The molecular mechanism for DDT detoxification in Anopheles gambiae: A molecular docking study


The epsilon class glutathione-S-transferase of Anopheles gambiae, agGSTe2, is capable of metabolizing DDT. A molecular docking analysis of DDT with agGSTe2 support an E2 elimination mechanism wherein the glutathione sulfur serves as the base to convert DDT to DDE.

Share and Cite:

Setzer, W. (2011) The molecular mechanism for DDT detoxification in Anopheles gambiae: A molecular docking study. Journal of Biophysical Chemistry, 2, 135-136. doi: 10.4236/jbpc.2011.22016.

Conflicts of Interest

The authors declare no conflicts of interest.


[1] Breman, J.G., Alilio, M.S. and White, N.J. (2007) Defining and defeating the intolerable burden of malaria III. Progress and perspectives. American Journal of Tropical Medicine and Hygiene, 77, 6-11.
[2] Rowe, A.K., Rowe, S.Y., Snow, R.W., Korenromp, E.I., Armstrong Schellenberg, J.R.M., Stein, C., Nahlen, B.L., Bryce, J., Black, R.E. and Steketee, R.W. (2006) The burden of malaria mortality among African children in the year 2000. International Journal of Epidemiology, 35, 691-704. doi:10.1093/ije/dyl027
[3] Bruce-Chwatt, L.J. (1987) Malaria and its control: Present situation and future prospects. Annual Review of Public Health, 8, 75-110. doi:10.1146/annurev.pu.08.050187.000451
[4] Bradley, D.J. (1998) The particular and the general: Issues of specificity and verticality in the history of malaria control. Parassitologia, 40, 5-10.
[5] Hayes, J.D. and Pulford, D.J. (1995) The glutathione S-transferase supergene family: Regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Critical Reviews in Biochemistry and Molecular Biology, 30, 445-600. doi:10.3109/10409239509083491
[6] Ranson, H., Prapanthadara, L. and Hemingway, J. (1997) Cloning and characterization of two glutathione S-transferases from a DDT-resistant strain of Anopheles gambiae. Biochemical Journal, 324, 97-102.
[7] Ranson, H., Rossiter, L., Ortelli, F., Jensen, B., Wang, X., Roth, C.W., Collins, F.H. and Hemingway, J. (2001) Identification of a novel class of insect glutathione S-transferases involved in resistance to DDT in the malaria vector Anopheles gambiae. Biochemical Journal, 359, 295-304. doi:10.1042/0264-6021:3590295
[8] Wang, Y., Qiu, L., Ranson, J., Lumjuan, N., Hemingway, J., Setzer, W.N., Meehan, E.J. and Chen, L. (2008) Structure of an insect epsilon class glutathione S-transferase from the malaria vector Anopheles gambiae provides an explanation for the high DDT-detoxifying activity. Journal of Structural Biology, 164, 228-235. doi:10.1016/j.jsb.2008.08.003
[9] Molegro Virtual Docker, Version 3.2.1. (2009) Molegro ApS, Aarhus, Denmark.
[10] Thomsen, R. and Christensen, M.H. (2006) MolDock: A new technique for high-accuracy molecular docking. Journal of Medicinal Chemistry, 49, 3315-3321. doi:10.1021/jm051197e

Copyright © 2021 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.