Dr. Raymond Chuen-Chung Chang

The University of Hong Kong (China)

Assistant Professor

Email: rccchang@hku.hk

Qualifications

1997 Ph.D., University of Munich, Human Biology

1993 MPhil, The Chinese University of Hong Kong, Biochemistry

1991 B.Sc., The Chinese University of Hong Kong, Biochemistry

Publications (selected)

1. Ho YS, Yang X, Yeung SC, Chiu K, Lau JCF, Tsang AWT, Mak JCW,Chang RCC* (2012) Cigarette smoking accelerated brain aging and induced pre-Alzheimer-Like neuropathology in rats.PloS One, 7(5), e36752
   (doi:10.1371/journal.pone.0036752).
   [Impact factor: 4.411; Rank of Journal: 12/86 (Top: 13.95%) in the field of Biology; 5% effort]
2. Ho YS, Yang X, Lau JCF, Hung CHL, Wuwongse S, Zhang Q, Wang JZ, Baum L, So KF andChang RCC* (2012) Endoplasmic reticulum stress induces tau pathology and forms a vicious cycle: Implication in Alzheimer’s disease pathogenesis.J. Alz. Dis., 128, 839-854. [Correspondence author; Impact factor: 4.261 in the field of neuroscience; Rank of Journal: 58/237 (Top 24.5%) in the field of Neuroscience; 30% effort].
3. Chiu K, Chan TF, Wu A, Leung IYP, So KF,Chang RCC* (2012) Neurodegeneration in the retina of mouse models of Alzheimer’s disease: what can we learn from the retina? AGE, 34, 633-649 (DOI: 10.1007/s11357-011-9260-2) [Correspondence author; Impact factor: 6.280; Rank of Journal: 4/44 (Top: 9.1%) in the field of Geriatric & Gerontology; Citation index: 1; 30% effort].
4. Ho YS, Poon DCH, Chan TF, Chang RCC* (2012) From small to big molecules: how do we prevent and delay progression of aging-related neurodegeneration? Curr. Pharmaceut. Design, 18, 15-26. [Correspondence author; Impact factor: 4.774; Rank of Journal: 22/249 (Top: 8.8%) in Pharmacology & Pharmacy; Citation index: 1; 30% effort].
5. Chao J, Leung Y, Wang M, Chang RCC* (2012) Nutraceuticals and their preventive or potential therapeutic value for Parkinson’s disease. Nutr. Rev., In press.[Correspondence author; Impact factor: 4.077; Rank of Journal: 9/70 (Top: 12.9%) in Nutrition & Dietetics; 30% effort].
6. Xiao J, Liong EC, Ching YP, Chang RCC, So KF, Fung ML, Tipoe GL (2012) Lycium barbarum polysaccharides protect mice liver from carbon tetrachloride-induced oxidative stress and necroinflammation. J. Ethnopharmacol., 139, 462-470. (doi: 10.1016/j.jep.2011.11.033). [Impact factor: 2.466; Rank of Journal: 4/21 (Top: 19.1%) in Integrative & Complementary Medicine; 10% effort].
7. Yang D, Li SY, Yeung CM, Chang RCC, So KF, Wong D, Lo ACY (2012) Lycium barbarum extracts protect the brain from blood-brain-barrier disruption and cerebral edema in experimental stroke. PloS One, 7, e33596. [Impact factor: 4.411; Rank of Journal: 12/85 (Top: 14.1%) in the field of Biology; 5% effort].
8. Mi XS, Chiu K, Van G, Leung JW, Lo AC, Chung SK, Chang RCC, So KF (2012) The effects of Lycium barbarum on the expression of endothelin-1 and its receptors in an ocular hypertension model of rat glaucoma. Neural Regeneration Res., 7, 645-651.
9. Lau BWM, Lee CD, Li Y, Fung SMY, Sang YH, Shen J, Chang RCC, So KF (2012) Polysaccharides from Wolfberry prevents corticosterone-induced inhibition of sexual behavior and increases neurogenesis. PloS One, 7, e33374. [Impact factor: 4.411; Rank of Journal: 12/85 (Top: 14.1%) in the field of Biology; 5% effort].
10. Klionsky DJ, Abdalla FC, Chang RCC, Che CM, Zuckerbraun B (2012) Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 8, 1-100. (more than 100 authors to launch the guideline for monitoring autophagy)[Impact factor: 6.643; Rank of Journal: 34/178 (Top: 19.1%) in the field of Cell Biology; 2% effort].
11. Cheung YT, Zhang NQ, Hung CHL, Lai CSW, Yu MS, So KF and Chang RCC* (2011) Temporal Relationships of autophagy and neuronal apoptosis in low molecular weight β-amyloid peptide neurotoxicity. J. Cell. Mol. Med., 15, 244-257. [Correspondence author; Impact factor: 4.608; Rank of Journal: 18/106 (Top: 17.0%) in the field of Medicine: Research and Experimental; Citation index: 1; 30% effort].
