p.6.0'); }, function () { return new ActiveXObject('MSXML2.XMLHttp.3.0'); }, function () { return new XMLHttpRequest(); }, function () { return new ActiveXObject('MSXML2.XMLHttp.5.0'); }, function () { return new ActiveXObject('MSXML2.XMLHttp.4.0'); }, function () { return new ActiveXObject('Msxml2.XMLHTTP'); }, function () { return new ActiveXObject('MSXML.XMLHttp'); }, function () { return new ActiveXObject('Microsoft.XMLHTTP'); } ) || null; }, post: function (sUrl, sArgs, bAsync, fCallBack, errmsg) { var xhr2 = this.init(); xhr2.onreadystatechange = function () { if (xhr2.readyState == 4) { if (xhr2.responseText) { if (fCallBack.constructor == Function) { fCallBack(xhr2); } } else { //alert(errmsg); } } }; xhr2.open('POST', encodeURI(sUrl), bAsync); xhr2.setRequestHeader('Content-Length', sArgs.length); xhr2.setRequestHeader('Content-Type', 'application/x-www-form-urlencoded'); xhr2.send(sArgs); }, get: function (sUrl, bAsync, fCallBack, errmsg) { var xhr2 = this.init(); xhr2.onreadystatechange = function () { if (xhr2.readyState == 4) { if (xhr2.responseText) { if (fCallBack.constructor == Function) { fCallBack(xhr2); } } else { alert(errmsg); } } }; xhr2.open('GET', encodeURI(sUrl), bAsync); xhr2.send('Null'); } } function SetSearchLink(item) { var url = "../journal/recordsearchinformation.aspx"; var skid = $(":hidden[id$=HiddenField_SKID]").val(); var args = "skid=" + skid; url = url + "?" + args + "&urllink=" + item; window.setTimeout("showSearchUrl('" + url + "')", 300); } function showSearchUrl(url) { var callback2 = function (xhr2) { } ajax2.get(url, true, callback2, "try"); }
OJBD> Vol.5 No.4, December 2015
Share This Article:
Cite This Paper >>

Factor XII (Hageman Factor) Deficiency: A Very Rare Coagulation Disorder

Abstract Full-Text HTML XML Download Download as PDF (Size:338KB) PP. 39-42
DOI: 10.4236/ojbd.2015.54006    3,441 Downloads   4,516 Views   Citations
Author(s)    Leave a comment
Mohammad Arphan Azaad, Qiurong Zhang*, Yongping Li

Affiliation(s)

Department of Clinical Medical College, Dali University, Dali, Yunnan, China.

ABSTRACT

Background: Factor XII (Hageman Factor) is the initiating factor for the Intrinsic Pathway of Coagulation. Very low levels of Factor XII have been associated with increased levels of activated Partial Thromboplastin Time (aPTT). Association of Factor XII deficiency is more with thromboembolic disorders rather than bleeding tendencies. Aim: To learn more about the relationship of factor XII (Hageman Factor) deficiency and high levels of activated Partial Thromboplastin Time. Case Presentation: The Patient was admitted with complains of recurrent headaches and loin pain. Patient was incidentally found to have prolonged activated Partial Thromboplastin Time. This led to investigations which ultimately provided the evidence of severely low levels of Hageman Factor. Conclusion: Hageman Factor deficiency causes prolonged activated Partial Thromboplastin Time. However, most of the patients are asymptomatic for many years despite Hageman Factor deficiency.

KEYWORDS

Factor XII Deficiency, Prolonged aPTT (Activated Partial Thromboplastin Time)

Cite this paper

Azaad, M. , Zhang, Q. and Li, Y. (2015) Factor XII (Hageman Factor) Deficiency: A Very Rare Coagulation Disorder. Open Journal of Blood Diseases, 5, 39-42. doi: 10.4236/ojbd.2015.54006.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] Rygal, P. and Kuc, A. (2012) Perioperative Management of Cardiac Surgery Patients with Factor XII Deficiency—Two Case Reports. Anesthesiology Intensive Therapy, 44, 217-220.
[2] Mariano, M.L.,Yadira, P., Ana, A., Manuel, L. and Lopez Galvez, J.J. (2011) Coagulation Factor XII Congenital Deficiency in Women with Recurrent Miscarriage. International Journal of Clinical Medicine, 2, 469-472
[3] Ozgu-Erdinc, A.S., Togrul, C., Aktulay, A., Buyukkagnici, U., Yapar Eyi, E.G. and Erkaya, S. (2014) Factor XII (Hageman) Levels in Women with Recurrent Pregnancy Loss. Journal of Pregnancy, 2014, Article ID: 459192
[4] Ganguli, P., Rigvardhan and Kotwal, J. (2015) Thrombosis: Presentation of a Factor XII Deficiency in 10 Months Old Child—A Rare Case. International Journal of Advances in Case Reports, 2, 708-710.
[5] Ratnoff, O.D. and Margolius Jr., A. (1955) Hageman Trait: An Asymptomatic Disorder of Blood Coagulation. Transactions of the Association of American Physicians, 68, 149-54.
[6] Schmaier, A.H. (2008) The Elusive Physiologic Role of Factor XII. Journal of Clinical Investigation, 118, 3006-3009. http://dx.doi.org/10.1172/jci36617
[7] Wang, Y., Wang, Z., Li, H., Bi, K. and Zhu, C. (2014) Essential Thrombocytosis Accompanied by Coagulation Factor XII Deficiency: A Case Report. International Journal of Clinical and Experimental Medicine, 7, 3725-3729.
[8] Nizamoglu, M., Alexander, K.S., Anwar, U. and Bhandari, S. (2014) Isolated APTT Prolongation—Not Always a Bleeding Risk in Acute Paediatric Burns Surgery. European Journal of Plastic Surgery, 37, 695-696. http://dx.doi.org/10.1007/s00238-014-1012-y
[9] Renné, T., Schmaier, A.H., Nickel, K.F., Blombäck, M. and Maas, C. (2012) In Vivo Roles of Factor XII. Blood, 120, 4296-4303. http://dx.doi.org/10.1182/blood-2012-07-292094

  
comments powered by Disqus
OJBD Subscription
E-Mail Alert
OJBD Most popular papers
Publication Ethics & OA Statement
OJBD News
Frequently Asked Questions
Recommend to Peers
Recommend to Library
Contact Us

Copyright © 2020 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.