Dr. William F.
Carson
Department of Pathology,
University of
Michigan Medical School, USA
Email: wfcarson@umich.edu
Qualifications
2007 Ph.D., Biomedical Science–Immunology, University of Connecticut Health Center, USA
2002 B.S., Molecular and Cell
Biology, University of
Connecticut, USA
Publications(Selected)
Books
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Carson IV, W.F., Kunkel, S.L. “Molecular mechanisms underlying severe
sepsis: insights from epigenetics,” Annual Update in Intensive Care
and Emergency Medicine
2012 (2012) ISBN
978-3-642-25715-5, Springer, Berlin, Germany.
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Carson IV., W. F., Kunkel, S. L. “Immune cell dysfunction as a consequence
of severe sepsis,” Severe Sepsis and Septic Shock, 1st Ed. (2011) ISBN 978-953-307-854-0,
InTech, Rijeka, Croatia.
Journals
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Matakas, J.D., Balan, V., Carson IV, W.F., Gao, D., Brandizzi, F., Kunkel,
S.L., Sticklen, M. (2013) Plant-produced recombinant human interleukin-2 and
its activity against splenic CD4+ T cells. International Journal of Life
Sciences Biotechnology and Pharma Research, 2(2): 192-203.
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Mukherjee, S., Allen, R.M., Lukacs, N. W., Kunkel, S. L., Carson IV., W. F.
(2012) STAT3 mediated IL‐17 production by post‐septic T cells exacerbates viral
immunopathology of the lung. Shock Nov; 38(5)515-523.
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Ito, T., Allen, R. M., Carson IV., W. F., Schaller, M. A., Cavassani, K.
A., Hogaboam, C. M., Lukacs, N. W., Matsukawa, A., Kunkel, S. L. (2011) The
Critical Role of Notch Ligand Delta-like 1 in the Pathogenesis of Influenza A
Virus (H1N1) Infection. PLoS Pathogens Nov; 7(11): e1002341.
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Carson IV, W. F., Ito, T., Schaller, M., Cavassani, K. A., Chensue, S. W.,
Kunkel, S. L. (2011) Dysregulated cytokine expression by CD4+ T cells from
post-septic mice modulates both Th1 and Th2-mediated granulomatous lung inflammation
in adoptive transfer models. PLoS ONE 6(5): e20385.
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Ito, T., Carson IV, W. F., Cavassani, K. A., Connett, J. M., Kunkel, S. L.
(2011) CCR6 as a mediator of immunity in the lung and gut. Experimental Cell
Research Mar 10; 317(5): 613-619.
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Carson IV, W. F., Cavassani, K. A., Dou, Y. Kunkel, S. L. (2011) Epigenetic
regulation of immune cell functions during post-septic immunosuppression.
Epigenetics 6(3): 8-18.
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Schaller, M. A., Logue, H., Mukherjee, S., Lindell, D. M., Coelho, A. L., Lincoln,
P., Carson IV, W. F., Ito, T., Cavassani, K. A., Chensue, S. W., Hogaboam, C.
M., Lukacs, N. W., Kunkel, S. L. (2010) Delta-like 4 differentially regulates
murine CD4 T cell expansion via BMI1. PLoS One 5(8): e12172.
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Cavassani, K. A., Carson IV, W. F., Moreira, A. P., Wen, H., Schaller, M. A.,
Ishii, M., Lindell, D. M., Dou, Y., Lukacs, N. W., Keshamouni, V.G., Hogaboam,
C. M., Kunkel, S. L. (2010) The post sepsis-induced expansion and enhanced
function of regulatory T cells creates an environment to potentiate tumor growth.
Blood 2010 3; 115(22): 4403-4411.
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Carson IV, W. F., Cavassani, K. A., Ito, T., Schaller, M. A., Ishii, M., Kunkel,
S. L. (2010) Impaired CD4+ T cell proliferation and effector function correlates with repressive histone methylation events in a mouse model
of severe sepsis. Euro. J. Immunol. 40(4): 998-1010.
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Ishii, M., Wen, H., Corsa, C. A. S., Liu, T., Coehlo, A. L., Allen, R. M.,
Carson IV, W. F., Cavassani, K. A., Li, X., Lukacs, N. W., Hogaboam, C. M.,
Dou, Y., Kunkel, S. L. (2009) Epigenetic regulation of the alternatively
activated macrophage phenotype. Blood 114(15): 3244-3254.
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Ito, T., Schaller, M., Raymond, T., Joshi, A.D., Coelho, A.L., Frantz
F.G., Carson IV, W.F., Hogaboam, C.M., Lukacs, N.W., Standiford, T. J., Phan, S.H.,
Chensue, S. W., Kunkel, S. L. (2009) Toll-like Receptor 9 Activation is a Key
Mechanism for the Maintenance of Chronic Lung Inflammation. Am. J. Respir.
Crit. Care Med. 2009 Dec 15; 180(12): 1227-38.
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Singh, A., Carson IV, W. F., Secor Jr., E. R., Guernsey, L. A., Flavell,
R. A., Clark, R. B., Thrall, R. S., Schramm, C. M. (2008) Regulatory role of B
cells in a murine model of allergic airway disease. J. Immunol. 180(11): 7318-7326.
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Singh, A., Thrall, R.S., Guernsey, L.A., Carson IV, W. F., Secor Jr., E.
R, Cone, R. E., Rajan, T.V., Schramm, C. M. (2008) Subcutaneous late phase
responses are augmented during local inhalational tolerance in a murine asthma
model. Immunol. Cell Bio. 86(6): 535-538.
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Carson IV, W. F., Guernsey, L. A., Singh, A., Vella, A. T., Schramm, C. M., Thrall, R. S. (2007) Accumulation of regulatory T cells in local draining
lymph nodes of the lung correlates with spontaneous resolution of chronic
asthma in a murine model. Int. Arch. Allergy Immunol. 145(3): 231-243.
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Secor Jr., E. R., Carson IV, W. F., Singh, A., Pensa, M., Guernsey, L. A.,
Schramm, C. M., and Thrall, R. S. (2007) Oral bromelain attenuates inflammation
in an ovalbumin-induced murine model of asthma. Evid. Based Complement. Altern.
Med. Online Advanced Access (3-14-2007).
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Kabbur, P. M., Carson IV., W. F., Guernsey L. A., Secor Jr., E. R.,
Thrall, E. R., Schramm, C. M. (2006) Interleukin-10 does not mediate inhalational
tolerance in a chronic model of ovalbumin-induced allergic airway disease. Cell
Immunol. 239(1): 67-74.
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Secor Jr., E. R., Carson IV., W. F., Cloutier, M. M., Guernsey, L. A., Schramm,
C. M., Wu, C. A., Thrall, R. S. (2005) Bromelain exerts anti-inflammatory effects
in an ovalbumin-induced murine model of allergic airway disease. Cell Immunol.
237(1): 68-75.