Dr. Zhiwei Hu
The
OSU James Comprehensive Cancer Center, Department of Surgery, College of
Medicine
The
Ohio State University, USA
Associate
Professor
Email:
zhiwei.hu@osumc.edu
Qualifications
1997
Ph.D., Tumor Immunobiology, Hunan Medical University, China
1994
M.Sc., Tumor Immunology, Jiangxi Medical College, China
1991
M.D., Medicine and Stomatology, Jiangxi Medical College, China
Publications
(Selected)
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Zhiwei
Hu*, Samira A. Brooks, Valérian Dormoy, Chia-Wen Hsu, Hsue-Yin Hsu, Liang-Tzung
Lin, Thierry Massfelder, W. Kimryn Rathmell, Menghang Xia, Fahd Al-Mulla,
Rabeah Al-Temaimi, Amedeo Amedei, Dustin Brown, Kalan R Prudhomme, Annamaria
Colacci, Roslida A. Hamid, Chiara Mondello, Jayadev Raju, Elizabeth Ryan,
Jordan Woodrick, Ivana Scovassi, Neetu Singh, Monica Vaccari, Rabindra Roy, Stefano
Forte, Lorenzo Memeo, Hosni K. Salem, Leroy Lowe, Lasse Jensen, William H.
Bisson, Nicole Kleinstreuer. (2015) Assessing the Carcinogenic Potential of Low
Dose Exposures to Chemical Mixtures in the Environment: Focus on the Cancer
Hallmark of Tumor Angiogenesis. Carcinogenesis. 2015 Jun;36 Suppl 1:S184-202.
doi: 10.1093/carcin/bgv036.
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Zhiwei
Hu*, Nancy Oleinick and Michael R Hamblin. (2014) Photodynamic Therapy as an
Emerging Treatment Modality for Cancer and Non-Cancer Diseases. J Anal Bioanal
Tech. S1: e001. doi: 10.4172/2155-9872. S1-e001.
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Zhiwei
Hu. (2013) Overcome the impairment of NK cells for Icon and antibody
immunotherapy of cancer. Journal of Immune Based Therapy, Vaccines and
Antimicrobials. 2(1): 1-8.
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Zhiwei
Hu. (2012) Dual targeting of tumor neovasculature and tumor cells by tissue
factor-targeted photodynamic therapy. Journal of Analytical & Bioanalytical
Techniques. 3(4) e105.
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Jijun
Cheng, Jie Xu, Jinzhong Duanmu, Han Zhou, Carmen J. Booth and Zhiwei Hu.
(2011) Effective treatment of human lung cancer by targeting tissue factor with
a factor VII-targeted photodynamic therapy. Current Cancer Drug Targets. 11(9):
1069-1081.
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Jinzhong
Duanmu, Jijun Cheng, Jie Xu, Carmen J. Booth and Zhiwei Hu(2011). Effective
treatment of chemoresistant breast cancer in vitro and in vivo by a factor VII-targeted
photodynamic therapy. British Journal of Cancer. 104(9): 1401-1409.
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Zhiwei
Hu, Benqiang Rao, Shimin Chen and Jinzhong Duanmu. (2011) Selective and
effective killing of angiogenic vascular endothelial cells and cancer cells by
targeting tissue factor using a factor VII-targeted photodynamic therapy for
breast cancer. Breast Cancer Research and Treatment. 126(3): 589-600.
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Zhiwei
Hu and Jing Li (2010). Natural killer cells are crucial for the efficacy of
Icon (factor VII/human IgG1 Fc) immunotherapy in human tongue cancer. BMC
Immunology. 2010, 11(1):49. This article has been labeled as “Highly Accessed”
by the Journal and is publicly available at
http://www.ncbi.nlm.nih.gov/pubmed/20939894.
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Zhiwei
Hu, Benqiang Rao, Shimin Chen and Jinzhong Duanmu. (2010) Targeting tissue
factor on tumour cells and angiogenic vascular endothelial cells by factor
VII-targeted verteporfin photodynamic therapy for breast cancer in vitro and in
vivo in mice. BMC Cancer. 2010, 10:235. This article is publicly available at http://www.ncbi.nlm.nih.gov/pubmed/20504328.
