Dr. Laimute Taraseviciene-Stewart
School of Medicine
University of Colorado, Denver, USA
Assistant Professor
Email: Laima.Taraseviciene@ucdenver.edu
Qualifications
1993 Ph.D., Institute of Biochemistry, Lithuanian Academy of Sciences, Lithuania
1977 Ph.D., Institute of Molecular Biology and Genetics, Ukrainian Academy of Sciences, Kiev, Ukraine
1971 M.S., Vilnius University, Lithuania
Publications (selected)
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K-H. Choe,L.
Taraseviciene-Stewart,R. Scerbavicius, L. Gera, R.M.
Tuder, N.F. Voelkel.Methylprednisolone Causes Matrix Metalloproteinase-dependent
Emphysema in Adult Rat. Amer. J. Resp. Crit. Care Med. 167(11):1516-21, 2003
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R.M. Tuder, L. Zhen, C.Y. Cho,L. Taraseviciene-Stewart, Y. Kasahara, D. Salvemini,
N.F. Voelkel, S. Flores. Oxidative Stress and Apoptosis Interact and Cause
Emphysema Due to VEGF Receptor Blockade: Prevention of emphysema with a
superoxide dismutase mimetic. Am J Resp Cell Mol Biol 29(1):88-97, 2003
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Norbert F. Voelkel,Laima
Taraseviciene-Stewart,Rubin Tuder. Emphysema – a vascular disease? Drug Discovery
Today: Disease Mechanisms, 1(1):145-149, October, 2004
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Golpon HA, Fadok VA, Taraseviciene-Stewart L, Scerbavicius
R, Henson PM, Voelkel NF. Life After Corpse Engulfment. FASEB J, 2004
Nov;18(14):1716-8.
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Y. Demura,L.
Taraseviciene-Stewart,R. Scerbavicius, R.M. Tuder, N.F. Voelkel.
N-acetylcysteine Treatment Protects Against VEGF-Receptor Blockade-Related
Emphysema. COPD, 1(1):25-32, 2004
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J.M. Stewart, L. Gera, D.C. Chan, E.J. York,L. Taraseviciene-Stewart,
V. Simkeviciene, B. Helfrich. New Lung Cancer Drugs from Bradykinin
Antagonists. CHEST 2004; 125:148S
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Norbert F. Voelkel,Laima
Taraseviciene-Stewart. Emphysema – an Autoimmune Vascular Disease.
Proc. Am. Thor. Soc. Apr 2005;2: 23 - 25.
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Taraseviciene-Stewart L, Scerbavicius R, Choe KH, Moore M,
Sullivan A, Nicolls MR, Fontenot AP, Tuder RM, Voelkel NF. An Animal Model
of Autoimmune Emphysema. Am J Respir Crit Care Med. 2005 Apr 1;171(7):734-42.
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John M. Stewart, Lajos Gera, Daniel C. Chan, Eunice J. York,
Vitalija Simkeviciene, Paul Bunn Jr.,Laimute
Taraseviciene-Stewart. Combination Cancer Chemotherapy with one
compound: Pluripotent Bradykinin Antagonist. Peptides, 2005 Aug; 26(8):1288-91.
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Laimute Taraseviciene-Stewart,Robertas Scerbavicius, John M. Stewart, Lajos Gera, Yoshiki
Demura, Carlyne Cool, Michael Kasper and Norbert F. Voelkel. Treatment of
Severe Pulmonary Hypertension: a bradykinin receptor 2 agonist B9972
causes reduction of pulmonary artery pressure and right ventricular
hypertrophy. Peptides, 2005 Aug; 26(8):1292-300.
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Sakao S,Taraseviciene-Stewart
L, Lee JD, Wood K, Cool CD, Voelkel NF. Initial apoptosis is
followed by increased proliferation of apoptosis-resistant endothelial
cells. FASEB J. 2005 Jul;19(9):1178-80.
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Mark R. Nicolls,Laima
Taraseviciene-Stewart,Pradeep R. Rai, David B. Badesch,
Norbert F. Voelkel. Autoimmunity and Pulmonary Hypertension:A
Perspective,Eur. Resp. J. 2005 Dec;26(6):1110-8.
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Irina Petrache, Iwona Fijalkowska, Lijie Zhen, Terry R.
Medler, Jarrett Skirball, Terrence Flotte, Kang- Hyeon Choe,Laimute Taraseviciene-Stewart,
Robertas Scerbavicius, Lee Shapiro, Norbert Voelkel, Rubin Tuder. A novel
antiapoptotic role for alpha 1 antitrypsin in the prevention of emphysema.
Am J Respir Crit Care Med. 2006 Jun 1; 173(11):1222-1228.
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Achcar,R.O., Demura,Y., Rai,P.R.,Taraseviciene-Stewart,L.,Kasper,M., Voelkel,N.F. and
Cool,C.D. Loss of caveolin and heme oxygenase expression in severe
pulmonary hypertension, Chest,129:696- 05, 2006.
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Sakao, S.,Taraseviciene-Stewart,
L., Wood, K., Cool, C. D., and Voelkel, N. F. Apoptosis of
Pulmonary Microvascular Endothelial Cells Stimulates Vascular Smooth
Muscle Cell Growth. Am.J Physiol Lung Cell Mol.Physiol 2006;291(3):L362-L368.
