Melanin Biosynthesis Inhibitory Activity of Compounds Isolated from Unused Parts of Ammi visinaga

DOI: 10.4236/jcdsa.2013.33A2010   PDF   HTML     3,471 Downloads   5,312 Views   Citations

Abstract

Ten compounds have been isolated from the unused parts of Ammi visinaga. The isolated compounds were identified as tetracosanoic acid (1), β-sitosterol (2), visnadine (3), khellin (4), β-sitosterol glucoside (5), norkhellol (6), khellol (7), rhamnazin (8), cimifugin (9), and cis-khellactone-3-β-glucopyranoside (10). The chemical structures of these compounds were elucidated based on spectroscopic data (NMR, UV, MS and IR spectra). This is the first report on the identification of tetracosanoic acid (1), norkhellol (6) and cimifugin (9) in the Ammi genus. The melanin biosynthesis inhibitory activities of khellin (4), khellol (7), visnadine (3), cimifugin (9), β-sitosterol (2) and β-sitosterol glucoside (5) were evaluated. Khellin (4) exhibited a potent melanin inhibitory effect compared to arbutin with less toxicity.

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A. Ashour, S. El-Sharkawy, M. Amer, F. Bar, R. Kondo and K. Shimizu, "Melanin Biosynthesis Inhibitory Activity of Compounds Isolated from Unused Parts of Ammi visinaga," Journal of Cosmetics, Dermatological Sciences and Applications, Vol. 3 No. 3B, 2013, pp. 40-43. doi: 10.4236/jcdsa.2013.33A2010.

Conflicts of Interest

The authors declare no conflicts of interest.

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