Department of Molecular and Cellular Biochemistry

College of Medicine, University of Kentucky, USA

Scientist II

Email: mchow1@uky.edu

Qualifications

1998 Ph.D., University of California, Biology with Franz Engelmann

Publications (Selected)

1. Guan H, Chow K.M., Shah R., Rhodes C. J. and Hersh L. B. (2012). Degradation of islet amyloid polypeptide by neprilysin. Diabetologia. 55 (11): 2989-98.
2. Kessler J.H., Khan S., Seifert U., Le Gall S., Chow K. M., Paschen A., Bres-Vloemans S.A., de Ru A., van Montfoort N., Franken K.L., Benckhuijsen W.E., Brooks J.M., van Hall T., Ray K., Mulder A., Doxiadis I.I., van Swieten P.F., Overkleeft H.S., Prat A., Tomkinson B., Neefjes J., Kloetzel P.M., Rodgers D.W., Hersh L.B., Drijfhout J.W., van Veelen P.A., Ossendorp F., Melief C.J. (2011) Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes. Nat Immunol. 12 (1): 45-53.
3. Chow, K. M*, Guan, H. and L. B. Hersh. (2010) Aminopeptidases do not directly degrade tau protein. Mol Neurodegener. 5:48. *(Corresponding author)
4. Chow, K. M., Gakh, O., Payne, I. C., Juliano, M. A., Juliano, L., Isaya, G. & L. B. Hersh. (2009) Mammalian pitrilysin: substrate specificity and mitochondrial targeting. Biochemistry 48: 2868-2877.
5. Liu Y, Guan H, Beckett T.L., Juliano M.A., Juliano L., Song E.S., Chow K.M., Murphy M.P., Hersh L.B. (2007) In vitro and in vivo degradation of Abeta peptide by peptidases coupled to erythrocytes. Peptides. 28 (12): 2348-55.
6. Stricker, R., Chow, K. M., Walther, D., Hanck, T, Hersh, L. B. & Reiser, G. (2006). Interaction of the brain specific protein p42ip4 / centaurin-α1 with the peptidase nardilysin is regulated by the cognate ligands of p42ip4, ptdins (3,4,5) p3 and ins (1,3,4,5) p4, with stereospecificity. J. Neurochem. 98 (2): 343-54.
7. Chow, K. M.*, Ma Z, Cai, J., Pierce, W. M. & Hersh, L. B. (2005) Nardilysin facilitates complex formation between mitochondrial malate dehydrogenase and citrate synthase. Biochim Biophys Acta. 1723 (1-3): 292-301. *(Corresponding author)
8. Ma, Z., Chow K. M. Yao J., & Hersh L. B. (2004) Nuclear shuttling of the peptidase nardilysin. Arch Biochem Biophys 422 (2): 153-60.
9. Chow, K. M., Oakley, O., Goodman, J. Ma, Z., Juliano, M. A., Juliano, L. & Hersh, L. B. (2003) Nardilysin cleaves peptides at monobasic sites. Biochemistry 42 (7): 2239-44
10. Miller B.C., Eckman E.A., Sambamurti K, Dobbs N., Chow K. M. , Eckman C. B., Hersh L. B., Thiele DL. (2003) Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo. Proc Natl Acad Sci U S A. 100 (10): 6221-6.
11. Ma, Z., Chow, K. M., Csuhai, E, and Hersh, L. B. (2002). The use of proteolysis to study the structure of nardilysin. Archives of Biochemistry and Biophysics 401 (2): 198-204.
12. Ma, Z., Csuhai, E., Chow, K. M., & Hersh, L. B. (2001) Expression of the acidic stretch of nardilysin as a functional binding domain. Biochemistry 40: 9447-9452.
13. Chow, K. M., Csuhai, E., Juliano, M. A., Pyrek, J. S., Juliano, L., and Hersh, L. B., (2000).
14. Studies on the Subsite Specificity of Rat Nardilysin (N-Arginine Dibasic Convertase). J. Biol. Chem., 275, 19545-19551.