Prof. Zhixiang Wang
Department of Cell Biology
Faculty of Medicine and Dentistry
University of Alberta, Canada
Email:zhixiang.wang@ualberta.ca
Qualifications
1989-1993 Ph.D., Biochemistry, Simon Fraser University, Canada
1982-1985 M.S., Zoology, Academia Sinica, China
1978-1982 B.S., Biology, Peking University, China
Publications(Selected)
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Chen C., Uludag H.,Wang Z., Rezansoff A., Jiang H. (2011)inhibit migration, metabolic activity and osteogenic differentiation of human mesenchymal stem cells in vitro.Cells Tissues Organs (in press)
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Liu, L., Shi, H., Chen, X. andWang, Z.(2011) Regulation of EGF Receptor Endocytosis during Mitosis.Traffic12: 201-217.
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Pahara, J., Shi, H., Chen, X. andWang, Z.(2010)Dimerization Drives PDGF Receptor Endocytosis through a C-terminal Hydrophobic Motif Shared by EGF Receptor.Exp. Cell Res 15: 2237-50.
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Li, S, Wang, Q, Wang,Y. Chen, X. andWang, Z.(2009) PLC-γ1 and Rac1 co-regulates EGF-induced cytoskeleton remodelling and cell migration.Molecular Endocrinology23: 901-913.
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Pennock, S. andWang, Z. (2008) A Tale of Two Cbls:Interplay of c-Cbl and Cbl-b in Epidermal Growth Factor Receptor Downregulation.Mol. Cell. Biol.28: 3020-3037.
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Wang, Q.,Wu, F., andWang, Z.(2007)Identification of EGF Receptor C-terminal Sequences 1005-1017 and Di-leucine Motif1010LL1011as Essential in EGF Receptor Endocytosis.Exp. Cell Res.313: 3349-3363.
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Wang, Y., Wu, J. andWang, Z.(2006) Akt binds to and phosphorylates phospholipase C-gamma1 in response to epidermal growth factor.Mol. Biol. Cell17: 2267-2277.
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Wang, Q., Villeneuve, G., andWang, Z.(2005) Control of epidermal growth factor receptor endocytosis by receptor dimerization, rather than receptor kinase activation.EMBO Rep.,6: 942-948.
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Wang, Y., Pennock, S., Chen, X.,Kazlauskas, A. andWang, Z.(2004) PDGF receptor-mediated signal transduction from endosomes.J. Biol. Chem.279: 8038-8046
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Wang, Y. andWang, Z.(2003) Regulation of EGF-induced phospholipaseC-1 translocation and activation by its SH2 and PH domains.Traffic4: 618-630
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Pennock, S. and Wang, Z. (2003)Stimulation of cell proliferation by endosomal epidermal growth factor receptor as revealed through two distinct phases of signaling.Mol. Cell. Biol.23: 5803-5815
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Wang Y, Pennock S, Chen X. andWang Z.. Internalization of inactive EGF receptor into endosomes and the subsequent activation of endosome-associated EGF receptors. Sci. STKE 2002(161): PL17 .
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Wang, Y., Pennock, S, Chen, X. andWang, Z.(2002) Endosomal signaling of epidermal growth factor receptor stimulates signal transduction pathways leading to cell survival.Mol. Cell. Biol.22 (20): 7279-7290 [Cover illustration onMCB22 (22)].Science's STKEhighlighted this paper in "This Week in Signal Transduction" for the October 1 issue.
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Wang, Z.and Moran, M. (2002)Phospholipase C-1: a Phospholipase and Guanine Nucleotide Exchange Factor.Molecular Intervention2: 352-355
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Chen, X. andWang, Z.(2001) Regulation of epidermal growth factor receptor endocytosis by wortmannin through activation of Rab5 rather than inhibition of phosphatidylinositol 3-kinase.EMBO Reports2: 842-849.
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Chen, X. andWang, Z.(2001)Regulation of EGF receptor intracellular trafficking by Rab5 in the absence of Phosphatidylinosito 3-kinase activity.EMBO Reports2:68-74. (with Cover Illustration)
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Dankort, D., Maslikowski, B., Warner, N., Kanno N. Kim, H.,Wang, Z.,Moran, M.F., Oshima, R.G., Cardiff, R. D. and Muller, W. (2001) Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: Implications for human breast cancer.Mol. Cell. Biol.21:1540-1551.
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Chen, X., Yeung, K. T. and Wang, Z. (2000)Enhanced drug resistance in cells coexpressing ErbB2 with EGFR or ErbB3.Biochem. Biophys. Res. Commun.277: 757-763.