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Taraseviciene-Stewart, L.,Burns, N., Kraskauskas, D., Nicolls,
M. R., Tuder, R. M., and Voelkel, N. F. Mechanisms of Autoimmune
Emphysema. Proc.Am.Thorac.Soc. 2006;3(6):486-7.
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Taraseviciene-Stewart, L.,Scerbavicius, R., Choe, K. H., Cool,
C., Wood, K., Tuder, R. M., Burns, N., Kasper, M., and Voelkel, N. F.
Simvastatin Causes Endothelial Cell Apoptosis and Attenuates Severe
Pulmonary Hypertension. Am.J Physiol Lung Cell Mol.Physiol
2006;291(4):L668-L676.
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Taraseviciene-Stewart L, Douglas IS, Nana-Sinkam PS, Lee JD,
Tuder RM, Nicolls MR, Voelkel NF. Is alveolar destruction and emphysema in
chronic obstructive pulmonary disease an immune disease? Proc Am Thorac
Soc. 2006 Nov;3(8):687-90
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Masahiko Oka, Noriyuki Homma,Laimute Taraseviciene-Stewart, Kenneth G. Morris,
DonatasKraskauskas, Nana Burns, Norbert F. Voelkel, Ivan F. McMurtry.
Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary
arterial hypertension in rats. Circ Res. 2007 Mar 30;100(6):923-9.
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Laimute Taraseviciene-Stewart, Mark R. Nicolls, Donatas Kraskauskas,
Robertas Scerbavicius, Nana Burns, Carlyne Cool, Kathy Wood, Jane E. Parr,
Susan Boackle and Norbert F. Voelkel. Absence of T Cells Confers an
Increased Pulmonary Arterial Hypertension and Vascular Remodeling. Am J
RespirCrit Care Med. 2007 Jun 15; 175(12): 1280-9.
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Sakao S,Taraseviciene-Stewart
L, Cool CD, Tada Y, Kasahara Y, Kurosu K, Tanabe N, Takiguchi Y,
Tatsumi K, Kuriyama T, Voelkel NF. VEGF-R blockade causes endothelial cell
apoptosis, expansion of surviving CD34+ precursor cells and
transdifferentiation to smooth muscle-like and neuronal-like cells. FASEB
J. 2007 Nov; 21(13):3640-52.
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Daley E, Emson C, Guignabert C, de Waal Malefyt R, Louten J,
Kurup VP, Hogaboam C,Taraseviciene-Stewart
L, NF, Voelkel NF, Rabinovitch M, Grunig E,
Grunig G. Pulmonary arterial remodeling induced by a Th2 immune response. J Exp
Med. Vol. 205, No. 2, 361-372, 2008
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Taraseviciene-Stewart, L. and Voelkel, N. F. Molecular
Pathogenesis of Emphysema. JCI, 2008; 118(2):354-402.
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Silvia Ulrich, Mark R. Nicolls,Laima Taraseviciene, Rudolf Speich, Norbert Voelkel.
IncreasedRegulatory and Decreased CD8+ Cytotoxic T Cells in the Blood of
Patients with Idiopathic Pulmonary Arterial Hypertension.Respiration2008;75:272-280
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Silvia Ulrich,Laima
Taraseviciene-Stewart, Lars C Huber, Rudolf Speich and Norbert
VoelkelPeripheral blood B lymphocytes derived from patients with
idiopathic pulmonary arterial hypertension express a different RNA pattern
compared with healthy controls: a cross sectional study.Respiratory
Research2008, 9:20
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Homma N, Nagaoka T, Karoor V, Imamura M,Taraseviciene-Stewart L,
Walker LA, Fagan KA,McMurtry IF, Oka M., Involvement of RhoA/Rho kinase signaling indehydroepiandrosterone'sprotection against monocrotaline-induced pulmonary hypertension
in pneumonectomized rats.Am J Physiol Lung Cell Mol Physiol.2008
Jul;295(1):L71-8.
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Woodward,H.N., Anwar,A., Riddle,S.,Taraseviciene-Stewart,L., Fragoso,M., Stenmark,K.R.,
and Gerasimovskaya,E.V., PI3K, Rho and ROCK play a key role in
hypoxia-induced ATP release and ATPstimulated angiogenic responses in
pulmonary artery vasa vasorum endothelial cells.Am.J Physiol Lung Cell
Mol.Physiol, 2009 Nov;297(5):L954-64.
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Masayuki Hanaoka, Mark R. Nicolls, Andrew P. Fontenot,
Donatas Kraskauskas, Douglas G.Mack, Adelheid Kratzer, Vita Kraskauskiene,
Nana Burns, Norbert F. Voelkel, andLaimuteTaraseviciene-Stewart.Immunomodulatory Strategies Prevent the Development of Autoimmune
Emphysema.Respiratory Research2010, 11:179
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Kearns
MT, Dalal S, Horstmann SA, Richens TR, Tanaka T, Doe JM, Boe DM, Voelkel
NF,Taraseviciene-StewartL,
Janssen WJ, Lee CG, Elias JA, Bratton D, Tuder RM, Henson PM, Vandivier RW.Vascular endothelial growth factor
enhances macrophage clearance of apoptotic cells.Am J Physiol
Lung Cell Mol Physiol. 2012 Apr;302(7):L711-8.
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Gerasimovskaya E, Kratzer A, Sidiakova A,
Salys J, Zamora M,Taraseviciene-StewartL.Interplay of macrophages and T
cells in the lung vasculature.Am
J Physiol Lung Cell Mol Physiol.2012 Apr
1;302(7):L711-8.
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