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A Review on the Biology of Cancer Stem Cells

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DOI: 10.4236/scd.2014.44009    6,043 Downloads   10,128 Views   Citations

ABSTRACT

Cancer Stem Cells (CSC) have the ability to self-renew and are present in most tissues including breast, brain, lung, prostates, testis, ovary, esophagus, colon, and liver. Their origin is yet to be discovered, though a series of hypotheses have been proposed in this regard. CSCs play a role in not only the creation of cancer, but also in its evolution, metastasis, and recurrence. CSCs have an important role in cancer therapy and the resistance towards chemotherapeutic agents. This article reviews the characteristics of cancer stem cells in terms of origin, resistance towards chemotherapy, methods of isolation, and cancer therapy.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Atena, M. , Reza, A. and Mehran, G. (2014) A Review on the Biology of Cancer Stem Cells. Stem Cell Discovery, 4, 83-89. doi: 10.4236/scd.2014.44009.

References

[1] Bjerkvig, R., Tysnes, B.B., Aboody, K.S., Najbauer, J. and Terzis, A.J. (2005) Opinion: The Origin of the Cancer Stem Cell: Current Controversies and New Insights. Nature Reviews Cancer, 5, 899-904.
[2] Soltanian, S. and Matin, M.M. (2012) Cancer Stem Cells and Cancer Therapy. Tumor Biology, 32, 425-440.
[3] Huntly, B.J. and Gilliland, D.G. (2005) Leukaemia Stem Cells and the Evolution of Cancer-Stem-Cell Research. Nature Reviews Cancer, 5, 311-321. http://dx.doi.org/10.1038/nrc1592
[4] Bonnet, D. and Dick, J.E. (1997) Human Acute Myeloid Leukemia Is Organized as a Hierarchy That Originates from a Primitive Hematopoietic Cell. Nature Medicine, 7, 730-737.
[5] Lapidot, T., et al. (1994) A Cell Initiating Human Acute Myeloid Leukaemia after Transplantation into SCID Mice. Nature, 367, 645-648.
[6] Cammareri, P., Lombardo, Y., Francipane, M.G., Bonventre, S., Todaro, M. and Stassi, G. (2008) Isolation and Culture of Colon Cancer Stem Cells. Methods in Cell Biology, 311-324.
[7] O’Brien, C.A., Pollett, A., Gallinger, S. and Dick, J.E. (2007) A Human Colon Cancer Cell Capable of Initiating Tumour Growth in Immunodeficient Mice. Nature, 445, 106-110.
[8] Ischenko, I., Seeliger, H., Jauch, K.W. and Bruns, C.J. (2009) Metastatic Activity and Chemotherapy Resistance in Human Pancreatic Cancer—Influence of Cancer Stem Cells. Surgery, 146, 430-434.
[9] Ouhtit, A., Abd Elmageed, Z.Y., Abdraboh, M.E., Lioe, T.F. and Raj, M.H.G. (2007) In Vivo Evidence for the Role of CD44s in Promoting Breast Cancer Metastasis to the Liver. The American Journal of Pathology, 171, 2033-2039.
[10] Maenhaut, C., Dumont, J.E., Roger, P.P. and van Staveren, W.C. (2010) Cancer Stem Cells: A Reality, a Myth, a Fuzzy Concept or a Misnomer? Carcinogenesis, 31, 149-158.
http://dx.doi.org/10.1093/carcin/bgp259
[11] Patrawala, L., Calhoun, T., Schneider-Broussard, R., Li, H., Bhatia, B., Tang, S., Reilly, J.G., Chandra, D., Zhou, J., Claypool, K., Coghlan, L. and Tang, D.G. (2006) Highly Purified CD44+ Prostate Cancer Cells from Xenograft Human Tumors Are Enriched in Tumorigenic and Metastatic Progenitor Cells. Oncogene, 25, 1696-1708. http://dx.doi.org/10.1038/sj.onc.1209327
