week then 2 capsules of Synofit during 2 months in addition to their conventional therapy (mainly analgesics and anti-inflammatory) and then to report their evaluation of this complementary treatment. Statistical analysis included paired t test and when possible Wilcoxon signed rank test. Accordingly, the intermediate analysis showed that already within 4 weeks of treatment, an improvement quoted as “light” was statistically reported in patients with low back pain and knee osteoarthritis but not among those with fibromyalgia on pain, physical condition, global assessment of a benefit, quality of life but not on joint stiffness (although joint stiffness considered for the whole group was statistically improved). The limited number of patients and time duration of the study and the absence of double blind controlled study do not allow concluding on the efficacy but these preliminary analyses obtained from an intermediate analysis are encouraging for further studies.

Share and Cite:

Qu, J. , Mélot, C. and Appelboom, T. (2015) Short Report of a Preliminary Open Study of Synofit-Containing Bio-Curcumin, Greenlipped Mussel and Blackcurrant Leaf Extract in Arthritis. Open Journal of Rheumatology and Autoimmune Diseases, 5, 113-117. doi: 10.4236/ojra.2015.54018.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Leong, D.J., Choudhury, M., Hirsh, D., Hardin, J., Cobelle, N. and Sun, H. (2013) Neutraceuticals: Potential for Chondroprotection and Molecular Targeting of Osteoarthritis. International Journal of Molecular Sciences, 14, 23063- 23085.
[2] Lawnence, R., Felson, D., Helmid, C., et al. (2008) Estimates of the Prevalence of Arthritis and Other Rheumatic Conditions in the United States. Arthritis & Rheumatology, 58, 26-35.
[3] Aggarwal, B. and Harikumar, K. (2009) Potential Therapeutic Effects of Curcumin, the Anti-Inflammatory Agent against Neurodegenerative, Cardiovascular, Pulmonary, Metabolic, Auto-Immune and Neoplastic Diseases. Interna- tional Journal of Biochemistry & Cell Biology, 41, 40-59.
[4] Pinsorrnsak, P. and Niempoog, S. (2012) The Efficacy of Curcuma Longa l Extract as an Adjuvant Therapy in Primary Knee Osteoarthritis, a Randomized Control Trial. Journal of the Medical Association of Thailand, 95, 51-58.
[5] Brien, S., Prescott, P., Coghlan, B., Bashir, N. and Lewith, G. (2008) Systematic Review of the Nutritional Supplement Perna canaliculus in the Treatment of Osteoarthritis. QJM: An International Journal of Medicine, 101, 167-179.
[6] Miller, M.R., Pearce, L. and Bettjeman, B.I. (2014) Detailed Distribution of Lipids in Greenshell Mussel (Perna canaliculus). Nutriments, 6, 1454-1474.
[7] Doggrel, S. (2011) Review Article: Lyprinol: Is It a Useful Anti-Inflammatory Agent? Evidence-Based Complemen- tary and Alternative Medicine, 2011, Article ID: 307121.
[8] Kuptniratsaikul, V., Dajpratham, P., Taechaarpomkul, W., et al. (2014) Efficacy and Safety of Curcuma Domestica Extracts Compared with Ibuprofen in Patients with Knee Osteoarthritis; a Multicenter Study. Clinical Interventions in Aging, 9, 451-458.
[9] Coulson, S., Butt, H., Vecchio, P., Gramotnev, H. and Vitetta, L. (2013) Green Lipped Mussel Extract (Perna canali- culus) and Glucosamine Sulphate in Patients with Osteoarthritis: Therapeutic Efficacy and Effects on Gastrointestinal Microbiota Profiles. Inflammopharmacology, 21, 79-90.
[10] Mickelborough, T.D., Sinex, J.A., Platt, D., Chapman, R.F. and Hirt, M. (2015) The Effect PCSO-524 a Patented Marine Oil Lipid and Omega-3 PUFA (Perna canaliculus) on Indirect Markers of Muscle Damage and Inflammation after Muscle Damaging Exercise in Untrained Men; a Randomized Placebo Controlled Trial. Journal of the Inter- national Society of Sports Nutrition, 12, 10.

Copyright © 2022 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.