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Melatonin changes the electrical spontaneous activity of hippocampal rat neurons at different ages

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DOI: 10.4236/aar.2014.31006    3,215 Downloads   5,193 Views   Citations


Melatonin, the pineal indole is characterized by being a compound that crosses all cell membranes and which has been attributed to several mechanisms of action. Among these it is the ability to reduce free radicals, thereby reducing the potential aging and cell death. Studies in different age Wistar rats have shown that chronic application of melatonin, in the hippocampus, reduces the concentration of free radicals and keeps its architecture. This study showed that melatonin increases the firing rate and favors the presence of bursting activity in animals of different ages. It is suggested that melatonin conserved hippocampal cells in good anatomical and physiological condition probably as a result of the elimination of free radicals.

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The authors declare no conflicts of interest.

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Perez-Torres, D. , Reyes-Vázquez, C. , Velázquez-Paniagua, M. and rieto-Gómez, B. (2014) Melatonin changes the electrical spontaneous activity of hippocampal rat neurons at different ages. Advances in Aging Research, 3, 29-34. doi: 10.4236/aar.2014.31006.


[1] López, L.C., Escames, G., López, A. and García, J.A. Doerrier, C. and Acuna-Castroviejo, D. (2010) Melatonin, neurogenesis, and aging brain. The Open Neuroendocrinology Journal, 3, 121-133.
[2] Rameswhar, S. and Sharma, D. (2005) Electrophysiology ageing of the brain and pharmacology of ageing. In: Thakur, M.K. and Prasad, S., Eds., Molecular and Cellular Neurobiology, Narosa Publishing House Pvt. Ltd., New Delhi, 135-148.
[3] Peters, R. (2006) Ageing and the brain. Postgraduate Medical Journal, 82, 84-88.
[4] Anderson, B.H. (2002) Ageing of the brain. Mechanisms of Ageing and Development, 123, 811-817.
[5] Rosenzweig, E.S. and Barnes, C.A. (2003) Impact of aging on hippocampal function: plasticity, network dynamic, and cognition. Progress in Neurobiology, 69, 143179.
[6] Gallagher, M. (1997) The use of animal models to study the effects of aging on cognition. Annual Review of Psychology, 48, 339-370.
[7] Small, S.A., Schobel, S.A., Buxton, R.B., Witter, M.P. and Barnes, C.A. (2011) A pathophysiological framework of hippocampal dysfunction in ageing and disease. Nature Reviews Neuroscience, 12, 585-601.
[8] Jessberger, S. and Gage, F.H. (2008) Stem-cell-associated structural and functional plasticity in the aging hippocampus. Psychology and Aging, 23, 684-691.
[9] Dickstein, D.L. Weaver C.M., Luebke, J.I. and Hof, P.R. (2013) Dendritic spine changes associated with normal aging. Neuroscience, 22, 21-32.
[10] Burke, S.N. and Barnes, C.A. (2010) Senescent synapses and hippocampal circuit dynamics. Trends in Neurosciences, 33, 153-161.
[11] Srinivasan, V., Pandi-Perumal, S.R., Cardinali, D.P., Poeggeler, B. and Hardeland, R. (2006) Melatonin in Alzheimer’s disease and other neurodegenerative disorders. Behavioral and Brain Functions, 4, 2-15.
[12] Escames, G., López, A., García, J.A., García, L., AcunaCastroviejo, D., García, J.J. and López, L.C. (2010) The role of mitochondria in brain aging and the effects of melatonin. Current Neuropharmacology, 8, 182-193.
[13] Reiter, R.J., Melchiorri, D., Sewerynek, E., Poeggeler, B., Barlow-Walden, L., Chuang, J., Ortiz, G.G. and AcunaCastroviejo, D. (1995) A review of the evidence supporting melatonin’s role as an antioxidant. Journal of Pineal Research, 18, 1-11.