[12] Al-Hajj, M., Wicha, M.S., Benito-Hernandez, A., Morrison, S.J. and Clarke, M.F. (2003) Prospective Identification of Tumorigenic Breast Cancer Cells. Proceedings of the National Academy of Sciences of the United States of America, 100, 3983-3988. http://dx.doi.org/10.1073/pnas.0530291100
[13] Klonisch, T., Wiechec, E., Hombach-Klonisch, S., Ande, S.R., Wesselborg, S., Schulze-Osthoff, K. and Los, M. (2008) Cancer Stem Cell Markers in Common Cancers-Therapeutic Implications. Trends in Molecular Medicine, 14, 450-460. http://dx.doi.org/10.1016/j.molmed.2008.08.003
[14] Singh, S.K., Hawkins, C., Clarke, I.D., Squire, J.A., Bayani, J., Hide, T., Henkelman, R.M., Cusimano, M.D. and Dirks, P.B. (2004) Identification of Human Brain Tumour Initiating Cells. Nature, 432, 396-401. http://dx.doi.org/10.1038/nature03128
[15] Annabi, B., Rojas-Sutterlin, S., Laflamme, C., Lachambre, M.P., Rolland, Y., Sartelet, H. and Beliveau, R. (2008) Tumor Environment Dictates Medulloblastoma Cancer Stem Cell Expression and Invasive Phenotype. Molecular Cancer Research, 6, 907-916. http://dx.doi.org/10.1158/1541-7786.MCR-07-2184
[16] Shien, K., Toyooka, S., Ichimura, K., Soh, J., Furukawa, M., Maki, Y., Muraoka, T., Tanaka, N., Ueno, T., Asano, H., Tsukuda, K., Yamane, M., Oto, T., Kiura, K. and Miyoshi, S. (2012) Prognostic Impact of Cancer Stem Cell-Related Markers in Non-Small Cell Lung Cancer Patients Treated with Induction Chemoradiotherapy. Lung Cancer, 77, 162-167. http://dx.doi.org/10.1016/j.lungcan.2012.02.006
[17] Kure, S., Matsuda, Y., Hagio, M., Ueda, J., Naito, Z. and Ishiwata, T. (2012) Expression of Cancer Stem Cell Markers in Pancreatic Intraepithelial Neoplasias and Pancreatic Ductal Adenocarcinomas. International Journal of Oncology, 41, 1314-1324.
[18] Ricci-Vitiani, L., Lombardi, D.G., Pilozzi, E., Biffoni, M., Todaro, M., Peschle, C. and De Maria, R. (2007) Identification and Expansion of Human Colon-Cancer-Initiating Cells. Nature, 445, 111-115. http://dx.doi.org/10.1038/nature05384
[19] Fang, D., Nguyen, T.K., Leishear, K., Finko, R., Kulp, A.N., Hotz, S., Van Belle, P.A., Xu, X., Elder, D.E. and Herlyn, M. (2005) A Tumorigenic Subpopulation with Stem Cell Properties in Melanomas. Cancer Research, 65, 9328-9337. http://dx.doi.org/10.1158/0008-5472.CAN-05-1343
[20] Boman, B.M. and Wicha, M.S. (2008) Cancer Stem Cells: A Step toward the Cure. Journal of Clinical Oncology, 26, 2795-2799. http://dx.doi.org/10.1200/JCO.2008.17.7436
[21] Bertolini, G., Roz, L., Perego, P., Tortoreto, M., Fontanella, E., Gatti, L., Pratesi, G., Fabbri, A., Andriani, F., Tinelli, S., Roz, E., Caserini, R., Lo Vullo, S., Camerini, T., Mariani, L., Delia, D., Calabro, E., Pastorino, U. and Sozzi, G. (2009) Highly Tumorigenic Lung Cancer CD133+ Cells Display Stem-Like Features and Are Spared by Cisplatin Treatment. Proceedings of the National Academy of Sciences of the United States of America, 106, 16281-16286. http://dx.doi.org/10.1073/pnas.0905653106
[22] Cantley, L.C., Dalton, W.S., DuBois, R.N., Finn, O.J., Futreal, P.A., Golub, T.R., et al. (2012) AACR Cancer Progress Report 2012. Clinical Cancer Research, 18, S1-S100.
http://dx.doi.org/10.1158/1078-0432.CCR-12-2891
[23] Hermann, P.C., Huber, S.L., Herrler, T., Aicher, A., Ellwart, J.W., Guba, M., Bruns, C.J. and Heeschen, C. (2007) Distinct Populations of Cancer Stem Cells Determine Tumor Growth and Metastatic Activity in Human Pancreatic Cancer. Cell Stem Cell, 1, 313-323.
