Author(s)

Yicheng Liu¹, Xiazhang Li², Jen Sloppy³, Yan Huang^1*, Pingping Yao¹, Junya Yang¹, Yuxiang Yang^1*

¹School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, China.
²School of petrochemical engineering, Changzhou University, Changzhou, China.
³Department of Materials Science and Engineering, University of Delaware, Newark, DE, USA.

The magnetic hollow silica spheres (MHSS) with uniform cavity size and shell thickness were prepared by a simple and “green” method using functionalized SiO₂ spheres as templates. Magnetic particles (Fe₃O₄) were deposited on the SiO₂ surface by varying the molar ratio of [Fe²⁺]/[Fe³⁺] and the molar concentration of iron salts. The obtained magnetic hollow silica spheres exhibited a super-paramagnetic behavior at room temperature. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray powder scattering (XRD) were applied to characterize the MHSS. Besides, their unit cell parameters are calculated according to results indexing to XRD, the MHSS sample prepared at 0.10 M iron salts and 2:1 molar ratio of [Fe²⁺]/[Fe³⁺] has a largest cell angle (β) of unit cell. Due to large hollow cavity space and super-paramagnetic characteristics, the inner amino-functionalized MHSS could be labeled with radioisotope ⁹⁹Tc^m to study the MHSS’s magnetic targeting distribution in vivo. These results indicate that the MHSS has potential in the magnetic targeted drug delivery system which reduces the damage to normal cells and improves the therapeutic effect of cancer.

A Simple and “Green” Method, Magnetic Hollow Silica Spheres, Magnetic Targeting, Iron Salts, Radioisotope ⁹⁹Tc^m

Liu, Y. , Li, X. , Sloppy, J. , Huang, Y. , Yao, P. , Yang, J. and Yang, Y. (2017) A Simple and “Green” Method for Synthesis of Magnetic Hollow Silica Spheres and Its ⁹⁹Tc^m Labeled Targeting Studies. Open Journal of Inorganic Chemistry, 7, 1-15. doi: 10.4236/ojic.2017.71001.