Prof. Chi-Hin Cho
The Chinese University of Hong Kong, China
Email: chcho@cuhk.edu.hk
Qualifications
1975-1978 Ph.D., Department of
Pharmacology, The University of Hong Kong, China
1973-1975 M. Sc., Department of
Pharmacology, University of Wisconsin, USA
1968-1972 B. Pharm., School of
Pharmacy, National Defense Medical Center, Taiwan
Publications (Selected)
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Chow, J.Y.C., Ma, L. & Cho, C.H.
(1997). The potentiating action of cigarette smoke on ethanol-induced
gastric mucosal damage in rats. Gastroenterology 113, 1188-1197.
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Guo, X., Wang, W.P., Ko, J.K.S. & Cho, C.H. (1999).
Involvement of neutrophils and free radicals in the potentiating effects of
passive cigarette smoking on experimental inflammatory bowel disease in rats.
Gastroenterology, 117: 884-892.
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Ma, L, Wang, W.P., Chow, J.Y.C., Lam, S.K. & Cho, C.H.
(2000). The role of polyamine in gastric mucus synthesis inhibited by cigarette
smoke or its extracts. Gut 47, 170-177.
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Wang, W.P., Guo, X., Koo, M.W.L., Wong, B.C.Y. Lam, S.K.,
Ye, Y.N. & Cho, C.H. (2001). Protective effect of heme oxygenase-1 on
trinitrobenzene sulfonic acid-induced colitis in rats. Am. J. Physiol.
Gastrointest. Liver Physiol. 281, G586-G594.
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Wong, B.C.Y. Wang, W.P., So, W.H.L., Shin, V.Y., Wong,
W.M., Fung, F.M., Liu, E.S.L., Hui, W.M., Lam, S.K. & Cho, C.H. (2001).
Epidermal growth factor and its receptor in chronic active gastritis and
gastroduodenal ulcer before and after Helicobacter
pylori eradication. Aliment.
Pharmacol. Therap. 15, 1459-1465.
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Liu, E.S.L., Ye, Y.N., Shin, V.Y., Yuen, S.T. Leung, S.Y.,
Wong, B.C.Y. & Cho, C.H. (2003). Cigarette smoke exposure increases
ulcerative colitis-associated colonic adenoma formation in mice. Carcinogenesis
24, 1407-1413.
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Ye, Y.N., Liu, E.S.L., Shin, V.Y., Wu, W.K.K. & Cho,
C.H. (2004). The modulating role of NF-kB in the action of a7 nAChR
and cross-talk between 5-LOX and COX-2 in colon cancer cell growth induced by
4-(N-methyl-N-nitrosamin0)-1-(3-pyridyl)-1-butanone from cigarette smoke.
J. Pharmacol. Exp. Therap. 311, 123-130.
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Shin, V.Y., Wu, W.K.K., Ye, Y.N., So, W.H.L., Koo, M.W.L.,
Liu, E.S.L., Luo, J.C. & Cho, C.H. (2004). Nicotine promotes gastric tumor
growth and neovascularization by activating extracellular signal-regulated
kinase and cyclooxygenase-2. Carcinogenesis 25, 2487-2495.
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Luo, J.C., Shin V.Y., Yang, Y.W., Wu, W.K.K., Ye, Y.N., So,
W.H.L., Chang, F.Y. and Cho, C.H. (2005). Tumor necrosis-a stimulates
gastric epithelial cell proliferation. Am. J. Physiol. Gastrointest. Liver
Physiol. 288, G32-G38.
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Ye, Y.N., Wu, W.K.K., Shin, V.Y., Bruce, I.C., Wong, B.C.Y.
& Cho, C.H. (2005). Dual inhibition of 5-LOX and COX-2 suppresses colon
cancer formation promoted by cigarette smoke. Carcinogenesis 26, 827-834.
