Dr. Nicholas R. Forsyth
Institute for Science & Technology in Medicine
Keele University Medical School,UK
Email: n.r.forsyth@pmed.keele.ac.uk
Qualifications
2002 Ph.D., Beatson Institute for Cancer Research, UK
1994 B.Sc., Molecular Biology Upper Second Class, Glasgow University, Glasgow
Publications (Selected)
-
Kay A., Richardson J.B., Forsyth N.R.
Physiological normoxia suppresses dedifferentiation and promotes chondrogenic
potential of human articular chondrocytes. Manuscript accepted. Frontiers in
Bioscience.
-
Khondoker A, Kumar D, Mohan P, Forsyth NR.
Stem cell-based therapy for the older patient. Invited review. Aging Health.
-
Pijanka JK, Kumar D, Yousef I, Parkes G,
Untereiner V, Yang Y, Dumas D, Collins C, Sockalingum GD, Forsyth NR, and
Sulé-Suso J. Vibrational spectroscopy differentiates between multipotent and
pluripotent stem cells. Analyst. In Press
-
Wimpenny I, Hampson K, Yang Y, Ashammakhi
N, Forsyth NR. One step recovery of marrow stromal cells on nanofibers. Tissue
Engineering. 2009 Aug 17. [Epub ahead of print]
-
Forsyth NR*, et al Transcriptome
alterations due to physiological normoxic (2% O2) culture of human embryonic
stem cells. Regenerative Medicine (2008). Nov;3(6):817-33.* indicates
communicating author.
-
Bullough R*, Finnigan T*, Kay A, Maffulli
N, Forsyth NR. Tendon Repair through Stem Cell Intervention: Cellular and
Molecular Approaches. Disability and Rehabilitation. 2008 Jul 5:1-6.* indicates
equal author contribution.
-
Rahman R, Forsyth NR, & Cui W.
Telomeric 3 '-overhang length is associated with the size of telomeres.
Experimental Gerontology. 2008 April; 43 (4): 258-265.
-
Tremoleda JL, Forsyth NR, et al Bone
tissue formation from Human embryonic stem cells in vivo. Cloning and Stem
Cells. 2008 March;10(1): 119-131.
-
Forsyth N. R* and McWhir J. Human
Embryonic Stem Cell Telomere Length Impacts Directly on Clonal Progenitor
Isolation Frequency. Rejuvenation Research. 2008 Feb;11(1): 5-17. * indicates
communicating author.
-
Maida Y, Kyo S, Forsyth NR, et al.
Distinct telomere length regulation in premalignant cervical and endometrial
lesions: implications for the roles of telomeres in uterine carcinogenesis. J
Pathol. 2006 Oct;210(2):214-23.
-
Hewitt Z*, Forsyth NR*, et al
Fluorescence-activated single cell sorting of human embryonic stem cells.
Cloning Stem Cells. 2006 Fall;8(3):225-34. * indicates equal author
contribution.
-
Forsyth N. R*., et al Low oxygen enhances
hESC clonal recovery and reduces chromosomal abnormalities. 2006. Cloning and
Stem Cells 2006;8(1):16-23. * indicates communicating author.
-
Forsyth N. R., et al Lagomorphs do not
exhibit telomere-directed aging in vitro. 2005
Jun-Jul;126(6-7):685-91.Mechanisms of Ageing and Development.
-
Forsyth N. R., et al Spontaneous
Immortalization of Clinically normal Colon-derived fibroblasts from a Familial
Adenomatous Polyposis (FAP) Patient. 2004 May-Jun;6(3):258-65. Neoplasia
-
Walter, M., Forsyth, N. R., et al The
establishment of telomerase-immortalized tangier disease cell lines indicates
the existence of an apolipoprotein A-I-inducible but ABCA1-independent
cholesterol efflux pathway. 2004 May 14;279(20):20866-73.. JBC.
-
16) Forsyth, N. R., et al Developmental
differences in the immortalization of lung fibroblasts by telomerase. Aging
Cell 2 (5): 235-243. 2003
-
Forsyth, N. R., et al Telomerase and
differentiation in multicellular organisms: Turn it off, turn it on, and turn
it off again. Differentiation 69 (4-5), 188-197. 2002
-
Bryce, S. D., Morrison, V., Craig, N. J.,
Forsyth, N. R., et alA Mortality Gene(s) for the Human Adenocarcinoma Line HeLa
Maps to a 130kb Region of Human Chromosome 4q22-q23. Neoplasia 4 (6): 544-550. 2002
-
Forsyth, N. R., et al Functional evidence
for squamous cell carcinoma mortality gene(s) on human chromosome 4. Oncogene
21(33): 5135-47. 2002
-
Parkinson E. K., Munro J., Steeghs K.,
Morrison V., Ireland H., Forsyth N. R., Fitzsimmons S. A., Bryce S.D.
Replicative Senescence as a Barrier to Human Cancer. Biochemical Society
Transactions 28, 226-233, 2000