Use of Mesenchymal Stem Cells to Grow Cartilage and Bone

Hosseyn Rafei^*

Department of Biology, Faculty of Sciences, Islamic Azad University of Shiraz, Shiraz, Iran.

DOI: 10.4236/jct.2015.66056                

Abstract

Regardless of the fact that bones have a tremendous capacity to be repaired, there are various clinical situations where allographs seek to enhance the regeneration of bones through promotion of osteogenesis [1]. Precarious botches linked to the present grafting treatments include osteonecrosis along with restricted combination between the grafted and host tissues. It is considered that the fundamental issue with the present approaches to bone grafting is the fact that they lead to bone regeneration by means of direct osteogenesis. Therefore, it may be hypothesized that the use of cartilage in the promotion of endochondral regeneration of bones may leverage normal development and repair sequences resulting in a properly vascularized regenerate capable of integrating with the host tissues. Various tests have demonstrated that cartilage grafts are able to support the regeneration of vascularized and integrated bone tissues in vivo, while lineage tracing experiments have revealed graft derived regenerates.

Keywords

Mesenchymal Stem Cells, Cartilage, Bone, Embryonic Sources

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	Ozkaya, N. and Ozkaya, N. (2012) Fundamentals of Biomechanics. Springer, New York. http://dx.doi.org/10.1007/978-1-4614-1150-5
[2]	Nolta, J. (2006) Genetic Engineering of Mesenchymal Stem Cells. Springer, Dordrecht. http://dx.doi.org/10.1007/1-4020-3959-X
[3]	Cech, D. and Martin, S. (2012) Functional Movement Development across the Life Span. Saunders, St. Louis.
[4]	Laughlin, M. and Lazarus, H. (2010) Allogeneic Stem Cell Transplantation. Humana Press, Totowa.
[5]	Khurana, J. (2009) Bone Pathology. Humana Press, Dordrecht. http://dx.doi.org/10.1007/978-1-59745-347-9
[6]	Dib, N., Taylor, D. and Diethrich, E. (2006) Stem Cell Therapy and Tissue Engineering for Cardiovascular Repair. Springer, New York. http://dx.doi.org/10.1007/0-387-30939-X
[7]	Turksen, K. (2012) Adult and Embryonic Stem Cells. Humana Press, New York. http://dx.doi.org/10.1007/978-1-61779-630-2
[8]	Sorensen, M. (2008) Stem Cell Applications in Diseases. Nova Biomedical Books, New York.
[9]	Fisher, J. (2013) Tissue Engineering. CRC Press, Boca Raton.