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Wu, W.K.K., Wong, H.P.S., Luo, S.W., Chan, K., Huang, F.Y.,
Hui, M.K.C., Lam, E.K.Y., Shin, V.Y., Ye, Y.N., Yang, Y.H. & Cho, C.H.
(2005). 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone from cigarette smoke
stimulates colon cancer growth via b-adrencoceptors. Cancer Res. 65,
5272-5277.
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Shin, V.Y., Koo, M.W.L., Wu, W.K.K., Wong, H. P.S., Lam,
E.K.Y., Tai, E. K.K., Chu, K.M. & Cho, C.H. (2005). Nicotine Induces
Cyclooxygenase-2 and Vascular Endothelial Growth Factor Receptor-2 in
Association with Tumor-Associated Invasion and Angiogenesis in Gastric Mol.
Cancer Res. 3, 607-615.
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Wu, W.K.K., Li, G.R., Wong, H.P.S., Hui, M.K.C., Tai,
E.K.K., Lam, E.K.Y., Shin, V.Y., Ye, Y.N., Li, P., Yang, Y.H., Luo, J.C. &
Cho, C.H. (2006). Involvement of Kv1.1
and Nav1.5 in proliferation of gastric epithelial cells. J. Cell.
Physiol. 207, 437-444.
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Yang, Y.H., Wu, W.K.K., Tai, E. K.K., Wong, H. P.S., Lam,
E.K.Y., Shin, V.Y. & Cho, C.H. (2006). The cationic host defense peptide
rCRAMP promotes gastric ulcer healing in rats. J. Pharmacol. Exp. Therap. 318,
547-554.
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Shin, V.Y., Wu, W.K.K., Koo, Chu, K,M., M.W.L, Wong,
H.P.S., Lam, E. K.Y., Tai, E.K.K. & Cho, C.H. (2007). Functional role
of b-adrenergic receptor in the mitogenic action of nicotine on gastric
cancer cells. Tox. Sci. 96, 21-29.
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Wong, H.P.S., Yu, L., Lam, E.K.Y., Tai, E.K.K., Wu, W.K.K.
& Cho, C.H. (2007). Nicotine promotes colon cancer growth
via a7-nicotinic acetylcholine receptor and catecholamine-synthesizing
enzymes-mediated pathway. Tox. Appl. Pharmacol. 221, 261-267.
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Wu, W.K.K., Sung J.J.Y., Yu, L. & Cho, C.H. (2008).
Bone morphogenetic protein signaling is required for the anti-mitogenic effect
of proteasome inhibitor MG-132 on colon cancer cells. Br. J.
Pharmacol.154, 632-638.
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Liu, X., Wu, W.K.K., Sung J.J.Y., Yu, L., Li, Z.J. Zhang
S.T. & Cho, C.H. (2008). Epidermal growth factor stimulates esophageal
cancer cell growth via transactivation of β-adrenoceptor. J. Pharmacol. Exp.
Therap. 326, 69-75.
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Yu, L., Wu, W.K.K., Wong, H.P.S., Tai, E.K.K., Li, Z.J.,
Li, H.T., Wu Y.C. & Cho, C.H. (2008). EP2 receptor-mediated activation of
extracellular signal-regulated kinase/activator protein-1 signaling is required
for the mitogenic action of prostaglandin E2 in esophageal squamous-cell carcinoma. J. Pharmacol. Exp.
Therap. 327: 258-267.
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Yu, L., Wu, W.K.K., Li, Z.J., Liu Q.C., Li, H.T., Wu, Y.C.
& Cho, C.H. (2009). Enhancement of doxorubicin cytotoxicity on human
esophageal squamous cell carcinoma cells by indomethacin and SC236 via
inhibiting P-glycoprotein activity. Mol. Pharmacol. 75, 1364-1373 (accepted,
top ten articles viewed by readers in March 2009).
