With the aim of studying the anti-rutting performance of Thiopave modified asphalt mixture applied to the upper layer of pavement, the strain-hardening creep model in ABAQUS finite element software was used to analyze the rutting under the condition of introducing temperature field. Compared with the calculation results of the rutting of ordinary asphalt pavement, it is found that Thiopave can improve the temperature sensitivity of asphalt mixture. With the increase of temperature, the rutting change of Thiopave modified asphalt pavement is smaller than that of ordinary asphalt. Thiopave also has a certain degree of improvement in the fatigue resistance of asphalt pavements, which can be applied to sections with high traffic volume in high temperature areas.