[14] Tomás-Zapico, C. and Coto-Montes, A. (2007) Melatonin as antioxidant under pathological processes. Recent Patents on Endocrine, Metabolic & Immune Drug Discovery, 1, 63-82.
[15] Ozcan, M., Yilmaz, B. and Carpenter, D.O. (2006) Effects of melatonin on synaptic trasmission and long-term potentiation in two areas of mouse hippocampus. Brain Research, 1111, 90-94.
[16] Chawla, S.L. and Rao, M.V. (2012) Protective effect of melatonin against fluorideinduced oxidative stress in the mouse ovary. Research Report Fluoride, 45, 125-132.
[17] Reiter R.J. and Benitez-King G. (2009) Melatonin reduces neuronal loss and cytoskeletal. Salud Mental, 32, 3-11.
[18] Srinivasan, V., Spence, D.W., Pandi-Perumal, S.R., Brown Gregory, M. and Cardinali Daniel, P. (2011) Melatonin in mitochondrial dysfunction and related disorders. International Journal of Alzheimer’s Disease, 2011, Article ID: 326320.
[19] Gupta, Y.K., Gupta, M. and Kohli, K. (2003) Neuroprotective role of melatonin in oxidative stress vulnerable brain. Indian Journal of Physiology and Pharmacology, 47, 373-386.
[20] Musshoff, U., Riewenherm, D., Berger, E., Fauteck, J.D. and Speckmann, E.J. (2002) Melatonin receptors in rat hippocampues: Molecular and functional investigations. Hippocampus, 12, 165-173.
[21] Dubocovich, M.L., Delagrange, P., Krause, D.N., Sugden, D., Cardinali, D.P. and Olcese, J. (2010) International union of basic and clinical pharmacology. LXXV. Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptors. Pharmacological Reviews, 62, 343-380.
[22] Lee, C.H., Choi, J.H., Yoo, K.Y., Park, O.K., Hwang, I.K., You, S.G., Lee, B.Y., Kang, I.J. and Won, M.H. (2010) MT2 melatonin receptor immunoreactivity in neurons is very high in the aged hippocampal formation in gerbils. Cellular and Molecular Neurobiology, 30, 255-263.
[23] Cavanaugh, J.E. and Witt-Enderby Paul, A. (2010) Mini-review: CNS melatonin receptors and signaling: Focus on aging-related diseases and future perspectives. The Open Neuroendocrinology Journal, 3, 96-104.
[24] Velázquez, P.M, Contreras, P.R., Gómez, V.V., Meneses, M.A. and Prieto, G.B. (2007) Melatonin’s effects on free radical levels in rat hippocampus, measured by electronic paramagnetic resonance. Pharmacologyonline, 1, 170175.
[25] Reiter, R.J., Tan, D.X., Mayo, J.C, Sainz, R.M., Leon, J. and Czarnocki, Z. (2003) Melatonin as an antioxidant: biochemical mechanisms and pathophysiological implications in humans. Acta Biochimica Polonica, 50, 11291146.
[26] Benítez, K.G. (2006) Melatonin as a cytoskeletal modulator: Implications for cell physiology and disease. Journal of Pineal Research, 40, 1-9.
[27] Prieto, G.B., Velázquez, P.M., Olivos, C.L., Reyes, V.C., Jiménez, T.F., Reyes, ME., Mendoza, T.J. and Gutiérrez, O.G. (2008) Melatonin attenuates the decrement of dendritic protein MAP-2 immuno-staining in the hippocampal CA1 and CA3 fields of the aging male rat. Neuroscience Letters, 448, 56-61.
[28] Pellegrino, J.L., Pellegrino, S.A. and Cushman, J.A. (1986) A stereotaxic atlas of the rat brain. Plenum Press, New York, 4-122.
[29] Foster, T.C. (2007) Calcium homeostasis and modulation of synaptic plasticity in aged brain. Aging Cell, 6, 319325.
[30] Poloni, J.F., Feltes, B.C. and Bonatto, D. (2011) Melatonin as a central molecule connecting neural development and calcium signaling. Functional & Integrative Genomics, 11, 383-388.
[31] Wan, Q., Man, H.Y., Liu, F., Braunton, J., Niznik, H.B., Fun, P.S., Brown, G.M. and Wang, Y.T. (1999) Differential modulation of GABAA receptor function by Mel1a and Mel1b receptors. Nature Neuroscience, 2, 401-403.
[32] Luchetti, F., Canonico, B., Betti, M., Ancandeletti, M., Pilolli, F., Piroddi, M., Canesi, L., Papa, S. and Galli, F. (2010) Melatonin signaling and cell protection function. 24, 3603-3624.

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