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Yu, L., Wu, W.K.K., Li, Z.J., Li, H.T., Wu, Y.C. & Cho,
C.H. (2009). Prostaglandin E2 promotes cell prooliferation via
protein kinase C / extracellular signal regulated kinase pathway-dependent
induction of c-Myc expression in human esophageal squamous cell carcinoma
cells. Int. J. Cancer, 125, 2540-2546.
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Wu, W.K.K., Sung, J.J.Y., To, K.F., Yu, L., Chu, K.M., Yu,
J. & Cho, C.H. (2010). The host defense peptide LL-37 activates the
tumor-suppressing bone morphogenetic protein signaling via inhibition of
proteasome in gastric cancer cells. J. Cell. Physiol. 223, 178-186.
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Wu, W.K.K., C.H. Cho (co-correspondence author) , Lee, C.,
Wu, Y.C., Yu, L., Li, Z.J., Wong, C.C.M., Li, H.T., Zhang, L., Ren, S.X., Che,
C.T., Yu, J. & Sung, J.J.Y. (2010). Macroautophagy and ERK phosphorylation
counteract the anti-proliferative effect of proteasome inhibitor in gastric cancer
cells. Autophagy, 6, 1-11.
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Li, Z.J., Wu, W.K.K., Ng, S.S.M., Yu, L., Li, H.T., Wong
C.C.M., Wu, Y. C., Zhang, L., Ren S.X., Sun, X.G., Chan, K.M. & Cho, C.H.
(2010). A novel peptide specifically targeting the vasculature of orthotopic
colorectal cancer for imaging detection and drug delivery. J. Controlled
Release 148, 292-302.
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Yu, L., Chen, M.H., Li, Z.J., Wen J., Fu, S.G., Jiang Y.,
Wu S.G., Cho, C.H. & Liu S.W. (2011). Celecoxib antagonizes the
cytotoxicity of cisplatin in human esophageal squamous cell carcinoma cells by
reducing intracellular cisplatin accumulation. Mol. Pharmacol. 79,
608-617.
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Ren S.X., Cheng, A.S.L., To, K.F., Tong, J. H.M., Li, M.S.,
Wong, C.C.M., Shen, J., Zhang, L., Chan, R.L.Y., Wang, X.J., Ng, S.S.M.,
Chiu, L.C.M., Marquez, V.E., Gallo, R.L., Chan, F.K.L., Yu, J., Sung, J.J.Y.,
Wu, W.K.K. & Cho, C.H. (2012). Host immune defense peptide LL-37
activates caspase-independent apoptosis and suppresses colon colon cancer.
Cancer Research 72, 6512-6523.
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Zhang, L., Wu, W.K.K., Ling, T.K.W., Wong C.C.M., Li, Z.J.,
Chan, K.M., Ren, S.X., Shen J., Chan R.L.Y., Lee, C.C., Li, M.S.M., Cheng,
A.S.L., To, K.F., Gallo, R.L. Yu, J. and Cho, C.H. (2013). Cathelicidinprotects
againstHelicobacter pylori colonization
and the associated gastritis in mice. Gene Therapy 20, 751-760.
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Shen, J., Xiao, Z.G.,, Wang, M.H.,To. K.F., Che, Y.C., Li,
M.S., Tong, J.H., Kang W., Zhang L., Wang , L., Lu, L., Chan,
R.L.Y., Yu, J., Chan, F.K.L., Sung, J.J.Y., Cheng, A.S. & Cho, C.H.
(2015).MiR-490-3p targeting SMARCD1, a member of the SWI/SNF chromatin
remodeling family, was epigenetically silenced in H. pylori-induced gastric
carcinogenesis. Cancer Res. 75, 754-765.
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Lu, L., Li,
Z.J., Li, L.F., Wu, W.K.K., Shen, J., Zhang, L., Chan, R.L.Y., Yu, L., Liu,
Y.W., Ren, S.X., Chan, K.M. & Cho, C.H. (2015). Vascular-targeted TNFα
enhances vascular function and benefitsantitumor
immunotherapy in colorectal cancer. J. Controlled Release 210, 134-146.