Share This Article:

Comparison of Malignant Bone Treatments for Reuse

Full-Text HTML XML Download Download as PDF (Size:1512KB) PP. 49-52
DOI: 10.4236/ss.2013.41009    3,770 Downloads   4,857 Views  

ABSTRACT

The After cancer resection including bone, recently, bone resected with cancer has been considered to be reusable. We newly examined superheated steam treatment for bone reuse and compared it to existing treatments. Forty male C3H/HeN mice were used to establish a model of mandible invasion by oral squamous cell carcinoma (OSCC). The mice were sacrificed to harvest the tumor invading mandible bone. The resected tumor with mandible bone was treated by one of four kinds of treatment, no treatment for the control, the Pasteur method, liquid nitrogen treatment, micro-wave treatment and superheated steam treatment. After each treatment, the resected bone was transplanted into a syn-geneic mouse back. Eight weeks after transplantation, the mice were sacrificed and evaluated pathologically. Grafted tumors showed recurrence: 7/7 in the control, 6/8 in the liquid nitrogen treatment, 1/8 the microwave treatment and 2/8 the superheated steam treatment groups. No recurrence, on the other hand, was observed in the Pasteur method (0/8). The Pasteur method is a good treatment to remove malignant cells.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Yazawa, M. , Mori, T. and Kishi, K. (2013) Comparison of Malignant Bone Treatments for Reuse. Surgical Science, 4, 49-52. doi: 10.4236/ss.2013.41009.

References

[1] N. Cui, T. Nomura, H. Noma, K. Yokoo, R. Takagi, S. Hashimoto, M. Okamoto, M. Sato, G. Yu, C. Guo and T. Shibahala, “Effect of YM529 on a Model of Mandibular Invasion by Oral Squamous Cell Carcinoma in Mice,” Clinical Cancer Research, Vol. 11, No. 7, 2005, pp. 2713-2719. doi:10.1158/1078-0432.CCR-04-1767
[2] Y. Takayama, T. Mori, T. Nomura, T. Shibahara and M. Sakamoto, “Parathyroid-Related Protein Plays a Critical Role in Bone Invasion by Oral Squamous Cell Carcinoma,” International Journal of Oncology, Vol. 36, No. 6, 2010, pp. 1387-1394.
[3] J. Manabe, A. R. Ahmed, N. Kawaguchi, S. Matsumoto and H. Kuroda, “Pasteurized Autologous Bone Graft in Surgery for Bone and Soft Tissue Sarcoma,” Clinical Orthopaedics and Related Research, Vol. 419, 2004, pp. 258-266. doi:10.1097/00003086-200402000-00042
[4] K. Sakayama, T. Kidani, T. Fujibuchi, J. Kamogawa, H. Yamamoto and T. Shibata, “Reconstruction Surgery for Patients Musculoskeletal Tumor, Using a Pasteurized Autogenous Bone Graft,” International Journal of Clinical Oncology, Vol. 9, No. 3, 2004, pp. 167-173. doi:10.1007/s10147-004-0391-7
[5] H. Nishida, H. Tsuchiya and K. Tomita, “Re-Implantation of Tumor Tissue Treated by Cryotreatment with Liquid Nitrogen Induces Anti-Tumor Activity against Murine Osteosarcoma,” Journal of Bone & Joint Surgery, Vol. 90-B, No. 9, 2008, pp. 1249-1255. doi:10.1302/0301-620X.90B9.20671
[6] H. Nishida, N. Yamamoto, Y. Tanzawa and H. Tsuchiya, “Cryoimmunology for Malignant Bone and Soft-Tissue Tumors,” International Journal of Clinical Oncology, Vol. 16, No. 2, 2011, pp. 109-117. doi:10.1007/s10147-011-0218-2
[7] Y. Tanzawa, H. Tsuchiya, T. Shirai, K. Hayashi, Z. Yo and K. Tomita, “Histological Examination of Frozen Autograft Treated by Liquid Nitrogen Removed after Implantation,” Journal of Orthopaedic Science, Vol. 14, No. 6, 2009, pp. 761-768. doi:10.1007/s00776-009-1392-1
[8] H. Tsuchiya, S. L. Wan, K. Sakayama, N. Yamamoto, H. Nishida and K. Tomita, “Reconstruction Using an Autograft Containing Tumor Treated by Liquid Nitrogen,” Journal of Bone & Joint Surgery, Vol. 87, No. 2, 2005, pp. 218-225. doi:10.1302/0301-620X.87B2.15325
[9] H. Tsuchiya, H. Nishida, P. Srisawat, T. Shirai, K. Hayashi, A. Takeuchi, N. Yamamoto and K. Tomita, “Pedicled Frozen Autograft Reconstruction in Malignant Bone Tumors,” Journal of Orthopaedic Science, Vol. 15, No. 3, 2010, pp. 340-349. doi:10.1007/s00776-010-1458-0
[10] N. Yamamoto, H. Tsuchiya and K. Tomita, “Effect of Liquid Nitrogen Treatment on the Proliferation of Osteosarcoma and the Biomechanical Properties of Normal Bone,” Journal of Orthopaedic Science, Vol. 8, No. 3, 2003, pp. 374-380. doi:10.1007/s10776-002-0626-3
[11] R. A. Dunsmuir and G. Gallacher, “Microwave Sterilization of Femoral Head Allograft,” Journal of Clinical Microbiology, Vol. 41, No. 10, 2003, pp. 4755-4757. doi:10.1128/JCM.41.10.4755-4757.2003
[12] Q. Y. Fan, B. A. Ma, X. C. Qiu, Y. L. Li, J. Ye and Y. Zhou, “Preliminary Report on Treatment of Bone Tumors with Microwave-Induced Hyperthermia,” Bioelectromagnetics, Vol. 17, No. 3, 1997, pp. 218-222. doi:10.1002/(SICI)1521-186X(1996)17:3<218::AID-BEM7>3.0.CO;2-6
[13] M. Liebergall, C. H. Abu-Sneineh, S. Eylon, S. Mendel-son, D. Segal and A. Simkin, “Effect of Microwave Oven Induced Mild Hyperthermia on Bone Viability and Strength,” Clinical Orthopaedics and Related Research, Vol. 372, 2000, pp. 272-279. doi:10.1097/00003086-200003000-00030
[14] S. S. Patel, A. A. Owida and Y. S. Morsi, “Microwave Sterilization of Bovine Pericardium for Heart Valve Applications,” Journal of Artificial Organs, Vol. 13, No. 1, 2013, pp. 24-30. doi:10.1007/s10047-010-0489-9
[15] K. Uchiyama, M. Ujihara, K. Mabuchi, N. Takahira, K. Komiya and M. Itoman, “Development of Heating Method by Microwave for Sterilization of Bone Allograft,” Journal of Orthopaedic Science, Vol. 10, No. 1, 2005, pp. 77-83. doi:10.1007/s00776-004-0857-5

  
comments powered by Disqus

Copyright © 2018 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.