Prof. Kevin D. Brown
University of
Florida Shands Cancer Center, USA
Email:
kdbrown1@ufl.edu
Qualifications
1991 Ph.D., University of Alabama, Cell & Molecular Biology
1987 M.A., Francisco State University, Cell & Molecular Biology
1981 B.Sc., University of Massachusetts, Medical Technology
Publications
(selected)
-
Turner J, Koumenis C, Kute TE, Planalp RP, Brechbiel MW, Beardsley DI,
Cody B, Brown KD, Torti FM, Torti SV. 2005. Tachpyridine, a metal chelator, induces G2 cell cycle arrest,
activates checkpoint kinases, and sensitizes cells to ionizing radiation. Blood, 106: 3191-3199.
-
Ai, L, Tao, Q,
Zhong, S, Fields, CR, Kim, W-J, Lee, MW, Cui, Y, Brown, KD and Robertson,
KD. 2006. Inactivation of Wnt inhibitory factor-1 (WIF1) expression by
epigenetic silencing is a common event in breast cancer. Carcinogenesis, 27: 1341-48.
-
Ai, L, Kim,
W-J, Kim, T-Y, Fields, CR, Massoll, NA, Robertson, KD, Brown, KD. 2006.
Epigenetic silencing of the tumor suppressor cystatin M occurs during breast
cancer progression. Cancer Research, 66: 7899-7909.
-
Kim, WJ,
Rajasekaran, B, and Brown, KD. 2007. MLH1 and ATM-dependent MAP kinase signaling is activated through c-Abl in
response to the alkylator N-methyl-N’-nitro-N-nitrosoguanidine J. Biol. Chem., 282: 32021-32031.
-
Lee, MW, Kim,
WJ, Beardsley, DI and Brown, KD. 2007. N-methyl-N’-nitro-N-nitrosoguanidine
activates both caspase-dependent and independent cell death mechanisms in human
fibroblasts DNA and Cell. Biol., 26: 683-694.
-
Brown, KD and
Robertson, KD. 2007. DNMT1 knockout delivers a strong blow to genome stability and cell
viability. Nature Genetics, 39: 289-90.
-
Palii, S., Van
Emburgh, B.O., Sankpal, U.T, Brown, K.D. and Robertson, K.D. 2008. The DNA
methylation inhibitor 5-aza-2’-deoxycytidine (5-azadC) induces reversible
genome-wide DNA damage that is distinctly influenced by DNA methyltransferases
(DNMTs) 1 and 3B. Molec. Cell Biol., 28: 752-71.
-
Zheng, L., Asprodites, N., Keene, A.H., Rodriguez, P., K.D. Brown, and
Davila, E. 2008. TLR engagement on CD4 T lymphocytes -radiation–induced
repressesgapoptosis through activation of checkpoint kinase response elements. Blood, 111(5): 2704-13.
-
Ai, L., Kim,
W-J, Demircan, B., Dyer, L.M., Bray, K.J., Skehan, R.R, Massoll, N.A., Brown,
K.D. 2008. The transglutaminase 2 gene (TGM2), a potential molecular marker for
chemotherapeutic drug sensitivity, is epigenetically silenced in breast
cancer. Carcinogenesis, 29(3): 510-8.
-
Qiu, J., Ai,
L., Ramachandran, C., Yao,B., Gopalakrishnan, S., Fields, C.R., Delmas, A.L,.
Dyer, L.M., Melnick, S.J., Yachnis, A.T., Schwartz, P.H., Fine, H.A., Brown,
K.D. and Robertson, K.D. 2008. Invasion suppressor cystatin E/M (CST6):
High-level cell type-specific expression in normal brain and epigenetic
silencing in brain tumors. Lab Invest., 9: 910-25.
-
Demircan, B.,
Dyer, LM, Gerace, M, Lobenhofer, E.K., Robertson, KD and Brown, KD. 2009.
Comparative epigenomics of human and mouse mammary tumors. Genes, Chrom and
Cancer, 48: 83-97.
-
Orlando, FA,
and Brown, KD. 2009. Unraveling Breast Cancer Heterogeneity Through Transcriptomic and
Epigenomic Analysis. Ann. Surg. Oncol., 16(8): 2270-9.
-
Jiang Z, Jin S, Yalowich JC, Brown KD, Rajasekaran B. 2010. The Mismatch Repair System Modulates Curcumin Sensitivity through
Induction of DNA Strand Breaks and Activation of G2-M Checkpoint. Mol
Cancer Ther., 9: 558-68.
-
Dyer LM,
Schooler KP, Ai L, Klop C, Qiu J, Robertson KD, Brown KD. 2011. The
transglutaminase 2 gene is aberrantly hypermethylated in glioma. J Neurooncol., 101: 429-40.
-
Delmas, AL,
Riggs, BM, Pardo, CE, Dyer, LM, Darst, RP, Izumchenko, E, Monroe, M, Hakam, A,
Kladde, MP, Siegel, EM and Brown, KD. 2011. WIF1 is a Frequent Target for
Epigenetic Silencing in Squamous Cell Carcinoma of the Cervix. Carcinogenesis, 32: 1625-33.
-
Chen M,
Shabashvili D, Nawab A, Yang SX, Dyer LM, Brown KD, Hollingshead M, Hunter KW,
Kaye FJ, Hochwald SN, Marquez VE, Steeg P, Zajac-Kaye M. 2012. DNA
methyltransferase inhibitor, zebularine, delays tumor growth and induces
apoptosis in a genetically engineered mouse model of breast cancer. Mol Cancer
Ther., 11: 370-82.
-
Ai, L, Skehan,
RR, Saydi, J, Lin, T, and Brown, KD Ataxia-Telangiectasia, Mutated (ATM) /
Nuclear Factor Kappa light chain enhancer of activated B cells (NF kappaB)
Signaling Controls Basal and DNA Damage-Induced Transglutaminase 2 Expression.
J. Biol. Chem. (in press).