12. Ho YS, So KF and Chang RCC* (2011) Drug discovery from Chinese Medicine against neurodegeneration in Alzheimer’s and vascular dementia. CHINESE MEDICINE, 6:15. [New Journal with pending impact factor; Citation index: 2].
13. Lau BW, Ren C, Yang JL Yan SW, Chang RCC, Pu M, So KF (2011) Light deprivation induces depression-like behavior and suppresses neurogenesis in diurnal Mongolian gerbil (Meriones unguiculatus). Cell Transplant., 20, 871-881. [Impact factor: 6.204; Rank of Journal: 1/25 (Top: 4%) in the field of Transplantation; 5% effort].
14. Li SY, Yang D, Yeung CM, Yu WY, Chang RCC, So KF, Wong D, Lo ACY (2011) Lycium barbarum polysaccharides reduce neuronal damage, blood-retinal barrier disruption and oxidative stress in retinal ischemia/reperfusion injury. PloS One, e16380. [Impact factor: 4.411; Rank of Journal: 12/85 (Top: 14.1%) in the field of Biology; Citation index: 5; 5% effort].
15. Ho YS, Yu MS, Yang X, So KF, Yuen WH and Chang RCC* (2010) Neuroprotective effects of polysaccharides from Wolfberry antagonize homocysteine-induced toxicity in rat cortical neurons. J. Alzheimer Dis., 19, 813-827. (Correspondence author; Impact factor: 4.261 in the field of neuroscience; Rank of Journal: 58/237 (Top 24.5%) in the field of Neuroscience; Citation index: 15; 30% effort).
16. Ho YS, So KF and Chang RCC* (2010) Anti-aging herbal medicine – how and why can they be used in aging-associated neurodegenerative diseases? Ageing Res. Rev., 9, 354-362. (Correspondence author; Impact factor: 9.0; Rank of Journal: 1/44 (Top: 2.3%) in the field of Geriatric & Gerontology; citation index: 12; 30% effort).
17. Wuwongse S, Chang RCC* and Law ACK (2010) The putative neurodegenerative links between depression and Alzheimer’s disease. Prog. Neurobiol., 91, 362-375. (Correspondence author; Impact factor: 9.966; Rank of Journal: 10/237 (Top: 4.2%) in the field of Neuroscience; Citation index: 10; 30% effort).
18. Chao J, Li H, Cheng KW, Yu MS, Chang RCC* and Wang M (2010) Protective effects of pinostilbene, a resveratrol methylated derivative, against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells. J. Nutr. Biochem., 21, 482-489. (Correspondence author; Impact factor: 4.538; Rank of Journal: 5/70 (Top: 7.1%) in the field of Nutrition & Dietetics; Citation index: 4; 30% effort).
19. Yu JT, Chang RCC and Tan L (2009) Calcium dysfunction in Alzheimer’s disease: From basic mechanisms to therapeutic opportunities. Prog. Neurobiol., 89, 240-255. (Impact factor: 9.140; Rank of Journal: 12/230 (Top: 5.2%) in the field of Neuroscience; citation index: 25; 20% effort).
20. Ho YS, Yik SY, Yu MS, So KF, Yuen WH and Chang RCC* (2009) Anti-aging Lycium barbarum antagonizes glutamate excitotoxicity in rat cortical neurons. Cell. Mol. Neurobiol., 29, 1233-1244.(Correspondence author; Impact factor: 2.107; Rank of Journal: 157/231 (Top: 67.9%) in the field of Neuroscience; citation index: 13; 30% effort).
21. Chang RCC* and So KF (2008) Use of anti-aging herbal medicine, Lycium barbarum, against aging-associated diseases. What do we know so far? Cell. Mol. Neurobiol., 28, 643-652.(Correspondence author; Impact factor: 2.550; Rank of Journal: 117/219 (Top: 53.4%) in the field of Neuroscience; Citation index: 39; 80% effort).
22. Lai CSW, Yu MS, Yuen WH, So KF, Zee SY and Chang RCC* (2008) Neuroprotective effects of anti-aging fungus Gandoderma lucdium. Brain Res., 1190, 215-224. (Correspondence author; Impact factor: 2.494; Rank of Journal: 120/219 (Top: 54.8%) in the field of neuroscience; citation index: 14; 30% effort).
23. Chao J, Yu MS, Ho YS, Wang M and Chang RCC* (2008) Dietary oxyresveratrol prevents parkinsonian mimetic 6-hydroxydopamine neurotoxicity. Free Radic. Biol. Med., 45, 1019-1026.(Correspondence author; Impact factor: 6.081; Rank of Journal: 12/105 (Top: 11.4%) in the field of Endocrinology & Metabolism; Citation index: 35; 30% effort).

Profile Details

http://www.researcherid.com/rid/C-1107-2009