Role of Dehydroepiandrosterone Supplementation in Improving Intracytoplasmic Sperm Injection Outcome for Women with Expected Poor Ovarian Response ()
ABSTRACT
Background: As regard to adjuvant supplementations, nowadays dehydroepiandrosterone
(DHEA) is widely used all over the world and is considered to be a potential
agent to ameliorate the assisted reproduction technologies outcomes of
infertile women with poor ovarian reserve. Objective: To find out the
role of DHEA supplementation in improving intracytoplasmic sperm injection
(ICSI) outcome for infertile women with expected poor ovarian response in
controlled ovarian stimulation. Setting: Assisted reproduction unit of
Obstetrics and Gynecology Department, Faculty of Medicine, South Valley University,
Egypt. Duration: From April 2016 to May 2018. Study Design: A
randomized double-blinded controlled trial. Methods: One hundred and
forty infertile women with expected poor ovarian response prepared for ICSI
procedure were included in this study. Patients were divided into two groups;
group I (DHEA group) included 70 patients received 25 mg DHEA 12 weeks prior to
ICSI cycle and group II (placebo group) included 70 patients received a
placebo. Results: There was a highly statistically significant difference
in basal AFC at start of ICSI cycle in group I (who received DHEA supplementation
for 12 weeks prior to ICSI procedure) than in group II (13.8 ± 5.3 versus 10.7 ±
4.6 respectively) with P < 0.001. There were mildly statistically significant
differences between group I and group II as regard to increase in the number
and quality of retrieved oocytes, increased in endometrial thickness,
fertilization rate and embryo quality with p value < 0.05 but there was no
statistically significant difference between the 2 groups as regard to
pregnancy (chemical and clinical) rates (p value > 0.05). Conclusions
& Recommendations: DHEA supplementations improved basal AFC, increased
the number & quality of oocytes and increased quality of embryos in
infertile patients with expected poor ovarian response in ICSI procedure. So
DHEA supplementations could be an important adjuvant for infertile women with
expected poor ovarian response in ICSI procedure.
Share and Cite:
Ali, A. and Khodry, M. (2019) Role of Dehydroepiandrosterone Supplementation in Improving Intracytoplasmic Sperm Injection Outcome for Women with Expected Poor Ovarian Response.
Open Journal of Obstetrics and Gynecology,
9, 353-362. doi:
10.4236/ojog.2019.93036.
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