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The Cerebral Blood Flow Correlates of Emotional Facial Processing in Mild Alzheimer's Disease

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DOI: 10.4236/nm.2011.21002    4,410 Downloads   8,512 Views   Citations

ABSTRACT

Deficits in facial emotion processing are features of mild Alzheimer’s disease (AD). These impairments are often dis-tressing for carers as well as patients. Such non-cognitive symptoms are often cited as a contributing reason for admis-sion into institutionalised care. The ability to interpret emotional cues is crucial to healthy psychological function and relationships and impaired emotional facility may lead to antisocial behavior. Understanding the origins of the non-cognitive aspects of AD may lead to an improvement in the management of sufferers and ease the carer burden. In a cross-sectional study we recorded patients’ facial processing abilities, (emotion and identity recognition) and disease severity (ADAS-cog, Neuropsychiatic Inventory) and investigated the regional cerebral blood flow correlates of facial emotion processing deficits using 99Tcm HMAPO rCBF SPECT. Using statistical parametric mapping (SPM) we iden-tified decreased blood flow in posterior frontal regions specifically associated with emotion perception deficits. Non-emotional facial processing abilities or disease severity. The posterior frontal lobe has been identified in previous stud-ies in the absence of dementia as being important in emotion processing. The results suggest that the cognitive disease severity, in combination with the facial processing ability, do not completely explain facial emotion processing in AD patients and that the posterior frontal lobe mediates such behaviour.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

R. Staff, T. Ahearn, L. Phillips, C. Scott, D. Mowat, C. Wischik, L. Whalley and A. Murray, "The Cerebral Blood Flow Correlates of Emotional Facial Processing in Mild Alzheimer's Disease," Neuroscience and Medicine, Vol. 2 No. 1, 2011, pp. 6-13. doi: 10.4236/nm.2011.21002.

