Myeloperoxidase and High-Sensitivity C-Reactive Protein for Predicting Major Adverse Cardiovascular Events in Patients with Coronary Heart Disease - International Journal of Clinical Medicine

IJCM > Vol.6 No.4, April 2015

International Journal of Clinical Medicine

Volume 6, Issue 4 (April 2015)

ISSN Print: 2158-284X ISSN Online: 2158-2882

Google-based Impact Factor: 0.52 Citations h5-index & Ranking

Myeloperoxidase and High-Sensitivity C-Reactive Protein for Predicting Major Adverse Cardiovascular Events in Patients with Coronary Heart Disease ()

HTML XML

Download as PDF (Size: 411KB) PP. 262-270

DOI: 10.4236/ijcm.2015.64033 3,836 Downloads 5,489 Views Citations

Author(s)

Chenggui Liu^1*, Linong Chen¹, Yinzhong Yang², Cheng Huang¹, Jun Luo², Duanliang Peng²

Affiliation(s)

¹Department of Clinical Laboratory, Chengdu Women’s and Children’s Central Hospital, Chongqing Medical University, Chengdu, China.
²Department of Clinical Laboratory, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu, China.

ABSTRACT

Background: Research has shown that high-sensitivity C-reactive protein (hs-CRP) is a major inflammatory marker for prediction of acute coronary syndrome (ACS). Myeloperoxidase (MPO) also plays an important role in atherosclerosis initiation and development. In present study, the major adverse cardiovascular events (MACEs) of patients with coronary heart disease (CHD) were investigated. Methods: MPO, hs-CRP and ACS-related risk factors from 201 ACS (78 AMI and 123 UAP) and 210 non-ACS (84 SAP and 126 non-CHD) patients confirmed by coronary angiography were detected, and the data were analyzed with receiver operating characteristic (ROC) curve and Spearman’s correlation coefficients. MACEs of 285 CHD patients were investigated during the 4-year period follow-up from March 2010 to May 2014. Results: The areas under ROC curve for diagnosing ACS were 0.888 (95% CI 0.843 - 0.933) for MPO, and 0.862 (95% CI 0.815-0.910) for hs-CRP, respectively. There were significantly correlations between MPO and hs-CRP in both ACS and non-ACS groups. Regarding to ACS patients, both MPO and hs-CRP were positively correlated with BMI, TC, TG, LDL-C and Hcy. Prospective study demonstrated that the incidences of MACEs associated significantly with elevated MPO baseline level (yes vs no, OR 7.383, 95% CI 4.095 - 13.309) and high hs-CRP baseline level (yes vs no, OR 4.186, 95% CI 2.469 - 7.097) in CHD patients. Conclusions: The present study provides the epidemiological evidence that elevated baseline MPO and hs-CRP levels are both valuable predictors of MACEs in CHD patients. MPO and hs-CRP would prompt the progression of atherosclerosis and development from SAP to ACS.

KEYWORDS

Myeloperoxidase, High Sensitivity C-Reactive Protein, Acute Coronary Syndrome, Coronary Heart Disease, Major Adverse Cardiovascular Events

Share and Cite:

Liu, C. , Chen, L. , Yang, Y. , Huang, C. , Luo, J. and Peng, D. (2015) Myeloperoxidase and High-Sensitivity C-Reactive Protein for Predicting Major Adverse Cardiovascular Events in Patients with Coronary Heart Disease. International Journal of Clinical Medicine, 6, 262-270. doi: 10.4236/ijcm.2015.64033.

Cited by

[1]	Association of myeloperoxidase, homocysteine and high‑sensitivity C‑reactive protein with the severity of coronary artery disease and their diagnostic and prognostic …
	2020

[2]	Prognostic value of myeloperoxidase in patients with peripheral artery disease
	2020

[3]	Novos marcadores de doença coronária aguda: Síndrome coronário agudo
	2019

[4]	髓过氧化物酶与动脉粥样硬化及冠心病关系的研究进展
	山东医药, 2017

[5]	The roles of myeloperoxidase in coronary artery disease and its potential implication in plaque rupture
	Journal of Child Sexual Abuse, 2016

[6]	老年冠心病患者外周血同型半胱氨酸及尿酸水平与冠脉病变程度的相关性
	2016

Journals Menu

Follow SCIRP

	+1 323-425-8868
	customer@scirp.org
	+86 18163351462(WhatsApp)
	1655362766

	Paper Publishing WeChat

Journals Menu

Home

About SCIRP

Service

Policies