http://dx.doi.org/10.1016/j.stem.2007.06.002
[24] Wang, Q., Chen, Z.G., Du, C.Z., Wang, H.W., Yan, L. and Gu, J. (2009) Cancer Stem Cell Marker CD133+ Tumour Cells and Clinical Outcome in Rectal Cancer. Histopathology, 55, 284-293. http://dx.doi.org/10.1111/j.1365-2559.2009.03378.x
[25] Stassi, G., Todaro, M., Zerilli, M., Ricci-Vitiani, L., Di Liberto, D., Patti, M., Florena, A., Di Gaudio, F., Di Gesù, G. and De Maria, R. (2003) Thyroid Cancer Resistance to Chemotherapeutic Drugs via Autocrine Production of Interleukin-4 and Interleukin-10. Cancer Research, 63, 6784-6790.
[26] Dancescu, M., RubioTrujillo, M., Biron, G., Bron, D., Delespesse, G. and Sarfati, M. (1992) Interleukin 4 Protects Chronic Lymphocytic Leukemic B Cells from Death by Apoptosis and Upregulates Bcl-2 Expression. Journal of Experimental Medicine, 176, 1319-1326.
http://dx.doi.org/10.1084/jem.176.5.1319
[27] Rich, J.N. and Bao, S.D. (2007) Chemotherapy and Cancer Stem Cells. Cell Stem Cell, 1, 353-355. http://dx.doi.org/10.1016/j.stem.2007.09.011
[28] Chuthapisith, S. (2011) Cancer Stem Cells and Chemoresistance. InTech, Shanghai.
[29] Signore, M., Ricci-Vitiani, L. and De Maria, R. (2013) Targeting Apoptosis Pathways in Cancer Stem Cells. Cancer Letters, 332, 374-382. http://dx.doi.org/10.1016/j.canlet.2011.01.013
[30] Avenda?o, C. and Menéndez, J.C. (2002) Inhibitors of Multidrug Resistance to Antitumor Agents (MDR). Current Medicinal Chemistry, 9, 159-193. http://dx.doi.org/10.2174/0929867023371175
[31] Takaishi, S., Okumura, T., Tu, S.P., Wang, S.S.W., Shibata, W., Vigneshwaran, R., et al. (2009) Identification of Gastric Cancer Stem Cells Using the Cell Surface Marker CD44. Stem Cells, 27, 1006-1020. http://dx.doi.org/10.1002/stem.30
[32] Chiou, S.H., Hung, S.C., Kao, C.L., Chen, Y.W., Wong, T.T., Chien, C.S., Lo, J.F., et al. (2008) Identification of CD133-Positive Radioresistant Cells in Atypical Teratoid/Rhabdoid Tumor. PLoS ONE, 3, e2090. http://dx.doi.org/10.1371/journal.pone.0002090
[33] Bao, S., Wu, Q., Sathornsumetee, S., Hao, Y., Li, Z., Hjelmeland, A.B., Shi, Q., McLendon, R.E., Bigner, D.D. and Rich, J.N. (2006) Stem Cell-Like Glioma Cells Promote Tumor Angiogenesis through Vascular Endothelial Growth Factor. Cancer Research, 66, 7843-7848. http://dx.doi.org/10.1158/0008-5472.CAN-06-1010
[34] van Staveren, W.C., Solís, D.Y., Hébrant, A., Detours, V., Dumont, J.E. and Maenhaut, C. (2009) Human Cancer Cell Lines: Experimental Models for Cancer Cells in Situ? For Cancer Stem Cells? Biochimica et Biophysica Acta, 1795, 92-103.
[35] Lee, J., Kotliarova, S., Kotliarov, Y., Li, A.G., Su, Q., Donin, N.M., et al. (2006) Tumor Stem Cells Derived from Glioblastomas Cultured in bFGF and EGF More Closely Mirror the Phenotype and Genotype of Primary Tumors than Do Serum-Cultured Cell Lines. Cancer Cell, 9, 391-403. http://dx.doi.org/10.1016/j.ccr.2006.03.030
[36] Koch, U., Krause, M. and Baumann, M. (2010) Cancer Stem Cells at the Crossroads of Current Cancer Therapy Failures-Radiation Oncology Perspective. Seminars in Cancer Biology, 20, 116-124. http://dx.doi.org/10.1016/j.semcancer.2010.02.003

  
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