References

[1] J. Keane, A. J. Calder, J. R. Hodges and A. W. Young. “Face and Emotion Processing in Frontal Variant Frontotemporal Dementia.” Neuropsychologia, Vol. 40, No. 2, 2002, pp. 655-65. doi:10.1016/S0028-3932(01)00156-7
[2] L. Brosgole, J. Kurucz, T. J. Plahovinsak, C. Spr-otte and Y. A. Haveliwala. “Facial-Affect and Postural-Affect Recognition in Senile Elderly Persons.” International Journal of Neurosciences, Vol. 22, No. 1-2, 1983, pp.37-45. doi:10.3109/00207459308987383
[3] S. E. Starkstein, S. Vazquez, G. Petracca, L. Sabe, R. Migliorelli, A. Teson and R. Leiguarda. “A Spect Study of Delusions in Alzheimers-Disease.” Neurology, Vol. 44, No. 11, 1994, pp. 2055-2059.
[4] B. M. Depaulo. “Nonverbal Behavior and Self-Presentation,” PsycholBull, Vol. 111, 1992, pp. 203-243. doi:10.1037/0033-2909.111.2.203
[5] J. S. Carton, E. A. Kessler and C. L. Pape. “Nonverbal Decoding Skills and Relationship Well-Being in Adults.” Journal of Nonverbal Behavior, Vol. 23, 1999, pp. 91-100. doi:10.1023/A:1021339410262
[6] T. Hope, J. Keene, C. G. Fairburn, R. Jacoby and R. McShane. “Natural History of Behavioural Changes and Psychiatric Symptoms in Alzheimer's Disease: A Longitudinal Study,” British Journal of Psychiatry, Vol. 174, 1999, pp. 39-44. doi:10.1192/bjp.174.1.39
[7] K. L. Phan, T. Wager, S. F. Taylor and I. Liberzon. “Functional Neuroanatomy of Emotion: A Meta-Analysis of Emotion Activation Studies in PET and fMRI,” Neuroimage, Vol. 16, No.2, 2002, pp. 331-48. doi:10.1006/nimg.2002.1087
[8] D. Horinek, A. Varjassyova and J. Hort. “Magnetic Resonance Analysis of Amygdalar Volume in Alzheimer's Disease,” Current Opinion in Psychiatry, Vol. 20, 2007, pp. 273-7.
[9] R. Adolphs, H. Damasio, D. Tranel and A. R. Damasio. “Cortical Systems for the Recognition of Emotion in Facial Expressions,” Journal of Neuroscience, Vol. 16, 1996, pp. 7678-87.
[10] A. K. Anderson, D. D. Spencer, R. K. Fulbright and E. A. Phelps. “Contribution of the Anteromedial Temporal Lobes to the Evaluation of Facial Emotion,” Neuropsychology, Vol. 14, 2000, pp. 526-36. doi:10.1037/0894-4105.14.4.526
[11] J. C. Borod, B. A. Cicero, L. K. Obler, J. Welkowitz, H. M. Erhan, C. Santschi, I. S. Grunwald, R. M. Agosti and J. R. Whalen, “Right Hemisphere Emotional Perception: Evidence across Multiple Channels,” Neuropsychology, Vol. 12, 1998, pp. 446-58. doi:10.1037/0894-4105.12.3.446
[12] H. J. Rosen, M. R. Wilson, G. F. Schauer, S. Allison, M. L. Gorno-Tempini, C. Pace-Savitsky, J. H. Kramer, R. W. Levenson, M. Weiner and B. L. Miller. “Neuroanatomical Correlates of Impaired Recognition of Emotion in Dementia,” Neuropsychologia, Vol. 44, 2006, pp. 365-373. doi:10.1016/j.neuropsychologia.2005.06.012
[13] A. Shimokawa, N. Yatomi, S. Anamizu, I. Ashikari, M. Kohno, Y. Maki, S. Torii, H. Isono, Y. Sugai, N. Koyama and Y. Matsuno, “Comprehension of Emotions: Comparison between Alzheimer Type and Vascular Type Dementias,” Dement Geriatr Cogn Disord , Vol. 11, 2000, pp. 268-74. doi:10.1159/000017249
[14] M. S. Albert, C. Cohen and E. Koff. “Perception of Affect in Patients with Dementia of the Alzheimer Type.” Archives of Neurology, Vol. 48, 1991, pp. 791-795.
[15] E. Koff, D. Zaitchik, J. Montepare and M. S. Albert, “Emotion Processing in the Visual and Auditory Domains by Patients with Alzheimer's Disease,” Journal of the International Neuropsychological Society , Vol. 5, 1999, pp. 32-40. doi:10.1017/S1355617799511053
[16] H. J. Rosen, R. J. Perry, J. Murphy, J. H. Kramer, P. Mychack, N. Schuff, M. Weiner, R. W. Levenson and B. L. Miller, “Emotion Comprehension in the Temporal Variant of Frontotemporal Dementia,” Brain, Vol. 125, 2002, pp. 2286-2295. doi:10.1093/brain/awf225