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Emiliano
Cocco, Zhiwei Hu, Christine E. Richter, Stefania Bellone, Francesca Casagrande,
Marta Bellone, Paola Todeschini, Graciela Krikun, Dan-Arin Silasi, Masoud
Azodi, Peter E. Schwartz, Thomas J. Rutherford, Sergio Pecorelli, Charles J.
Lockwood, and Alessandro D. Santin. (2010) hI-con1, a factor VII-IgGFc chimeric
protein targeting tissue factor for immunotherapy of uterine serous papillary
carcinoma. British Journal of Cancer. 103(6): 812-9.
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Graciela
Krikun, Zhiwei Hu, Kevin Osteen, Kaylon Tran-Brunner, Frederick Schatz, Hugh S.
Taylor, Paolo Toti, Felice Arcuri, William Konigsberg, Alan Garen, Carmen J.
Booth, and Charles J. Lockwood. (2010) Targeting Tissue Factor with the
Immunoconjugate “Icon” Leads To the Regression of Endometriosis Through
Destruction of Aberrant Blood Vessels. American Journal of Pathology
176(2): 1050-1056.
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Fang
Lu, Zhiwei Hu, John Sinard, Alan Garen, and Ron A Adelman. (2009) Factor
VII–verteporfin for Targeted Photodynamic Therapy in a Rat Model of Choroidal
Neovascularization. Investigative Ophthalmology & Visual Science. 50(8):
3890-6.
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Joseph
S. Palumbo, Kathryn E. Talmage, Jessica V. Massari, Christine M. La Jeunesse,
Matthew J. Flick, Keith W. Kombrinck, Zhiwei Hu, Kelley A. Barney, and Jay L.
Degen. (2007) Tumor cell-expressed tissue factor and circulating coagulation
factors cooperatively increase metastatic potential through natural killer
cell-dependent and cell-independent mechanisms. Blood. 110(1): 133-41.
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Tongalp
H. Tezel, Ewa Bodek, Kenan Sönmez, Sankar Kaliappan, Henry J. Kaplan, Zhiwei
Hu, Alan Garen. (2007) Targeting tissue factor for immunotherapy of choroidal
neovascularization by intravitreal injection of factor VII-IgG1 Fc chimeric
antibody. Ocular Immunology and Inflammation. 15: 3-10.
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Yucheng
Tang, Per Borgstrom, Jonathan Maynard, Zhiwei Hu, Alan Garen, and Albert
Deisseroth. (2007) Mapping of angiogenic markers for targeting of vectors to
tumor vascular endothelial cells. Cancer Gene Therapy. 14: 346-353.
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Puran
S. Bora, Zhiwei Hu, Tongalp H. Tezel, Jeong- Hyeon Sohn, Shin Goo Kang, Jose M.
Cruz, Nalini S. Bora, Alan Garen and Henry J. Kaplan. (2003) Immunotherapy for
choroidal neovascularization in a laser-induced mouse model simulating
exudative (wet) macular degeneration. Proc. Natl. Acad. Sci. USA. 100:
2679-2684.
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Zhiwei
Hu. Antigen-driven stimulation of B-lymphocytes in vitro. In O’Brian, P.M and
Aitken, R., ed., Methods in Molecular Biology, Volume 178: Antibody Phage
Display: Methods and Protocols. The Humana Press Inc., New Jersey, USA. 2002; p
113-119.
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Zhiwei
Hu and Alan Garen. (2001) Targeting tissue factor on tumor vascular endothelial
cells and tumor cells for immunotherapy in mouse models of prostatic cancer.
Proc. Natl. Acad. Sci. USA. 98: 12180-12185.
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Zhiwei
Hu and Alan Garen. (2000) Intratumoral injection of adenoviral vectors encoding
tumor-targeted immunoconjugates for cancer immunotherapy. Proc. Natl. Acad.
Sci. USA. 97: 9221-9225.
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Zhiwei
Hu, Ying Sun and Alan Garen. (1999) Targeting tumor vasculature endothelial
cells and tumor cells for immunotherapy of human melanoma in a mouse xenograft
model. Proc. Natl. Acad. Sci. USA. 96: 8161-8166.