[17] H. J. Rosen, K. Pace-Savitsky, R. J. Perry, J. H. Kramer, B. L. Miller and R. W. Levenson, “Recognition of Emotion in the Frontal and Temporal Variants of Frontotemporal Dementia,” Dement Geriatr Cogn Disord, Vol. 17,2004, pp. 277-81. doi:10.1159/000077154
[18] D. Wyper, E. Teasdale, J. Patterson, D. Montaldi, D. Brown, R. Hunter, D. Graham and J. Mcculloch. “Abnormalities in Rcbf and Computed-Tomography in Patients with Alzheimers-Disease and in Controls,” British Journal of Radiology, Vol. 66, 1993, pp. 23-27. doi:10.1259/0007-1285-66-781-23
[19] R. T. Staff, M. F. Shanks, L. Macintosh, S. J. Pestell, H. G. Gemmell and A. Venneri, “Delusions in Alzheimer’s Disease: SPET Evidence of Right Hemispheric Dysfunction.” Cortex, Vol. 35,1999, pp. 549-60. doi:10.1016/S0010-9452(08)70818-9
[20] P. H. Robert, G. Darcourt, M. P. Koulibaly, S. Clairet, M. Benoit, R. Garcia, O. Dechaux and J. Darcourt. “Lack of Initiative and Interest in Alzheimer's Disease: A Single Photon Emission Computed Tomography Study,” European Journal of Neurology, Vol. 13, 2006, pp. 729-35. doi:10.1111/j.1468-1331.2006.01088.x
[21] F. Lebert, F. Pasquier, M. Steinling and H. Petit. “Affective-Disorders Related to Spect Patterns in Alzheimers-Disease: A Study of Emotionalism.” International Journal of Geriatric Psychiatry, Vol. 9, 1994, pp. 327-329. doi:10.1002/gps.930090410
[22] I. Le Ber, E. Guedj, A. Gabelle, P. Verpillat, M. Volteau, C. Thomas-Anterion, M. Decousus, D. Hannequin, P. Vera, L. Lacomblez, A. Camuzat, M. Didic, M. Puel, J. Lotterie, V. Golfier, A. Bernard, M. Vercelletto, C. Magne, F. Sellal, I. Namer, B. Michel, J. Pasquier, F. Salachas, J. Bochet, A. Brice, M. Habert, B. Dubois and French Res Network FTD FTD MND, “Demographic, Neurological and Behavioural Characteristics and Brain Perfusion SPECT in Frontal Variant of Frontotemporal Dementia,” Brain, Vol. 129, 2
[23] D. Blacker, M. S. Albert, S. S. Bassett, R. C. P. Go, L. E. Harrell and M. F. Folstein, “Reliability and Validity of Nincds-Adrda Criteria for Alzheimers-Disease - the National-Institute-Of-Mental-Health Genetic Initiative,” Arch Neurology, Vol. 51, 1994, pp. 1198-1204.
[24] P. M. Doraiswamy, F. Bieber, L. Kaiser, K. R. Krishnan, J. ReuningScherer and B. Gulanski, “The Alzheimer's Disease Assessment Scale: Patterns and Predictors of Baseline Cognitive Performance in Multicenter Alzheimer's disease trials,” Neurology, Vol. 48, 1997, pp. 1511-1517.
[25] R. M. Crum, J. C. Anthony, S. S. Bassett and M. F. Folstein, “Population-Based Norms for the Mini-Mental-State-Examination by Age and Educational-Level,” Journal of the American Medical Association, Vol. 269, 1993, pp. 2386-2391. doi:10.1001/jama.269.18.2386
[26] J. L. Cummings, “The Neuropsychiatric Inventory: Assessing Psychopathology in Dementia Patients.” Neurology, Vol. 48, 1997, pp. S10-16.
[27] A.W. Young, C. A. J. Perret, R. Sprengelmeyer, P. Ekman, “Facial Expressions of Emotion: Stimuli and Tests,” (FEEST), Harcourt Assessment, 2002.
[28] A. L. Benton, H. de Ken and N. R. Varney, “Contributions to Neuropsychological Assessment: A Clinical Manual,” 1994.
[29] H. G. Gemmell, P. F. Sharp, F. W. Smith, J. A. O. Besson, K. P. Ebmeier, J. Davidson, N. T. S. Evans, D. Roeda, R. Newton and J. R. Mallard, “Cerebral Blood-Flow Measured by Spect as a Diagnostic-Tool in the Study of Dementia,” Psychiatry Research, Vol. 29, 1989, pp. 327-329. doi:10.1016/0165-1781(89)90079-6
[30] R. Hargrave, R. J. Maddock and V. Stone, “Impaired Recognition of Facial Expressions of Emotion in Alzheimer’s Disease,” Journal of Neuropsychiatry Clinical Neurosciences, Vol. 14, 2002, pp. 64-71. doi:10.1176/appi.neuropsych.14.1.64
[31] J. Allender and A. W. Kaszniak. “Processing of Emotional Cues in Patients with Dementia of the Alzheimers Type.” International Journal of Neurosciences, Vol. 46, 1989, pp. 147-155. doi:10.3109/00207458908986252
[32] . A. Heinzel, F. Bermpohl, R. Niese, A. Pfennig, A. Pascual-Leone, G. Schlaug and G. Northoff, “How Do We Modulate Our Emotions? Parametric FMRI Reveals Cortical Midline Structures As Regions Specifically Involved in the Processing of Emotional Valences,” Cognitive Brain Research, Vol. 25, 2005, pp. 348-358.
[33] J. D. Teasdale, R. J. Howard, S. G. Cox, Y. Ha, M. J. Brammer, S. C. R. Williams and S. A. Checkley, “Functional MRI Study of the Cognitive Generation of Affect.” American Journal of Psychiatry, Vol. 156, 1999, pp. 209-215.
[34] J. Levesque, Y. Joanette, B. Mensour, G. Beaudoin, J. M. Leroux, P. Bourgouin and M. Beauregard, “Neural Basis of Emotional Self-Regulation in Childhood,” Neuroscience, Vol. 129, 2004, pp. 361-369. doi:10.1016/j.neuroscience.2004.07.032
[35] E. B. Mukaetova-Ladinska, F. Garcia-Siera, J. Hurt, H. J. Gertz, J. H. Xuereb, R. Hills, C. Brayne, F. A. Huppert, E. S. Paykel, M. McGee, R. Jakes, W. G. Honer, C. R. Harrington and C. M. Wischik, “Staging of cytoskeletal and beta-amyloid changes in human isocortex reveals biphasic synaptic protein response during progression of Alzheimer's disease,” American Journal of Pathology, Vol. 157, 2000, pp. 623-636. doi:10.1016/S0002-9440(10)64573-7
[36] H. Braak and E. Braak, “Neuropathological Staging of Alzheimer-Related Changes,” Acta Neuropathol ,Vol. 82, 1991, pp. 239-259. doi:10.1007/BF00308809
[37] J. C. Baron, G. Chetelat, B. Desgranges, G. Perch-ey, B. Landeau, V. de la Sayette and F. Eustache, “In Vivo Mapping of Gray Matter Loss with Voxel-Based Morphometry in Mild Alzheimer's Disease.” Neuroimage, Vol. 14, 2001, pp. 298-309. doi:10.1006/nimg.2001.0848
[38] R. I. Scahill, J. M. Schott, J. M. Stevens, M. N. Rossor and N. C. Fox, “Mapping the evolution of regional atrophy in Alzheimer's disease: Unbiased Analysis of Fluid-Registered Serial MRI,” Proceedings of National Academic Sciences in USA, Vol. 99, 2002, pp. 4703-4707. doi:10.1073/pnas.052587399
[39] J. V. Haxby, C. L. Grady, E. Koss, B. Horwitz, M. Schapiro, R. P. Friedland and S. I. Rapoport, “Heterogeneous Anterior-Posterior Metabolic Patterns in Dementia of the Alzheimer Type,” Neurology, Vol. 38, 1998,. pp. 1853-1863.
[40] J. D. Mayer, D. R. Caruso and P. Salovey, “Emotional Intelligence Meets Traditional Standards for an Intelligence,” Intelligence, Vol. 27, 1999, pp. 267-298. doi:10.1016/S0160-2896(99)00016-1
[41] R. T. Staff, A. D. Murray, I. J. Deary and L. J. Whalley, “What Provides Cerebral Reserve?” Brain, Vol. 127, 2004, pp. 1191-1199. doi:10.1093/brain/awh144
[42] A. D. Murray, R. T. Staff, S. D. Shenkin, I. J. Deary, O. M. Starr and L. J. Whalley, “Brain white Matter Hyperintensities: Relative Importance of Vascular Risk Factors in Nondemented Elderly People,” Radiology, Vol. 237, 2005, pp. 251-257. doi:10.1148/radiol.2371041496
[43] J. D. Henry, T. Ruffman, S. McDonald, M. P. O'Leary, L. H. Phillips, H. Brodaty and P. G. Rendell, “Recognition of disgust is Selectively Preserved in Alzheimer's Disease,” Neuropsychologia, Vol. 46, 2008, pp. 1363-1370. doi:10.1016/j.neuropsychologia.2007.12.012

  
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